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SARI-PREP is a multicenter consortium funded by the CDC Foundation. It is being assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches.
Specific causes of severe acute respiratory infection (SARI) to be targeted by SARI-PREP include SARS-CoV-2, influenza A and B viruses, and other known or novel viral infections causing outbreaks, epidemics, and pandemics of SARI.
The information gained will help to rapidly inform and improve clinical management of epidemic/pandemic SARI patients. The completion date is September 2023. The National Clinical Trial number is NCT04786301.
Society of Critical Care Medicine contact: Vishakha Kumar, MD, MBA.
Identify the clinical characteristics and treatments associated with risk for severity of disease and important clinical outcomes in hospitalized patients at high risk for SARI due to respiratory viral illness caused by pathogens such as SARS-CoV-2 and influenza A and B viruses
Identify clinical characteristics and treatments differentiating patients with SARI due to specific respiratory viruses such as SARS-CoV-2 and influenza A among hospitalized patients with suspected viral SARI
Identify the molecular markers of risk for poor in-hospital and post-discharge clinical outcomes in hospitalized patients with viral SARI
Evaluate which patient characteristics and treatments are associated with organ failure-free days and mortality in patients with viral SARI
Report the natural history of a large cohort of patients with confirmed viral SARI
Central institutional review board (IRB) will be through the University of Nebraska. For additional IRB information, please contact SCCM staff.
Inclusion criteria:
At-risk cohort requires admission to an acute care or intensive care unit with a clinical syndrome of lower respiratory tract infection suspicious for viral SARI. This will be defined by the presence of fever, cough, and radiographic infiltrates by imaging (e.g., chest radiograph, CT) or Spo2 ≤ 94% on room air or requiring new supplemental oxygen (above baseline if preexisting) or requiring invasive or noninvasive mechanical ventilation.
Case cohort requires the criteria above plus confirmed viral cause for SARI by respiratory viral reverse transcription polymerase chain reaction testing.
Exclusion criteria:
Prisoners or wards of the state
Inability to consent or lack of availability of legal surrogate
Status of do-not-attempt resuscitation or do-not-intubate on admission
University of Washington Medical Center
Seattle, Washington, USA
Co-Investigators
Press releases and news articles highlighting SARI-PREP activities.
Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic
Anesi GL, Andrews A, Bai H, et al; for the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group. Perceived hospital stress, severe acute respiratory syndrome coronavirus 2 activity, and care process temporal variance during the COVID-19 pandemic. Crit Care Med. 2023 Feb 15. doi: 10.1097/CCM.0000000000005802. Online ahead of print.
Program Type:
Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections
Postelnicu R, Srivastava A, Bhatraju PK, et al; Society of Critical Care Medicine Discovery Network Investigators. Severe Acute Respiratory Infection—Preparedness: protocol for a multicenter prospective cohort study of viral respiratory infections. Crit Care Explor: 2022 Oct 20;4(10):e0773. doi: 10.1097/CCE.0000000000000773
Program Type:
Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome
Sulaiman I, Chung M, Angel L, et al. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258.
Program Type:
Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events
Anesi G, Sevransky J, Cobb J, Evans L. Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events. 2021 Jun.
Program Type:
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Bhatraju PK, Morrell ED, Zelnick L, Sathe NA, Chai XY, Sakr SS, Sahi SK, Sader A, Lum DM, Liu T, Koetje N, Garay A, Barnes E, Lawson J, Cromer G, Bray MK, Pipavath S, Kestenbaum BR, Liles WC, Fink SL, West TE, Evans L, Mikacenic C, Wurfel MM. Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study. Crit Care. 2021 Apr 19;25(1):148.
Program Type:
George L. Anesi, MD, MSCE, MBE, discusses how SARI-PREP is gathering qualitative data from study sites to answer questions on how hospital strain has influenced usual operations and staffing.
Leopoldo Segal, MD, shares how his research lab developed novel ways to investigate what COVID-19 does in the body, especially the lungs.