SCCM is performing maintenance on its websites. For the best browsing experience, please use Microsoft Edge or Safari. Those using Chrome or Firefox may experience access issues at this time.

Category: Pharmacology

Category Search

visual bubble
visual bubble
visual bubble
visual bubble

Current Approved Therapies for COVID-19

Stay up to date on the mass vaccination efforts in the United States with this SCCM webcast. Thought leaders will address current COVID-19 variants and vaccine efficacy and review pediatric vaccination considerations. This webcast is the second in a series of updates that SCCM is producing to better educate clinicians as vaccination efforts continue. The webinar was held on December 8, 2021.


Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group

From Critical Care Explorations. In this study the authors found that hospital variation in the use of repurposed medications varied widely across hospitals early in the pandemic and later converged with the emergence of randomized clinical trials. 


Concise Critical Appraisal: Vasopressin and Methylprednisolone for In-Hospital Cardiac Arrest

Although several trials have examined in-hospital cardiac arrest (IHCA), only two trials in the past decade have examined the use of vasopressin and glucocorticoids for IHCA. Both trials found improved survival and favorable neurologic outcome with a vasopressin-epinephrine-methylprednisolone combination. Because of a lack of additional supporting evidence, neither the American nor European international guidelines have recommended this combination for IHCA. This Concise Critical Appraisal examines an article by Andersen et al that attempted to validate the results of these trials.
 


Concise Critical Appraisal: Hydrocortisone and Fludrocortisone Versus Hydrocortisone Only

Is hydrocortisone for septic shock best used alone or in combination with fludrocortisone? This Concise Critical Appraisal explores a retrospective cohort study that found that treatment with hydrocortisone plus fludrocortisone led to lower rates of mortality or discharge to hospice, hospital deaths, and fewer days on vasopressors than treatment with hydrocortisone alone.


Tocilizumab May Reduce Mortality in Certain COVID-19 Patients

Two recent trials suggest that immune-damping drugs such as tocilizumab may reduce mortality in patients with severe COVID-19.


SCCM Pod-468: When Should Antibiotics Be Used to Treat Respiratory Infections?

Although only a small number of patients hospitalized with COVID-19 present with a secondary bacterial pneumonia, a large percentage are unnecessarily treated with antibiotics. Pamela M. Peeke, MD, MPH, FACP, FACSM, is joined by George Sakoulas, MD, to discuss how physicians and hospitalists can identify when antibiotics are unnecessary for hospitalized patients with moderate to severe respiratory infections. Dr. Sakoulas is chief of infectious disease at Sharp Rees-Stealy Medical Group in San Diego, California, and an adjunct professor in the Division of Host-Microbe Systems and Therapeutics Center for Immunity, Infection, and Inflammation at the University of California San Diego School of Medicine in La Jolla, California. This podcast is sponsored by bioMérieux.


Safe Medication Use in the ICU

Crit Care Med 2017; 45(9):e877-e915


Push-Dose Vasopressor Safety and Efficacy

Are push-dose vasopressors (PDPs) safe and effective for patients with hypotension outside the operating room? This Concise Critical Appraisal covers a recent study that sought to determine whether phenylephrine and epinephrine are effective for acute hypotensive periods when PDP protocols are in place.


Surviving Sepsis Campaign COVID-19 Guidelines: Therapy Recommendation Chart

COVID-19 - - Quick Reference Chart. This chart is to be used as a rapid resource when choosing therapeutic options for treating COVID-19 patients.


Timing of Antibiotics in Septic Patients With Septic Arthritis

When should antibiotics be administered in septic patients with septic arthritis? This Concise Critical Appraisal reviews a recent study that sought to determine whether patients with septic arthritis should receive antibiotics prior to synovial fluid aspiration analysis or wait until synovial fluid analysis has been completed.


REDISCOVER-ICU: Utilizing Data to Study Drug Repurposing Beyond COVID-19

The COVID-19 pandemic exposed significant gaps in the healthcare system, such as healthcare inequities and the need for more treatment options for intensive care unit patients with serious illnesses. Looking beyond COVID-19 to sepsis and other critical care illnesses, the Society of Critical Care Medicine and Critical Path Institute’s CURE Drug Repurposing Collaboratory are collaborating on the new study Repurposing Drugs in Intensive Care Units Through Real-World Data Analysis (REDISCOVER-ICU).


Surviving Sepsis Campaign: Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19)

Webcast participants were able to learn more about the recommendations included in the guidelines regarding infection control, laboratory diagnosis and specimens, hemodynamic support, ventilatory support


What is the role of antibody testing, and what is the PCR turnaround time, and the sensitivity and specificity?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered.


What are your thoughts about using glucocorticoids in patients with severe ARDS secondary to COVID-19 who remain intubated after 7 days?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered.


Surviving Sepsis Campaign COVID-19 Guidelines (Chinese Translation)

COVID-19 Guideline Resource. SCCM has released its Surviving Sepsis Campaign COVID-19 guidelines to manage critically ill adults with COVID-19 in the intensive care unit (ICU).


Do ICU patients with COVID-19 require a high amount of sedation or paralysis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Question and Answer Webcast Series - Webcast 2 held on April 10, 2020.


Clinical Perspectives: The Front Lines

This webinar discusses COVID-19 cases from the front-line at the University of Nebraska Medical Center Recorded on: April 17, 2020


Diagnosis and Management of Acute Respiratory Failure

Point of Care (PoC) Refresher Training. While current recommendations for respiratory support in COVID-19 support the use of the high-flow nasal cannula for hypoxia, oxygen supplementation strategies vary by institution. Make sure to follow your institution's protocols.