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Category: Pharmacology

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SCCM Pod-383 Anticoagulant Reversal

Ranjit Deshpande, MD, and Mark D. Cipolle, MD, PhD, FCCM, discuss Dr. Cipolle's talk from the 48th Critical Care Congress on what's new in anticoagulant reversal.

Tune in to hear about the hottest topics and current research.

Dr. Cipolle is director of outcomes research and surgical service line at Christiana Care Health System in Newark, Delaware, USA.

SCCM Pod-378 Procalcitonin Guidance during Antibiotics Management

Ranjit Deshpande, MD, and Simon W. Lam, PharmD, MS, BCPS, BCCCP, FCCM, discuss procalcitonin guidance during different phases of antibiotics management in patients admitted to intensive care units.

This podcast originated from the article "Systematic Review and Meta-Analysis of Procalcitonin-Guidance Versus Usual Care for Antimicrobial Management in Critically Ill Patients: Focus on Subgroups Based on Antibiotic Initiation, Cessation, or Mixed Strategies" (Lam S, et al. Crit Care Med. 2018;46:684-690).

Dr. Lam is a clinical specialist in pharmacoeconomics, outcomes research, and critical care at the Cleveland Clinic in Cleveland, Ohio, USA. He has no disclosures to report.

This podcast is sponsored by Thermo Fisher Scientific.

SCCM Pod-368 Achieving Fluid Balance

Kyle Enfield, MD, speaks with Colin K. Grissom, MD, FCCM, and Matthew W. Semler, MD, about fluid management in the critically ill. Dr. Grissom presented his talk, entitled “Achieving Fluid Balance,” at the 47th Critical Care Congress in San Antonio, Texas. During this session he discussed the study by Semler et al. entitled “Balanced Crystalloids versus Saline in Critically Ill Adults,” published in the March 2018 issue of the New England Journal of Medicine. Dr. Grissom and Dr. Semler discuss the history of fluid management in the critically ill and how recent study findings are shaping future care. Dr. Grissom works as an attending physician at Intermountain Medical Center in Salt Lake City, Utah. Dr. Semler works as an attending physician at Vanderbilt University Medical Center in Nashville, Tennessee. Released: 8/9/18

SCCM Pod-361 Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration

Dr. Fraser, MD, speaks with Jean Baptiste Lascarrou, MD, about the article, "Antibiotic Therapy in Comatose Mechanically Ventilated Patients Following Aspiration: Differentiating Pneumonia from Pneumonitis," published in Critical Care Medicine.

He discusses results from his team’s prospective observational study to determine the proportion of patients with documented bacterial aspiration pneumonia among comatose ICU patients with symptoms suggesting either bacterial aspiration pneumonia or non-bacterial aspiration pneumonitis.

Dr. Lascarrou is a physician in the Medical Intensive Care Unit at CHU Nantes in Nantes, France. Crit Care Med. 2017; 45(8):1268-1275.

SCCM Pod-317 Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients

Todd Fraser, MD, speaks with Nick Daneman, MD, about the article, “Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients,” published in Critical Care Medicine. Dr. Daneman is a scientist in the Evaluative Clinical Sciences, Trauma, Emergency & Critical Care Research Program at Sunnybrook Research Institute, and Assistant Professor of Medicine at the University of Toronto in Toronto, Ontario, Canada. In this article, Dr. Daneman and coauthors discuss duration of antimicrobial treatment provided to patients who have bacteremia in ICUs, and assess pathogen/patient factors related to treatment duration and the relationship between duration and survival.

SCCM Pod-313 Idarucizumab for Dabigatran Reversal

Margaret Parker, MD, MCCM, speaks with SCCM President Todd Dorman, MD, FCCM. Dr. Dorman is Senior Associate Dean for Education Coordination, Associate Dean of Continuing Medical Education, and Professor and Vice Chair for Critical Care. He holds joint appointments in Medicine, Surgery and the School of Nursing at Johns Hopkins University School of Medicine in Baltimore, Maryland. Dr. Dorman discusses some of the challenges facing the critical care community today, as well as goals he would like to accomplish during his tenure as President.

SCCM Pod-309 Overall Hypothermia Update

Margaret Parker, MD, MCCM, speaks with Benjamin Abella, MD, about his upcoming talk, “Overall Hypothermia Update,“ which he will present at the 45th Critical Care Congress as part of the Society’s Current Concepts in Adult Critical Care Pre-Course. Dr. Abella is Associate Professor of Emergency Medicine and Vice Chair of Research in the Department of Emergency Medicine at the University of Pennsylvania in Philadelphia, Pennsylvania. Dr. Abella discusses current hypothermia guidelines, the use of hypothermia as a treatment following cardiac arrest, and the benefits and challenges of implementing targeted temperature management protocols.

SCCM Pod-237 Evaluation of a Pharmacist-Managed Methadone Taper in the PICU

Margaret Parker, MD, MCCM, speaks with Katherine J. Steineck, PharmD, pediatric clinical pharmacist at the University of Minnesota Amplatz Children’s Hospital. They discuss the article published in Pediatric Critical Care Medicine, “Evaluation of a Pharmacist-Managed Methadone Taper.” In this article, Dr. Steineck and coauthors evaluate the efficacy of pharmacist-managed methadone taper as to previous prescribing practices.

SCCM Pod-157 Sedation Strategies in the ICU

Troy E. Batterton, PharmD, a pharmacist at Lakeland Regional Medical Central, and Dean Sandifer, MD, an internist, both practicing at Lakeland Regional Medical Center in Lakeland, Florida, discuss sedation strategies in critical care, including designing, building and maintaining protocols in intensive care units.

SCCM Pod-93 ACCM Recommendations for Corticosteroid Insufficiency

Paul Marik, MD, FCCM, discusses the June Critical Care Medicine article, "Recommendations for the Diagnosis and Management of Corticosteroid Insufficiency in Critically Ill Adult Patients: Consensus Statements from an International Task Force by the American College of Critical Care Medicine."  Marik is the chief of pulmonary and critical care medicine at Thomas Jefferson University in Philadelphia, Pennsylvania, USA.

SCCM Pod-58 CC: Cardiology Pharmacotherapies

Frederick P. Ognibene, MD, FCCM, discusses his goals as the Society's president for 2007 as well as his decades-long involvement in SCCM and the critical care community. Dr. Ognibene is director of the office of clinical research training and medical education at the National Institutes of Health (NIH) Clinical Center and the director of clinical research training program, OIR. He also is an attending in the medical intensive care unit at the NIH Clinical Center. 

SCCM Pod-40 CCM: Initial Antimicrobial Treatment of MRSA

Marin Kollef, MD, professor of medicine in the department of pulmonary and critical care medicine at the Washington University School of Medicine and director of medical critical care at Barnes-Jewish Hospital, discusses his article in the August issue of Critical Care Medicine, "Methicillin-Resistant Staphylococcus aureus Sterile-Site Infection: The Importance of Appropriate Initial Antimicrobial Treatment."

SCCM Pod-34 CCM: Lorazepam vs. Propofol

Shannon S. Carson, MD, assistant professor of medicine at the University of North Carolina at Chapel Hill and associate medical director of the medical and respiratory ICUs at the UNC Medical Center, as well as John P. Kress, MD, assistant professor of medicine at the University of Chicago, discuss their article from the May 2006 Critical Care Medicine, "A Randomized Trial of Intermittent Lorazepam vs. Propofol With Daily Interruption in Mechanically Ventilated Patients."

SCCM Pod-31 CC: Prophylactic Antimicrobial Use in the ICU

Phil Barie, MD, MBA, FCCM, discusses his article from the April 2006 issue of Critical Connections on antibiotic prophylaxis. He addresses when this therapy is most useful as well as the consequences of overuse. Dr. Barie is professor of surgery and public health at Weill Medical College of Cornell University in New York City, and he sits on the executive committee of the Society of Critical Care Medicine.

Concise Critical Appraisal: Antipsychotic Medications for Delirium in the ICU

Girard et al (N Engl J Med. 2018;379:2506-2516) and Page et al (Lancet Respir Med. 2013;1:515-523) evaluated the treatment of acute delirium with antipsychotics.

Concise Critical Appraisal: Early Sedation Using Dexmedetomidine in Critically Ill Patients

Shehabi et al (N Engl J Med. 2019;380:2506-2517) set out to examine the effects of using dexmedetomidine as the primary agent for early sedation among patients receiving ventilatory support and found that the dexmedetomidine group had a higher risk of adverse events and needed additional sedatives to achieve sedation goals.

Dexmedetomidine-Associated Hyperpyrexia in Three Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations. In this study of three patients, the authors state that their findings suggest that high doses of dexmedetomidine infusion are associated with hyperpyrexia in a seemingly dose-dependent fashion in critically ill patients with coronavirus disease 2019.

Can antiplatelets be administered at the same time as anticoagulation in patients with COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021

Can children be anticoagulated or only adults?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on February 24, 2021

PANDEM Guidelines for Infants and Children  

Ped Crit Care Med 2022 Feb;23(2):e74-e110