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Category: Research

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Concise Critical Appraisal: The Effect of Ramelteon Administration on the Duration of ICU Stay

Nishikimi et al (Crit Care Med. 2018;46:1099-1105) set out to identify the effects of ramelteon, a melatonin agonist, on ICU length of stay for critically ill patients.

Concise Critical Appraisal: Effect of Sodium Bicarbonate Infusion on Patient Outcomes

Jaber et al (Lancet. 2018;392:31-40) set out to evaluate the effect of sodium bicarbonate infusion on critically ill patient outcomes.

SCCM Pod-388 Choosing Wisely in Critical Care

Ranjit Deshpande, MD, and Ruth M. Kleinpell, PhD, RN, ACNP, FCCM, discuss the results of the Choosing Wisely national survey from the Critical Care Societies Collaborative (Kleinpell R, et al. Crit Care Med. 2019;47:331-336).

They review the Choosing Wisely recommendations and the implementation and impact on ICUs.

Dr. Kleinpell is assistant dean for clinical scholarship at the Vanderbilt University School of Nursing in Nashville, Tennessee, USA.

SCCM Pod-338 Building Global Collaboration in Acute Care Research

Ludwig Lin, MD, speaks with John C. Marshall, MD, FRCSC, FACS, about his talk given at the 46th Critical Care Congress in Honolulu, Hawaii on, “Building Global Collaboration in Acute Care Research.” Dr. Marshall discusses the challenges, needs and opportunities for global research and data sharing. Dr. Marshall is Professor of Surgery at Saint Michael's Hospital in Toronto, Canada. He has no relevant disclosures.

SCCM Pod-203 PCCM: Using the Vanguard Phase in Clinical Trials

Margaret Parker, MD, FCCM, speaks with Victoria L. Pemberton, RN, MS, about her article published in the January Pediatric Critical Care Medicine titled, "Therapeutic Hypothermia After Pediatric Cardiac Arrest Trials: The Vanguard Phase Experience and Implications for Other Trials." The use of an 18-month vanguard phase in the Therapeutic Hypothermia After Cardiac Arrest Trials was beneficial to both investigators and the funding agency, allowing time to refine the protocol for feasibility and safety as well as time to complete administrative activities. Pemberton is a clinical trials specialist at The National Heart, Lung, and Blood Institute in Bethesda, Maryland.

SCCM Pod-179 CCM: Critical Care Research: Its Funding and Future

Jeffrey Guy, MD, MSc, MMHC, speaks with Clifford S. Deutschman, MD, FCCM, and Craig M. Coopersmith, MD, FCCM, who each served as lead authors in two Critical Care Medicine papers related to critical care research. Coopersmith’s paper, “A Comparison of Critical Care Research Funding and the Financial Burden of Critical Illness in the United States,” brings attention to the comparatively low percentage of federal research dollars dedicated to critical care. Months earlier, Dr. Deutschman, in collaboration with members of the Critical Care Societies Collaborative, published a critical care research agenda highlighting key issues and recommendations. Deutschman is the current SCCM president and professor of anesthesiology and critical care at the Perelman School of Medicine at the University of Pennsylvania in Philadelphia. Coopersmith is the SCCM secretary and associate director of the Emory Center for Critical Care in Atlanta, Georgia.

SCCM Pod-138 CCM: Understanding Critical Care Trial Design

Better understanding of important aspects of trial design and interpretation, such as whether patients enrolled in both intervention arms were comparable and whether the primary outcome of the trial is clinically important, will assist the bedside clinician in determining whether to apply the findings from the clinical study into clinical practice. Jonathan E. Sevransky, MD, MHS, discusses his September 2010 Critical Care Medicine article on this topic, titled “Critical Care Trial Design and Interpretation: A Primer.” Sevransky is an assistant professor of medicine at Johns Hopkins Bayview Medical Center in Baltimore, Maryland.

SCCM Pod-98 Congress Preview: Angus Discusses Critical Care Research

Derek C. Angus, MD, MPH, FCCM, the recipient of the American College of Critical Care Medicine's (ACCM) Distinguished Investigator Award, discusses the state of critical care research as well as his unique background. Dr. Angus will accept the award during the 38th Critical Care Congress, where he also will be giving a presentation titled, "Change," during the ACCM Convocation and Award Ceremony. Angus is a professor of critical care at the University of Pittsburgh in Pennsylvania where he is currently chairman of the department of critical care.

Journal Club: Critical Care Medicine

Explore articles from the Society's leading critical care journals in this webcast series.  


Clinicians and data scientists collaborate to address real-world critical care issues and improve patient care. 

Concise Critical Appraisal: Cerebral Oxygen Metabolism and RBC Transfusion in Infants

Neunhoeffer et al (Pediatr Crit Care Med. 2018;19:318-327) sought to use noninvasive means to determine the changes in cerebral oxygen metabolism in infants younger than 6 months who have undergone major surgery.  

Concise Critical Appraisal: Fluid Administration and Diabetic Ketoacidosis

Kuppermann et al (N Engl J Med. 2018;378:2275-2287) sought to prospectively determine the role that fluid makeup and rate have on the development of neurologic injury in children with DKA.

Help Shape the Future of Sepsis Research on the National Level

The National Institute of General Medical Sciences (NIGMS) is changing its priorities to invest in sepsis research in a more targeted and strategic way. In an important opportunity to help shape the future of sepsis research, NIGMS has issued a request for information related to its new priorities. The request for information is found here and is due by November 15, 2019.

SCCM Pod-420 Nebulized Bacteriophages for Prophylaxis of Experimental MRSA VAP

Alternative strategies are needed to combat and prevent antibiotic-resistant bacterial infections. Host Ashish K. Khanna, MD, FCCP, FCCM, talks with David R. Cameron, PhD, about the potential for bacteriophage prophylaxis in the context of experimental ventilator-associated pneumonia due to methicillin-resistant Staphylococcus aureus in rats (Prazak J, et al. Crit Care Med. 2020;48:1042-1046). Dr. Cameron is research group leader in the department of intensive care medicine at Inselspital, Bern University Hospital in Bern, Switzerland.

SCCM Pod-413 COVID-19 Fact Versus Science Fiction

Explore the need for randomized COVID-19 clinical trials and the difficulties and potential consequences of misinformation (Ingraham N, et al. Crit Care Explor. 2020;2:e0108) with host Ashish K. Khanna, MD, FCCP, FCCM, and Nicholas E. Ingraham, MD.

Dr. Ingraham is a fellow and a part of the University of Minnesota's Department of Medicine in the Division of Pulmonary and Critical Care in Minneapolis, Minnesota, USA.

SCCM Pod-390 Telehealth and Patient Outcomes

Ranjit Deshpande, MD, and Donna Lee Armaignac, PhD, APRN, CCNS, CCRN, discuss maximizing positive patient care outcomes through telemedicine.

Dr. Armaignac presented on this topic at the Society's 48th Critical Care Congress.

Dr. Armaignac is the director of best practice for telehealth/tele-ICU and director of the Center for Advanced Analytics at Baptist Health South Florida in Coral Gables, Florida, USA.

SCCM Pod-377 Procalcitonin Guidance in Patients with Sepsis

Ludwig H. Lin, MD, and Philipp Schuetz, MD, discuss procalcitonin and how it impacts treatment of sepsis. This podcast originated from the article "Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis" (Iankova I, et al. Crit Care Med. 2018;46:691-698).

Dr. Schuetz is a professor of internal medicine, endocrinology, diabetes, and metabolism at the University of Basel in Basel, Switzerland.

This podcast is sponsored by Thermo Fisher Scientific.

SCCM Pod-354 The Septic Shock 3.0 Definition and Trials

Ranjit Deshpande, MD, speaks with James A. Russell, MD, about the article, “The Septic Shock 3.0 Definition and Trials: A Vasopressin and Septic Shock Trial Experience,” published in the June 2017 issue of Critical Care Medicine. Dr. Russell discusses findings from his retrospective analysis of the Vasopressin and Septic Shock Trial (VASST) using the Septic Shock 3.0 definition, and implications for trial design in septic shock. Dr. Russell is a professor of medicine at the University of British Columbia, and principal investigator at the Centre for Heart Lung Innovation at St. Paul’s Hospital in Vancouver, BC, Canada. Crit Care Med. 2017; 45(6):940-948. Released: 11/16/17

SCCM Pod-347 High-Quality Randomized Controlled Trials in Pediatric Critical Care

Margaret Parker, MD, MCCM, speaks Mark Duffett, PhD, about the article, “High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators," published in the May 2017 issue of Pediatric Critical Care Medicine. In this article, Dr. Duffett and coauthors identify barriers and facilitators of conducting high-quality randomized controlled trials in pediatric critical care from the perspective of trialists in the field. Dr. Duffett is a Pharmacist in the Department of Pediatrics at McMaster University in Ontario, Canada. Pediatr Crit Care Med. 2017; 18(5):405-413. Released: 8/17/17

SCCM Pod-334 Vasopressors: Future Research

Margaret Parker, MD, MCCM, speaks with Lakhmir S. Chawla, MD, about future research related to the Congress session “Bench-Pressing in the ICU: Which Vasopressor Agent Should I Choose for My Patient?” which he presented at the 45th Critical Care Congress in Orlando, Florida. Dr. Chawla is an Intensivist and Nephrologist and is Professor of Anesthesiology and Critical Care Medicine at George Washington University in Washington, D.C.