Todd Fraser, MD, speaks with Daniel F. McAuley, MD, about his article, “Simvastatin in the Acute Respiratory Distress Syndrome,” published in the October 2014 New England Journal of Medicine. McAuley and the Irish Critical Care Trials Group tested the hypothesis that treatment with simvastatin would improve clinical outcomes in patients with acute respiratory distress syndrome (ARDS). Studies in animals and in vitro and phase 2 studies in humans suggest that statins may be beneficial in the treatment of this condition.