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Better understanding of important aspects of trial design and interpretation, such as whether patients enrolled in both intervention arms were comparable and whether the primary outcome of the trial is clinically important, will assist the bedside clinician in determining whether to apply the findings from the clinical study into clinical practice. Jonathan E. Sevransky, MD, MHS, discusses his September 2010 Critical Care Medicine article on this topic, titled “Critical Care Trial Design and Interpretation: A Primer.” Sevransky is an assistant professor of medicine at Johns Hopkins Bayview Medical Center in Baltimore, Maryland.
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