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Category: Hematology

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SCCM Pod-64 2007 Congress Special: Anemia in the ICU

Howard Corwin, MD, FCCM, discusses hematological issues and anemia in the critically ill and injured. Dr. Corwin professor of medicine and section chief of critical care medicine at Dartmouth-Hitchcock Medical Center in New Hampshire and presented during the 36th Critical Care Congress on this topic. 

Concise Critical Appraisal: Cerebral Oxygen Metabolism and RBC Transfusion in Infants

Neunhoeffer et al (Pediatr Crit Care Med. 2018;19:318-327) sought to use noninvasive means to determine the changes in cerebral oxygen metabolism in infants younger than 6 months who have undergone major surgery.  

Anti-Factor Xa-Based Monitoring of Unfractionated Heparin

Saini et al (J Pediatr. 2019;209:212-219.e1) sought to evaluate the clinical outcomes in pediatric patients receiving unfractionated heparin while being monitored using anti-factor Xa and to determine the correlation between anti-factor Xa, heparin, and activated partial thromboplastin time.

Concise Critical Appraisal: Early Use of Tranexamic Acid in the Treatment of Gastrointestinal Bleeds

This Concise Critical Appraisal offers a deep dive into the HALT-IT trial, which investigated whether early use of tranexamic acid to treat acute severe gastrointestinal bleeds would reduce overall mortality while limiting the burden of thromboembolic events.

SCCM Pod-423 Coagulopathy in COVID-19 Patients

COVID-19 is associated with a high prevalence of coagulopathy and venous thromboembolism. Host Kyle B. Enfield, MD, FCCM, talks with Jerrold H. Levy, MD, FAHA, FCCM, about what clinicians need to know about this serious problem and how it impacts care delivery (Iba et al. Crit Care Med. 2020;48:1358-1364). Dr. Levy is professor of anesthesiology, critical care professor of surgery (cardiothoracic), and codirector of the cardiothoracic ICU at Duke University Hospital in Durham, North Carolina, USA. This podcast is sponsored by BioFire.

SCCM Pod-383 Anticoagulant Reversal

Ranjit Deshpande, MD, and Mark D. Cipolle, MD, PhD, FCCM, discuss Dr. Cipolle's talk from the 48th Critical Care Congress on what's new in anticoagulant reversal.

Tune in to hear about the hottest topics and current research.

Dr. Cipolle is director of outcomes research and surgical service line at Christiana Care Health System in Newark, Delaware, USA.

SCCM Pod-283 Transfusion Triggers for Guiding RBC Transfusion for Cardiovascular Surgery

Michael S. Weinstein, MD, FACS, FCCM, speaks with C. David Mazer, MD, FRCPC, and Gerard F. Curley, MB, MSc, PhD, FCARCSI, about the article, “Transfusion Triggers for Guiding RBC Transfusion for Cardiovascular Surgery: A Systematic Review and Meta-Analysis*,” published in Critical Care Medicine. In this article, the authors investigate whether perioperative restrictive transfusion thresholds are associated with inferior clinical outcomes in randomized trials of cardiovascular surgery patients.

SCCM Pod-236 Are Pediatric Intensivists Changing Their Transfusion Practices?

Margaret Parker, MD, MCCM, speaks with Jacques R. Lacroix, MD, about the article, "Survey on Stated Transfusion Practices in Pediatric Intensive Care Units," published in Pediatric Critical Care Medicine. Dr. Lacroix helped conduct a study among North American and European pediatric intensivists to find that stated transfusion practice patterns appear to be evolving toward a more restrictive approach two and a half years after the publication of the Transfusion Requirement in PICU trial. Dr. Lacroix is professor of Pediatrics at the University of Montreal and chair of acute care access at Sainte-Justine Hospital in Montreal, Quebec.

SCCM Pod-167 PCCM: Restrictive Versus Liberal Transfusion Strategy in Children

Jill M. Cholette, MD, is the lead author of an article published in the January Pediatric Critical Care Medicine titled, “Children with Single-Ventricle Physiology Do Not Benefit From Higher Hemoglobin Levels Post Cavopulmonary Connection: Results of a Prospective, Randomized, Controlled Trial of a Restrictive Versus Liberal Red-Cell Transfusion Strategy.” The study found that a restrictive red blood cell transfusion strategy decreases the number of transfusions, donor exposures and potential risks in these children. Cholette is an assistant professor of pediatrics in the division of pediatric critical care medicine at the University of Rochester Medical Center in Rochester, New York.

SCCM Pod-150 PCCM: Blood Transfusion and Prolonged Mechanical Ventilation

Ravi Thiagarajan, MD, MBBS, MPH, discusses his article published in the January Pediatric Critical Care Medicine titled, “Blood Transfusion is Associated with Prolonged Duration of Mechanical Ventilation in Infants Undergoing Reparative Cardiac Surgery.” Thiagarajan is an assistant professor of pediatrics at Children’s Hospital Boston.

SCCM Pod-143 PCCM: The Effects of Heparin in Infants After Catheter-Related Thrombosis

Alan R. Schroeder, MD, discusses his article, “A Continuous Heparin Infusion Does Not Prevent Catheter-Related Thrombosis in Infants After Cardiac Surgery," published in the July Pediatric Critical Care Medicine. Schroeder is the chief of pediatric inpatient services at Santa Clara Valley Medical Center in San Jose, California. 

SCCM Pod-57 CCM: Heparin-Induced Thrombocytopenia

Stanley Nasraway, MD, FCCM, discusses an article in the December issue of Critical Care Medicine "Heparin-induced thrombocytopenia in the critical care setting: Diagnosis and management." 

SCCM Pod-502: Current Concepts: Hemostatic Resuscitation for Traumatic and Nontraumatic Hemorrhage

This is the second episode of SCCM’s Current Concepts Series, in which authors unveil exclusive insights into the 2024 Current Concepts Course. Diane C. McLaughlin, DNP, AGACNP-BC, CCRN, FCCM, is joined by Nasim Motayar, MD, to discuss updates in hemostatic resuscitation for traumatic and nontraumatic hemorrhage. Dr. Motayar offers a concise overview of this Current Concepts chapter, providing valuable takeaways for healthcare professionals looking to enhance their clinical practice.

Have you considered lymphopenia as a criterion to suspect COVID-19?

In this question and answer webcast series, attendees had an opportunity to pose questions about managing critically ill patients with COVID-19 and other issues. Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were also answered. Recorded on: Friday, May 22, 2020

Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Medicine. The authors reviewed thromboelastography studies in critically ill patients with coronavirus disease 2019 to characterize their coagulation states.

Letter to the Editor Treatment of Critically Ill Coronavirus Disease 2019 Patients With Adjunct Therapeutic Plasma Exchange: A Single-Center Retrospective Case Series

From Critical Care Explorations. In this Letter to the Editor, the authors describe their experience with a series of eight patients receiving adjunct therapeutic plasma exchange for severe coronavirus disease pneumonia complicated by sepsis with multiple organ dysfunction in which C-reactive protein and ferritin levels significantly decreased with therapeutic plasma exchange, whereas D-dimer decreased to a lesser degree.

Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019

From Critical Care Explorations. The authors sought to determinewhether placental cell therapy PLacental eXpanded (PLX)-PAD (Pluristem Therapeutics, Haifa, Israel) was beneficial to treating critically ill patients suffering from acute respiratory distress syndrome due to coronavirus disease 2019.

Probative Value of the D-Dimer Assay for Diagnosis of Deep Venous Thrombosis in the Coronavirus Disease 2019 Syndrome

From Critical Care Medicine.The authors describe the predictive utility of the D-dimer assay among patients with the coronavirus disease 2019 syndrome for unprovoked lower extremity deep venous thrombosis.

Thromboelastography to Detect Hypercoagulability and Reduced Fibrinolysis in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients

From Critical Care Explorations. In this study, the authors investigated thromboelastography in patients with coronavirus disease 2019-associated acute respiratory distress syndrome with the goal of characterizing suspected coagulopathy and impaired fibrinolysis.

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation

From Critical Care Explorations. The authors found that thrombosis profiling identified endothelial activation and glycocalyx degradation in coronavirus disease 2019 positive patients and believe that the data from this study suggest that medications to protect and/or restore the endothelial glycocalyx, as well as platelet inhibitors, should be considered for further study.