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Respiratory Physiology of Prone Positioning With and Without Inhaled Nitric Oxide Across the Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Severity Spectrum

From Critical Care Explorations. In this observational study, the authors found that prone positioning improves oxygenation across the acute positive respiratory distress syndrome severity spectrum, irrespective of supine respiratory system compliance, end-expiratory pressure, or body mass index. There was a greater relative benefit among patients with more severe disease. Prone positioning confers an additive benefit in oxygenation among patients treated with inhaled nitric oxide.


Early Intubation and Increased Coronavirus Disease 2019 Mortality: A Propensity Score–Matched Retrospective Cohort Study

From Critical Care Explorations. In this observational study, the authors found that iwithin 48 hours of triage, as well as at any time point in the hospital course, was associated with increased mortality in coronavirus disease 2019 patients.


Editorial: Prone Positioning in Coronavirus Disease 2019: Just Do It!

From Critical Care Medicine. This Editorial accompanies the article by Mathews et al. entitled “STOP-COVID Investigators. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019–Related Respiratory Failure.”


Tracheostomy for Coronavirus Disease 2019 Patients on Mechanical Ventilation Should Not Be Arbitrarily Delayed

From Critical Care Medicine. This Editorial accompanies an article by Angel et al. entitled “Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation.”


Online Letter to the Editor: Higher Than Expected Severity-Adjusted Mortality in ICU Patients With Coronavirus Disease 2019: Time to Consider the Contributions of Pandemic-Related Transformations in Structure and Process

From Critical Care Medicine. In this Online Letter to the Editor, the author responds to the article by Higgins et al. entitled “Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation-Adjusted Mortality and Length of Stay Than Viral Pneumonia ICU Patients.”


Letter to the Editor: Lung Abscess in Critically Ill Coronavirus Disease 2019 Patients With Ventilator-Associated Pneumonia: A French Monocenter Retrospective Study

From Critical Care Explorations. In this Letter to the Editor, the authors report that 17 of 119 coronavirus disease 2019 patients (14%) with ventilator-associated pneumonia developed a lung abscess.


Soluble Suppression of Tumorigenicity-2 Associates With Ventilator Dependence in Coronavirus Disease 2019 Respiratory Failure

From Critical Care Explorations. In this study, the authors hypothesized that elevated soluble suppression of tumorigenicity-2 concentrations, a marker of pulmonary epithelial injury, reflects ongoing lung injury in acute hypoxemic respiratory failure due to coronavirus disease 2019 and associate with continued ventilator dependence.


Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

From Critical Care Medicine  In this article, the authors assessed whether right ventricular dilation or systolic impairment is associated with mortality and/or disease severity in invasively ventilated patients with coronavirus disease 2019 acute respiratory distress syndrome.


Performance Analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial Cohort

From Critical Care Explorations.  In this study, the authors sought to validate prognostic scores in coronavirus disease 2019 including National Early Warning Score, Modified Early Warning Score, and age-based modifications, and define their performance characteristics.


Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report

From Critical Care Explorations. Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case ReportG966


Editorial: Bursting at the Seams: Barotrauma in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients

From Critical Care Medicine. This Editorial accompanies an article by Belletti et al. entitled “Barotrauma in Coronavirus Disease 2019 Patients Undergoing Invasive Mechanical Ventilation: A Systematic Literature Review.”


Online Letter to the Editor: The Intriguing, Still Undercovered, Clinical Role of Echocardiography in Critically Ill Coronavirus Disease Patients

From Critical Care Medicine. This Online Letter to the Editor was written in response to an article by  Chotalia et al. entitled “Right ventricular dysfunction and its association with mortality in coronavirus disease 2019 acute respiratory distress syndrome.”


Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry

From Critical Care Explorations. In this study, the authors found that, among hospitalized young adults, obese males with comorbidities are at higher risk of developing critical illness or dying from coronavirus disease 2019.


Adherence to Lung Protective Ventilation in Patients With Coronavirus Disease 2019

From Critical Care Explorations. In this Brief Report, the authors sought to test the hypothesis that patients with acute respiratory distress syndrome due to coronavirus disease 2019, in whom acute respiratory distress syndrome is easily recognized, would be more likely to receive low tidal volume ventilation than concurrently admitted acute respiratory distress syndrome patients without coronavirus disease 2019.  


Psychologic Distress and Quality of Life After ICU Treatment for Coronavirus Disease 2019: A Multicenter, Observational Cohort Study

From Critical Care Explorations. In this study, the authors found that psychologic distress was common in coronavirus disease 2019 ICU survivors and remained similar until 6 months after hospital discharge.


Plasma Exchange in Patients With Severe Coronavirus Disease 2019: A Single-Center Experience

From Critical Care Explorations. The data in this study provide further evidence for plasma exchange as a novel therapeutic strategy in a subset of critically ill coronavirus disease 2019 patients by potentially reversing the complex coronavirus disease 2019 immunopathology.


Bronchoscopy During Coronavirus Disease 2019 Pandemic: A Bronchoscopist’s Perspective

From Critical Care Explorations. In this Commentary, that authors discuss bronchoscopy in patients with coronavirus disease 2019 and conclude that bronchoscopy should be strongly considered when clinically indicated.


Comparison of Published Guidelines for the Diagnosis and the Management of Vaccine-Induced Immune Thrombotic Thrombocytopenia

From Critical Care Explorations. In this Narrative Review, the authors conclude that clinicians should be prepared for the early identification of patients with suspicious symptoms and prompt treatment should be initiated to avoid catastrophic deterioration. They note that major societal guidelines provide useful recommendations for the diagnosis and management of patients with vaccine-induced immune thrombotic thrombocytopenia.


Online Letter to the Editor: Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Do Not Focus on Not Reliable Markers

From Critical Care Medicine. This is an Online Letter to the Editor written in response to Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome by Chotalia et al.


Effectiveness of High-Flow Nasal Cannula in Coronavirus Disease 2019 Pneumonia: A Retrospective Cohort Study

From Critical Care Medicine. In this Clinical Observation, the authors aimed to assess time to discharge and time to death in severe coronavirus disease 2019 in patients treated with high-flow nasal cannula compared with matched controls.