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The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness

From Critical Care Explorations. This article describes the conception and implementation of an intensive care database rapidly developed and designed to meet data analytic needs in response to the coronavirus disease 2019 pandemic - the multicenter, international Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study.


The Clinical Presentation and Immunology of Viral Pneumonia and Implications for Management of Coronavirus Disease 2019

From Critical Care Explorations. This article examines the clinical presentation and important immunology of viral pneumonia with a focus on severe acute respiratory syndrome coronavirus 2 (coronavirus disease 2019).


Misinformation During the Coronavirus Disease 2019 Outbreak: How Knowledge Emerges From Noise

From Critical Care Explorations. This review summaries the many potential sources of information that clinicians turn to during pandemic illness, the challenges associated with performing methodologically sound research in this setting and potential approaching to conducting well done research during a health crisis.


Caring for Critically Ill Adults With Coronavirus Disease 2019 in a PICU: Recommendations by Dual Trained Intensivists

From Pediatric Critical Care Medicine. Although pediatric intensivists are well versed in the care of ARDS from viral pneumonia, the care of an differing aged adult populations presents some unique challenges.


Caring for Critically Ill Adults in PICUs Is Not "Child's Play"

From Pediatric Critical Care Medicine. Editorial by authors that led the Pediatric Emergency Mass Critical Care Task Force and 2014 Task Force for Mass Critical Care.


Coronavirus Disease 2019 in Children: An Invisible Threat Which We Cannot Ignore

From Pediatric Critical Care Medicine. Editorial in response to Ong et al. article ("A comprehensive narrative review on the impact and implications of COVID-19 in children"), focusing on the management of those most severely affected, as well as providing some practical suggestions for pediatric intensive care clinicians to prepare should COVID-19 become more virulent in children.


Time Course of Evolving Ventilator-Induced Lung Injury: The "Shrinking Baby Lung"

From Critical Care Medicine. This paper introduces and highlights several important and /or novel concepts seldom considered by the practicing intensivist.


Editorial: Dealing With the CARDS of COVID-19

From Critical Care Medicine. An editorial associated with the Mauri et al. article on personalized ventilation for COVID-19 ARDS patients.


Proposal for Coronavirus Disease 2019 Management

From Critical Care Explorations. During a pandemic, with limited resources, we should provide the safest and most effective care, while protecting caregivers.The authors propose ways to do that.


Frequency of Continuous Renal Replacement Therapy Use Early in Coronavirus Disease 2019 Pandemic

From Critical Care Explorations. The authors reviewed the available literature to understand the frequency of continuous renal replacement therapy use among patients with coronavirus disease 2019 who required intensive care.


Extracorporeal Membrane Oxygenation for Pediatric Patients With Coronavirus Disease 2019–Related Illness

From Pediatric Critical Care Medicine. The authors describe current hospital guidelines and the opinions of extracorporeal membrane oxygenation leaders at U.S. children’s hospitals concerning the use of extracorporeal membrane oxygenation for coronavirus disease 2019–positive pediatric patients.


Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome: A Multicenter Descriptive Study

From Critical Care Medicine. This study aims to summarize the clinical features, ECMO characteristics, and outcomes of patients with SARS-CoV-2 pneumonia receiving ECMO. The authors conclude ECMO might be an effective salvage treatment for patients with SARS27 CoV-2 pneumonia associated with severe ARDS. Severe CO2 retention and acidosis 28 prior to ECMO indicated a poor prognosis.


Letter to the Editor: The Role of the Pediatric Intensivist in the Coronavirus Disease 2019 Pandemic

From Pediatric Intensive Care Medicine. In this letter to the editor, the authors explore the role of pediatric intensivists, as highly-skilled professionals, in the care of critically ill adults. With adequate guidance by professional societies and adult intensivists, pediatric critical care physicians can provide valuable assistance in the current pandemic and in potential COVID-19 epidemic waves to come.


ICU and Ventilator Mortality Among Critically Ill Adults With Coronavirus Disease 2019

From Critical Care Medicine. To help address the growing concern that critical illness, and specifically mechanical ventilation, are associated with a high risk of death, the authors conducted a retrospective cohort study of critically ill patients with COVID-19 across their academic health system.


Implications of Obesity for the Management of Severe Coronavirus Disease 2019 Pneumonia

From Critical Care Medicine. The authors report on their experience from their first 44 cases of 95 COVID-19 critically ill patients and analyze the link between obesity and this new form of 96 ARDS caused by the SARS-CoV-2 with its potential implications for patients' management.


Just-in-Time Simulation to Guide Workflow Design for Coronavirus Disease 2019 Difficult Airway Management

From Pediatric Critical Care Medicine. Integration of table-top planning, in situ simulations, and debriefing of real COVID19 cases can enhance planning, training, job aids, and feasible policies/procedures that address human factors, team communication, equipment choice, and patient/provider safety in the COVID19 pandemic era.


Less Can Be More When Targeting Interleukin-6-Mediated Cytokine Release Syndrome in Coronavirus Disease 2019

Cytokine release syndrome (CRS) mediated by IL-6 is a critical driver of COVID-19 mortality. The authors review and discuss key immunologic effects of direct IL-6 blockade, downstream non-selective JAK inhibition, and selective JAK2 suppression to treat COVID-19-related CRS.


Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China

From Critical Care Medicine. Mechanical ventilation (MV) is life-saving for respiratory distress; this study was designed to delineate the clinical features of the COVID-19 patients with MV from a national cohort in China.


Design for Implementation of a System-Level ICU Pandemic Surge Staffing Plan

From Critical Care Explorations. The authors provide a description of the design, dissemination, and implementation of an ICU surge provider staffing algorithm, focusing on physicians, advanced practice providers, and certified registered nurse anesthetists, at a system-wide level.


Adult Extracorporeal Membrane Oxygenation Patient Selection During Coronavirus Disease 2019: The Value of a Review Panel During Coronavirus Disease 2019

From Critical Care Medicine. Authors write regarding article by Bohman et al "Approach to Adult Extracorporeal Membrane Oxygenation Patient Selection" and note that a formal approach to decision making is key for the appropriate use of this labori ntensive rescue therapy.