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Discovery, the Critical Care Research Network Publications
Improving Outcomes in Mechanically Ventilated Adult ICU Patients Following Implementation of the ICU Liberation (ABCDEF) Bundle Across a Large Healthcare System
Barr J, Downs B, Ferrell K, et al. Improving outcomes in mechanically ventilated adult ICU patients following implementation of the ICU Liberation (ABCDEF) bundle across a large healthcare system. Crit Care Explor. 2024 Jan 19;6(1):e1001. doi: 10.1097/cce.0000000000001001.
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Association of Active Renin Content With Mortality in Critically Ill Patients: A Post Hoc Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Trial
Busse LW, Schaich CL, Chappell MC, et al; Vitamin C, Thiamine, and Steroids in Sepsis (VICTAS) Investigators. Association of active renin content with mortality in critically ill patients: a post hoc analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Trial. Crit Care Med. 2023 Nov 10. Online ahead of print. doi: 10.1097/CCM.0000000000006095.
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Biomarker-Concordant Steroid Administration in Severe Coronavirus Disease-2019
Tekin A, Domecq JP, Morales DJV, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. J Intensive Care Med. 2023 Nov;38(11):1003-1014. doi: 10.1177/08850666231177200. Epub 2023 May 24.PMID: 37226483
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Effects of Timing of Invasive Mechanical Ventilation in Patients With Shock. An Analysis of the Multicenter Prospective Observational VOLUME-CHASERS Cohort
Goel NN, Chen JT, Roberts R, Sevransky J, Gong MN, Mathews KS; VOLUME-CHASERS Study Group; Society of Critical Care Medicine Discovery Network. Effects of timing of invasive mechanical ventilation in patients with shock. An analysis of the multicenter prospective observational VOLUME-CHASERS cohort. J Intensive Care Med. 2022 Nov;37(11):1435-1441. doi: 10.1177/08850666221081102.
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The Association of Early Systemic Corticosteroids and Secondary Infection Amongst Hospitalized COVID-19 Patients: Results from the SCCM Discovery Virus COVID-19 Registry
Bansal VB, Jain NK, Lal A, Domecq JP, Tekin A, Mir M, Attallah JN, Hassan E, Ahmed H, Anwar M, Khedr A, Kumar V, Robinson S, Kondori MJ, Koritala T, Boman K, Cartin-Ceba R, Christie A, Armaignac D, La Nou A, Sanghavi D, Walkey AJ, Kashyap R, Khan SA. The Association of Early Systemic Corticosteroids and Secondary Infection Amongst Hospitalized COVID-19 Patients: Results from the SCCM Discovery Virus COVID-19 Registry. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Impact of Early Tracheostomy on Hospitalization Outcomes in Mechanically Ventilated COVID-19 Patients
Isha S, Khadka S, Shrestha R, Satashia P, Balasubramanian P, Jenkins A, Hanson A, Singh K, Jena A, Tekin A, Bansal V, Kashyap R, Balavenkataraman A, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Impact of Early Tracheostomy on Hospitalization Outcomes in Mechanically Ventilated COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Early Tracheostomy is Associated with Improved Mobility and Shorter Duration of Sedative-Analgesic Use in Critically Ill COVID-19 Patients
Satashia P, Isha S, Shrestha R, Khadka S, Balasubramanian P, Singh K, Jena A, Jenkins A, Hanson A, Tekin A, Bansal V, Kashyap R, Balavenkataraman A, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Shapiro AB, Chaudhary S, Bhattacharyya A, Guru PK, Moreno Franco P, Sanghavi D. Early Tracheostomy Is Associated With Improved Mobility and Shorter Duration of Sedative-Analgesic Use in Critically Ill COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Incidence of Post-Intubation Complications in Early vs Late-Tracheostomy in Hospitalized COVID-19 Patients
Khadka S, Isha S, Shrestha R, Satashia P, Balasubramanian P, Hanson A, Jenkins A, Jena A, Singh K, Balavenkataraman A, Tekin A, Bansal V, Kashyap R, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Incidence of Post-Intubation Complications in Early vs Late-Tracheostomy in Hospitalized COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Outcomes Associated with Early Initiation of Inhaled Nitric Oxide in Hospitalized COVID-19 Patients
Isha S, Vasudhar A, Khadka S, Jonna S, Sinclair de Frías J, Satashia P, Balasubramanian P, Jenkins A, Hanson A, Balavenkataraman A, Tekin A, Bansal V, Kashyap R, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Outcomes Associated with Early Initiation of Inhaled Nitric Oxide in Hospitalized COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Improvement of Oxygenation Status with Inhaled Nitric Oxide Therapy in Hospitalized COVID-19 Patients: A Retrospective Study
Balasubramanian P, Isha S, Jonna S, Khadka S, Vasudhar A, Sinclair de Frías J, Satashia P, Jenkins A, Hanson A, Balavenkataraman A, Tekin A, Bansal V, Kashyap R, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Improvement of Oxygenation Status with Inhaled Nitric Oxide Therapy in Hospitalized COVID-19 Patients: A Retrospective Study. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Mechanical Ventilation Practice and Outcomes of Patients with Obesity and Acute Respiratory Distress Syndrome from COVID-19
Hutton A, Takkouche S, Ramachandran R, Kim YI, Khan SA, Denson JL, Bansal V, Kumar V, Walkey AJ, Kashyap R, Bjornstad E, Gandotra S. Mechanical Ventilation Practice and Outcomes of Patients with Obesity and Acute Respiratory Distress Syndrome from COVID-19. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Hospital Variations in Limitations of Care Among Hospitalized Patients with COVID-19: Results from the SCCM Discovery Virus COVID-19 Registry Study
Hutton A, Takkouche S, Ramachandran R, Kim YI, Khan SA, Denson JL, Bansal V, Kumar V, Walkey AJ, Kashyap R, Bjornstad E, Gandotra S. Mechanical Ventilation Practice and Outcomes of Patients with Obesity and Acute Respiratory Distress Syndrome from COVID-19. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
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Validation of Automated Data Abstraction for SCCM Discovery VIRUS COVID-19 Registry: Practical EHR Export Pathways (VIRUS-PEEP)
Morales DJV, Bansal V, Heavner SF, et al. Validation of automated data abstraction for SCCM Discovery VIRUS COVID-19 registry: practical EHR export pathways (VIRUS-PEEP). Front. Med (Lausanne). 2023 Oct 4:10:1089087. doi: 10.3389/fmed.2023.1089087.
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Variation in Fluid and Vasopressor Use in Shock With and Without Physiologic Assessment: A Multicenter Observational Study
Chen JT, Roberts R, Fazzari MJ, et al; VOLUME-CHASERS Study Group; Society of Critical Care Medicine Discovery Network. Variation in fluid and vasopressor use in shock with and without physiologic assessment: a multicenter observational study. Crit Care Med. 2020 Oct;48(10):1436-1444. doi: 10.1097/CCM.0000000000004429.
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Assessment of implementation methods in sepsis: study protocol for a cluster-randomized hybrid type 2 trial
Frank HE, Evans L, Phillips G, et al. Assessment of implementation methods in sepsis: study protocol for a cluster-randomized hybrid type 2 trial. Trials. 2023 Sep 29;24(1):620. https://doi.org/10.1186/s13063-023-07644-y
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Humanizing the Intensive Care Unit: Perspectives of Patients and Families on the Get to Know Me Board
Ahmad SR, Rhudy L, Fogelson LA, et al. Humanizing the intensive care unit: perspectives of patients and families on the get to know me board. J Patient Exp. 2023 Sep 18;10:23743735231201228. doi: 10.1177/23743735231201228.
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Caring for Critically Ill Children With the ICU Liberation Bundle (ABCDEF): Results of the Pediatric Collaborative
Lin JC, Srivastava A, Malone S, et al; Society of Critical Care Medicine’s Pediatric ICU Liberation Campaign Collaborative. Caring for critically ill children with the ICU Liberation Bundle (ABCDEF): results of the pediatric collaborative. Pediatr Crit Care Med. 2023 Aug 1;24(8):636-651. doi: 10.1097/PCC.0000000000003085.
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Development and Validation of an Acute Respiratory Distress Syndrome Prediction Model in Coronavirus Disease 2019: Updated Lung Injury Prediction Score
Tekin A, Qamar S, Sharma M, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Development and validation of an acute respiratory distress syndrome prediction model in coronavirus disease 2019: updated lung injury prediction score. Mayo Clin Proc. 2023 May;98(5):736-747. doi: 10.1016/j.mayocp.2022.11.021.
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Weaning From Mechanical Ventilation in Intensive Care Units Across 50 Countries (WEAN SAFE): A Multicentre, Prospective, Observational Cohort Study
Pham T, Heunks L, Bellani G, et al; WEAN SAFE Investigators. Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study. Lancet Respir Med. 2023 May;11(5):465-476. doi: 10.1016/S2213-2600(22)00449-0.
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A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools
Heavner SF, Anderson W, Kashyap R, et al. A path to real-world evidence in critical care using open-source data harmonization tools. Crit Care Explor. 2023 Apr 3;5(4):e0893. doi: 10.1097/CCE.0000000000000893.
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Coronavirus Disease 2019 in Pediatric Oncology Patients: A Matched-Cohort Analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry
Balakumar N, Catueno S, Nadiger M, et al. Coronavirus disease 2019 in pediatric oncology patients: a matched-cohort analysis of the SCCM Discovery Viral Infection and Respiratory Illness Universal Study COVID-19 Registry. J Pediatr Hematol Oncol. 2023 Apr 1;45(3):e309-e314. doi: 10.1097/MPH.0000000000002588.
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Facilitators and Barriers to the Implementation of New Critical Care Practices During COVID-19: A Multicenter Qualitative Study Using the Consolidated Framework for Implementation Research (CFIR)
Silver S, Jones KC, Redmond S, et al. BMC Health Serv Res. 2023 Mar 20;23(1):272. doi: 10.1186/s12913-023-09209-w.
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WEAN SAFE and the Definition of the First Separation Attempt
Cuyas CS, Fernández RF. WEAN SAFE and the definition of the first separation attempt. Lancet Respir Med. 2023 May;11(5):e43. doi: https://doi.org/10.1016/S2213-2600(23)00051-6.
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A Multisite Exploration of the Association Between Critical Care Implementation Factors and Clinical Outcomes During the COVID-19 Pandemic
Silver S, Redmond S, Jones KC, et al. J Clin Transl Sci. 2023 Feb 17;7(1):e72. doi: 10.1017/cts.2023.22.
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Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic
Anesi GL, Andrews A, Bai H, et al; for the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group. Perceived hospital stress, severe acute respiratory syndrome coronavirus 2 activity, and care process temporal variance during the COVID-19 pandemic. Crit Care Med. 2023 Feb 15. doi: 10.1097/CCM.0000000000005802. Online ahead of print.
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Implementation of a Multimodal Knowledge-Exchange Platform to Provide Trauma Critical Care Education During the Ongoing Conflict in Ukraine
Rovati L, Zec S, Dziuba D, et al. Implementation of a multimodal knowledge-exchange platform to provide traum critical care education during the ongoing conflict in Ukraine. JAMA Netw Open. 2023 Feb 1;6(2):e230050. doi: 10.1001/jamanetworkopen.2023.0050.
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Association of Vitamin C, Thiamine, and Hydrocortisone Infusion With Long-term Cognitive, Psychological, and Functional Outcomes in Sepsis Survivors: A Secondary Analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial
Roberson SW, Nwosu S, Collar EM, et al; VICTAS Investigators. Association of vitamin C, thiamine, and hydrocortisone infusion with long-term cognitive, psychological, and functional outcomes in sepsis survivors: a secondary analysis of the Vitamin C, Thiamine, and Steroids in Sepsis Randomized Clinical Trial. JAMA Netw Open. 2023 Feb 1;6(2):e230380. doi: 10.1001/jamanetworkopen.2023.0380. Erratum in: JAMA Netw Open. 2023 Apr 3;6(4):e2312173.
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Leveraging the SCCM Discovery VIRUS COVID-19 Registry to Evaluate Drug Repurposing Research Dataset
Heavner S, Howard K, Pauley M, et al. Leveraging the SCCM Discovery VIRUS COVID-19 Registry to evaluate drug repurposing research dataset. Abstract 1126. Presented at Society of Critical Care Medicine Annual Congress, January 23, 2023. Crit Care Med. 2023 Jan;51(1):561. doi: 0.1097/01.ccm.0000910240.21305.8d.
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Angiopoietin-Like4 Is a Novel Marker of COVID-19 Severity
Bhatraju PK, Morrell ED, Stanaway IB, et al. Crit Care Explor. 2022 Dec 30;5(1):e0827. doi: 10.1097/CCE.0000000000000827.
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Variations in Administrative Approvals During the COVID-19 Pandemic at Participating Sites in the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study: COVID-19 Registry: A Cross-Sectional Study
Bansal V, Sharma M, Deo N, et al. Crit Care Explor. 2022 Dec 16;4(12):e0822. doi: 10.1097/CCE.0000000000000822.
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The Impact of Steroids on Outcomes of Children Admitted to the Hospital With Non-MISC COVID-19: An Analysis from the SCCM Discovery Network Virus Registry
Nadiger M, Harthan A, McGarvey JS, et al. The impact of steroids on outcomes of children admitted to the hospital with Non-MISC COVID-19: an analysis from the SCCM Discovery Network Virus Registry. Pediatric Critical Care Medicine Conference: 11th Congress of the World Federation of Pediatric Intensive and Critical Care Societies (WFPICCS). 2022;23(11 Supplement 1).
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Association of Early Steroid Administration With Outcomes of Children Hospitalized for COVID-19 Without Multisystem Inflammatory Syndrome in Children
Tripathi S, Nadiger M, McGarvey JS, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of early steroid administration with outcomes of children hospitalized for COVID-19 without multisystem inflammatory syndrome in children. JAMA Pediatr. 2022 Oct 3. Online ahead of print. doi:10.1001/jamapediatrics.2022.3611.
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Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections
Postelnicu R, Srivastava A, Bhatraju PK, et al; Society of Critical Care Medicine Discovery Network Investigators. Severe Acute Respiratory Infection—Preparedness: protocol for a multicenter prospective cohort study of viral respiratory infections. Crit Care Explor: 2022 Oct 20;4(10):e0773. doi: 10.1097/CCE.0000000000000773
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Pre-Hospital Aspirin Use and Patient Outcomes in COVID-19: Results From the International Viral Infection and Respiratory Illness Universal Study (VIRUS)
Lal A, Garces JP, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pre-hospital aspirin use and patient outcomes in COVID-19: results from the International Viral Infection and Respiratory Illness Universal Study (VIRUS). Arch Bronconeumol. 2022 Sep 8;S0300-2896(22)00510-5. Online ahead of print. doi:10.1016/j.arbres.2022.07.017.
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Gastrointestinal Manifestations in Hospitalized Children With Acute SARS-CoV-2 Infection and Multisystem Inflammatory Condition: An Analysis of the VIRUS COVID-19 Registry
Sayed IA, Bhalala U, Strom L, et al; VIRUS Investigators. Pediatr Infect Dis J. 2022 Sep 1;41(9):751-758. doi:10.1097/INF.0000000000003589.
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Variation in Use of High-Flow Nasal Cannula and Noninvasive Ventilation Among Patients With COVID-19
Garcia MA, Johnson SW, Sisson EK, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Respir Care. 2022 Aug;67(8):929-938. doi:10.4187/respcare.09672.
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Five-Year Outcomes After Implementing a Pain, Agitation, and Delirium Protocol in a Mixed Intensive Care Unit
Fish JT, Baxa JT, Draheim RR, et al. Five-year outcomes after implementing a pain, agitation, and delirium protocol in a mixed intensive care unit. J Intensive Care Med. 2022 Aug;37(8):1060-1066. doi: 10.1177/08850666211063404.
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Association of Renin Angiotensin Aldosterone System Inhibitors and Outcomes of Hospitalized Patients With COVID-19
Gupta N, Settle L, Brown BR, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Crit Care Med. 2022 Jul 27. 10.1097/CCM.0000000000005627. Online ahead of print.
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Early Combination Therapy With Immunoglobulin and Steroids Is Associated With Shorter ICU Length of Stay in Multisystem Inflammatory Syndrome in Children (MIS-C) Associated With COVID19: A Retrospective Cohort Analysis From 28 U.S Hospitals
Harthan AA, Nadiger M, McGarvey JS, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Pharmacotherapy. 2022 Jul;42(7):529-539. doi:10.1002/phar.2709.
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Admission Code Status and End-of-Life Care for Hospitalized Patients With COVID-19
Kiker WA, Cheng S, Pollack LR, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. J Pain Symptom Manage. 2022 Jun 25;S0885-3924(22)00788-6. doi:10.1016/j.jpainsymman.2022.06.014.
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The Association of Latitude and Altitude With COVID-19 Symptoms: A VIRUS: COVID-19 Registry Analysis
Tekin A, Qamar S, Bansal V, et al. Open Respir Med J. 2022;16.
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Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic
Cervantes-Arslanian AM, Venkata C, Anand P, et al. Crit Care Explor. 2022 Apr 25;4(4):e0686. doi: 10.1097/CCE.0000000000000686.
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Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database
Turek JR, Bansal V, Tekin A, et al. JMIR Res Protoc. 2022 Mar 15;11(3):e27921. doi: 10.2196/27921.
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Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry
Tekin A, Qamar S, Singh R, et al; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi: 10.5492/wjccm.v11.i2.102.
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Association of Latitude and Altitude With Adverse Outcomes in Patients With COVID-19: The VIRUS Registry
Tekin A, Qamar S, Singh R, et al; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi:10.5492/wjccm.v11.i2.102.
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Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry
Deo N, Tekin A, Bansal V, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Int J Dermatol. 2022 May;61(5):623-625. doi: 10.1111/ijd.16134.
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Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19
Johnson SW, Garcia MA, Sisson EKQ, et al. Crit Care Explor. 2022 Feb 18;10(2):e0638. doi: 10.1097/CCE.0000000000000638.
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Association of hypothyroidism with outcomes in hospitalized adults with COVID‐19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry in Clinical Endocrinology
Bogojevic M, Bansal V, Pattan V, Singh R, Tekin A, Sharma M, La Nou AT, LeMahieu AM, Hanson AC, Schulte PJ, Deo N, Qamar S, Zec S, Valencia Morales DJ, Perkins N, Kaufman M, Denson JL, Melamed R, Banner-Goodspeed VM, Christie AB, Tarabichi Y, Heavner S, Kumar VK, Walkey AJ, Gajic O, Bhagra S, Kashyap R, Lal A, Domecq JP; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of hypothyroidism with outcomes in hospitalized adults with COVID-19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry. Clin Endocrinol (Oxf). 2022 Feb 18. doi: 10.1111/cen.14699.
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Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients
Cheruku SR, Barina A, Kershaw CD, Goff K, Reisch J, Hynan LS, Ahmed F, Armaignac DL, Patel L, Belden KA, Kaufman M, Christie AB, Deo N, Bansal V, Boman K, Kumar VK, Walkey A, Kashyap R, Gajic O, Fox AA; Society of Critical Care Medicine Discovery Viral Infection, Respiratory Illness Universal Study VIRUS: COVID-19 Registry Investigator Group. Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients. Resuscitation. 2021 Dec 14;170:230-237.
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Palliative Care Consultation and End-of-Life Outcomes in Hospitalized COVID-19 Patients
Cheruku SR, Barina A, Kershaw CD, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Resuscitation. 2022 Jan;170:230-237. doi:10.1016/j.resuscitation.2021.12.011.
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Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson JL, Gillet AS, Zu Y, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. JAMA Netw Open. 2021 Dec 1;4(12):e2140568. doi:10.1001/jamanetworkopen.2021.40568.
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Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19
Denson JL, Gillet AS, Zu Y, Brown M, Pham T, Yoshida Y, Mauvais-Jarvis F, Douglas IS, Moore M, Tea K, Wetherbie A, Stevens R, Lefante J, Shaffer JG, Armaignac DL, Belden KA, Kaufman M, Heavner SF, Danesh VC, Cheruku SR, St Hill CA, Boman K, Deo N, Bansal V, Kumar VK, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19. JAMA Netw Open. 2021 Dec 1;4(12):e2140568
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Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group
Garcia MA, Johnson SW, Bosch NA, Sisson EK, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Deo N, Domecq JP, Lal A, Christie AB, Banner-Goodspeed VM, Sanghavi D, Vadgaonkar G, Gajic O, Kashyap R, Walkey AJ. Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group. Crit Care Explor. 2021 Nov 2;3(11):e0566.
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Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry
Amer M, Kamel AM, Bawazeer M, Maghrabi K, Butt A, Dahhan T, Kseibi E, Khurshid SM, Abujazar M, Alghunaim R, Rabee M, Abualkhair M, Al-Janoubi A, AlFirm AT, Gajic O, Walkey AJ, Mosier JM, Zabolotskikh IB, Gavidia OY, Teruel SY, Bernstein MA, Boman K, Kumar VK, Bansal V, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry. Eur J Med Res. 2021 Oct 2;26(1):117.
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Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome
Sulaiman I, Chung M, Angel L, et al. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258.
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Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry
Tripathi S, Sayed IA, Dapul H, McGarvey JS, Bandy JA, Boman K, Kumar VK, Bansal V, Retford L, Cheruku S, Kaufman M, Heavner SF, Danesh VC, St Hill CA, Khanna AK, Bhalala U, Kashyap R, Gajic O, Walkey AJ, Gist KM. Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry. Crit Care Explor. 2021 Aug 20;3(8):e0514.
Program Type:
Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry
Bhalala US, Gist KM, Tripathi S, Boman K, Kumar VK, Retford L, Chiotos K, Blatz AM, Dapul H, Verma S, Sayed IA, Gharpure VP, Bjornstad E, Tofil N, Irby K, Sanders RC Jr, Heneghan JA, Thomas M, Gupta MK, Oulds FE, Arteaga GM, Levy ER, Gupta N, Kaufman M, Abdelaty A, Shlomovich M, Medar SS, Iqbal O'Meara AM, Kuehne J, Menon S, Khandhar PB, Miller AS, Barry SM, Danesh VC, Khanna AK, Zammit K, Stulce C, McGonagill PW, Bercow A, Amzuta IG, Gupta S, Almazyad MA, Pierre L, Sendi P, Ishaque S, Anderson HL 3rd, Nawathe P, Akhter M, Lyons PG, Chen C, Walkey AJ, Bihorac A, Wada Bello I, Ben Ari J, Kovacevic T, Bansal V, Brinton JT, Zimmerman JJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Characterization and Outcomes of Hospitalized Children With Coronavirus Disease 2019: A Report From a Multicenter, Viral Infection and Respiratory Illness Universal Study (Coronavirus Disease 2019) Registry. Crit Care Med. 2021 Aug 16.
Program Type:
Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events
Anesi G, Sevransky J, Cobb J, Evans L. Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events. 2021 Jun.
Program Type:
The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19
Tripathi S, Christison AL, Levy E, McGravery J, Tekin A, Bolliger D, Kumar VK, Bansal V, Chiotos K, Gist KM, Dapul HR, Bhalala US, Gharpure VP, Heneghan JA, Gupta N, Bjornstad EC, Montgomery VL, Walkey A, Kashyap R, Arteaga GM. The Impact of Obesity on Disease Severity and Outcomes Among Hospitalized Children with COVID-19. Hosp Pediatr. 2021 Jun 24:e2021006087. doi: 10.1542/hpeds.2021-006087.
Program Type:
Variation in Early Management Practices in Moderate-to-Severe ARDS in the United States: The Severe ARDS: Generating Evidence Study
Qadir N, Bartz RR, Cooter ML, et al; Severe ARDS: Generating Evidence (SAGE) Study Investigators; Society of Critical Care Medicine's Discovery Network. Variation in early management practices in moderate-to-severe ARDS in the United States: the Severe ARDS: Generating Evidence Study. Chest. 2021 Oct;160(4):1304-1315. doi: 10.1016/j.chest.2021.05.047.
Program Type:
Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources
Vukoja M, Dong Y, Adhikari NKJ, Schultz MJ, Arabi YM, Martin-Loeches I, Hache M, Gavrilovic S, Kashyap R, Gajic O; Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators of the SCCM Discovery Network and Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN) Investigators. Checklist for Early Recognition and Treatment of Acute Illness and Injury: An Exploratory Multicenter International Quality-Improvement Study in the ICUs With Variable Resources. Crit Care Med. 2021 Jun 1;49(6):e598-e612.
Program Type:
Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry
Tripathi S, Gist KM, Bjornstad EC, Kashyap R, Boman K, Chiotos K, Gharpure VP, Dapul H, Sayed IA, Kuehne J, Heneghan JA, Gupta M, Khandhar PB, Menon S, Gupta N, Kumar VK, Retford L, Zimmerman J, Bhalala US; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Coronavirus Disease 2019-Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry. Pediatr Crit Care Med. 2021 May 10.
Program Type:
Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Bhatraju PK, Morrell ED, Zelnick L, Sathe NA, Chai XY, Sakr SS, Sahi SK, Sader A, Lum DM, Liu T, Koetje N, Garay A, Barnes E, Lawson J, Cromer G, Bray MK, Pipavath S, Kestenbaum BR, Liles WC, Fink SL, West TE, Evans L, Mikacenic C, Wurfel MM. Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study. Crit Care. 2021 Apr 19;25(1):148.
Program Type:
The ARREST Pneumonia Clinical Trial. Rationale and Design
Levitt JE, Festic E, Desai M, et al; ARREST Pneumonia Clinical Trial Investigators. The ARREST pneumonia clinical trial. Rationale and design. Ann Am Thorac Soc. 2021 Apr;18(4):698-708. doi: 10.1513/AnnalsATS.202009-1115SD.
Program Type:
Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial
Sevransky JE, Rothman RE, Hager DN, Bernard GR, Brown SM, Buchman TG, Busse LW, Coopersmith CM, DeWilde C, Ely EW, Eyzaguirre LM, Fowler AA, Gaieski DF, Gong MN, Hall A, Hinson JS, Hooper MH, Kelen GD, Khan A, Levine MA, Lewis RJ, Lindsell CJ, Marlin JS, McGlothlin A, Moore BL, Nugent KL, Nwosu S, Polito CC, Rice TW, Ricketts EP, Rudolph CC, Sanfilippo F, Viele K, Martin GS, Wright DW; VICTAS Investigators. Effect of Vitamin C, Thiamine, and Hydrocortisone on Ventilator- and Vasopressor-Free Days in Patients With Sepsis: The VICTAS Randomized Clinical Trial. JAMA. 2021 Feb 23;325(8):742-750.
Program Type:
Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry
Domecq JP, Lal A, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Harhay MO, Garcia MA, Kaufman M, Danesh V, Cheruku S, Banner-Goodspeed VM, Anderson HL 3rd, Milligan PS, Denson JL, St Hill CA, Dodd KW, Martin GS, Gajic O, Walkey AJ, Kashyap R; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Outcomes of Patients With Coronavirus Disease 2019 Receiving Organ Support Therapies: The International Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2021 Mar 1;49(3):437-448.
Program Type:
Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry
Walkey AJ, Sheldrick RC, Kashyap R, Kumar VK, Boman K, Bolesta S, Zampieri FG, Bansal V, Harhay MO, Gajic O. Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry. Crit Care Med. 2020 Nov;48(11):e1038-e1044.
Program Type:
Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock
Roberts RJ, Miano TA, Hammond DA, Patel GP, Chen JT, Phillips KM, Lopez N, Kashani K, Qadir N, Cairns CB, Mathews K, Park P, Khan A, Gilmore JF, Brown ART, Tsuei B, Handzel M, Chang AL, Duggal A, Lanspa M, Herbert JT, Martinez A, Tonna J, Ammar MA, Nazer LH, Heavner M, Pender E, Chambers L, Kenes MT, Kaufman D, Downey A, Brown B, Chaykosky D, Wolff A, Smith M, Nault K, Gong MN, Sevransky JE, Lat I; Observation of VariatiOn in fLUids adMinistEred in shock-CHaracterizAtion of vaSoprEssor Requirements in Shock (VOLUME-CHASERS) Study Group and SCCM Discovery Network. Evaluation of Vasopressor Exposure and Mortality in Patients With Septic Shock. Crit Care Med. 2020 Oct;48(10):1445-1453.
Program Type:
Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study
Smischney NJ, Khanna AK, Brauer E, Morrow LE, Ofoma UR, Kaufman DA, Sen A, Venkata C, Morris P, Bansal V. Risk Factors for and Outcomes Associated With Peri-Intubation Hypoxemia: A Multicenter Prospective Cohort Study. J Intensive Care Med. 2020 Oct 1:885066620962445.
Program Type:
Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study
Smischney NJ, Kashyap R, Khanna AK, Brauer E, Morrow LE, Seisa MO, Schroeder DR, Diedrich DA, Montgomery A, Franco PM, Ofoma UR, Kaufman DA, Sen A, Callahan C, Venkata C, Demiralp G, Tedja R, Lee S, Geube M, Kumar SI, Morris P, Bansal V, Surani S; SCCM Discovery (Critical Care Research Network of Critical Care Medicine) HEMAIR Investigators Consortium. Risk factors for and prediction of post-intubation hypotension in critically ill adults: A multicenter prospective cohort study. PLoS One. 2020 Aug 31;15(8):e0233852.
Program Type:
Organizational Characteristics Associated With ICU Liberation (ABCDEF) Bundle Implementation by Adult ICUs in Michigan
Barr J, Ghaferi AA, Costa DK, et al. Organizational characteristics associated with ICU Liberation (ABCDEF) bundle implementation by adult ICUs in Michigan. Crit Care Explor. 2020 Aug 19;2(8):e0169. doi: 10.1097/cce.0000000000000169.
Program Type:
Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World
Kashyap R, Murthy S, Arteaga GM, Dong Y, Cooper L, Kovacevic T, Basavaraja C, Ren H, Qiao L, Zhang G, Sridharan K, Jin P, Wang T, Tuibeqa I, Kang A, Ravi MD, Ongun E, Gajic O, Tripathi S; SCCM Discovery CERTAINp Collaborative Investigators. Effectiveness of a Daily Rounding Checklist on Processes of Care and Outcomes in Diverse Pediatric Intensive Care Units Across the World. J Trop Pediatr. 2020 Aug 27:fmaa058.
Program Type:
Strategies to Optimize ICU Liberation (A to F) Bundle Performance in Critically Ill Adults With Coronavirus Disease 2019
Devlin JW, O'Neal HR Jr, Thomas C, et al. Strategies to optimize ICU liberation (A to F) bundle performance in critically ill adults with coronavirus disease 2019. Crit Care Explor. 2020 Jun 12;2(6):e0139. doi: 10.1097/cce.0000000000000139.
Program Type:
Physical Rehabilitation in Critically Ill Children: A Multicenter Point Prevalence Study in the United States
Kudchadkar SR, Nelliot A, Awojoodu R, et al; Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Physical rehabilitation in critically ill children: a multicenter point prevalence study in the United States. Crit Care Med. 2020 May;48(5):634-644. doi: 10.1097/CCM.0000000000004291.
Program Type:
The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness
Walkey AJ, Kumar VK, Harhay MO, Bolesta S, Bansal V, Gajic O, Kashyap R. The Viral Infection and Respiratory Illness Universal Study (VIRUS): An International Registry of Coronavirus 2019-Related Critical Illness. Crit Care Explor. 2020 Apr 29;2(4):e0113.
Program Type:
Best Practices for Conducting Interprofessional Team Rounds to Facilitate Performance of the ICU Liberation (ABCDEF) Bundle
Stollings JL, Devlin JW, Lin JC, Pun BT, Byrum D, Barr J. Best practices for conducting interprofessional team rounds to facilitate performance of the ICU Liberation (ABCDEF) bundle. Crit Care Med. 2020 Apr;48(4):562-570. doi: 10.1097/CCM.0000000000004197.
Program Type:
Association Between Hospital Mortality and Inspiratory Airway Pressures in Mechanically Ventilated Patients Without Acute Respiratory Distress Syndrome: A Prospective Cohort Study
Sahetya SK, Mallow C, Sevransky JE, et al; Society of Critical Care Medicine Discovery Network Critical Illness Outcomes Study Investigators. Association between hospital mortality and inspiratory airway pressures in mechanically ventilated patients without acute respiratory distress syndrome: a prospective cohort study. Crit Care. 2019 Nov 21;23(1):367. doi: 10.1186/s13054-019-2635-y.
Program Type:
Staged Implementation of Awakening and Breathing, Coordination, Delirium Monitoring and Management, and Early Mobilization Bundle Improves Patient Outcomes and Reduces Hospital Costs
Hsieh SJ, Otusanya O, Gershengorn HB, et al. Staged implementation of awakening and breathing, coordination, delirium monitoring and management, and early mobilization bundle improves patient outcomes and reduces hospital costs. Crit Care Med. 2019 Jul;47(7):885-893. doi: 10.1097/CCM.0000000000003765.
Program Type:
A Multicenter, Prospective, Observational Study to Determine Predictive Factors for Multidrug-Resistant Pneumonia in Critically Ill Adults: The DEFINE Study
Lat I, Daley MJ, Shewale A, et al; DEFINE study group; Discovery Research Network. A multicenter, prospective, observational study to determine predictive factors for multidrug-resistant pneumonia in critically ill adults: the DEFINE Study. Pharmacotherapy. 2019 Mar;39(3):253-260. doi: 10.1002/phar.2171.
Program Type:
Implementing the ABCDEF Bundle: Top 8 Questions Asked During the ICU Liberation ABCDEF Bundle Improvement Collaborative
Stollings JL, Devlin JW, Pun BT. Implementing the ABCDEF Bundle: top 8 questions asked during the ICU Liberation ABCDEF Bundle Improvement Collaborative. Crit Care Nurse. 2019 Feb;39(1):36-45. doi: 10.4037/ccn2019981.
Program Type:
Common Challenges to Effective ABCDEF Bundle Implementation: The ICU Liberation Campaign Experience
Balas MC, Pun BT, Pasero C, et al. Common challenges to effective ABCDEF bundle implementation: the ICU Liberation Campaign experience. Crit Care Nurse. 2019 Feb;39(1):46-60. doi:10.4037/ccn2019927.
Program Type:
Caring for Critically Ill Patients With the ABCDEF Bundle: Results of the ICU Liberation Collaborative in Over 15,000 Adults
Pun BT, Balas MC, Barnes-Daly MA, et al. Caring for critically ill patients with the ABCDEF Bundle: results of the ICU Liberation Collaborative in over 15,000 adults. Crit Care Med. 2019 Jan;47(1):3-14. doi: 10.1097/CCM.0000000000003482.
Program Type:
Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU
Devlin JW, Skrobik Y, Gélinas C, et al. Clinical practice guidelines for the prevention and management of pain, agitation/sedation, delirium, immobility, and sleep disruption in adult patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-e873. doi: 10.1097/CCM.0000000000003299.
Program Type:
Benzodiazepines and Development of Delirium in Critically Ill Children: Estimating the Causal Effect
Mody K, Kaur S, Mauer E, et al. Benzodiazepines and development of delirium in critically ill children: estimating the causal effect. Crit Care Med. 2018 Sep;46(9):1486-1491. doi: 10.1097/CCM.0000000000003194.
Program Type:
Current practices and safety of medication use during rapid sequence intubation: A multicenter study evaluating practices across the United States
Groth C, Acquisto NM, Khadem T. Current practices and safety of medication use during rapid sequence intubation: A multicenter study evaluating practices across the United States. J Crit Care 2018;45:65-70. Epub 2018 Jan 30.
Program Type:
Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients
Seethala RR, Hou PC, Aisiku IP, Frendl G, Park PK, Mikkelsen ME, Chang SY, Gajic O, Sevransky J. Early risk factors and the role of fluid administration in developing acute respiratory distress syndrome in septic patients. Ann Intensive Care. 2017 Dec;7(1):11.
Program Type:
Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome
Festic E, Carr GE, Cartin-Ceba R, Hinds RF, Banner-Goodspeed V, Bansal V, Asuni AT, Talmor D, Rajagopalan G, Frank RD, Gajic O, Matthay MA, Levitt JE. Randomized Clinical Trial of a Combination of an Inhaled Corticosteroid and Beta Agonist in Patients at Risk of Developing the Acute Respiratory Distress Syndrome. Crit Care Med. 2017 May;45(5):798-805.
Program Type:
Delirium and Mortality in Critically Ill Children: Epidemiology and Outcomes of Pediatric Delirium
Traube C, Silver G, Gerber LM, et al. Delirium and mortality in critically ill children: epidemiology and outcomes of pediatric delirium. Crit Care Med. 2017 May;45(6):891-898. doi: 10.1097/CCM.0000000000002324.
Program Type:
Delirium in Critically Ill Children: An International Point Prevalence Study
Traube C, Silver G, Reeder RW, et al. Delirium in critically ill children: an international point prevalence study. Crit Care Med. 2017 Apr;45(4):584-590. doi: 10.1097/CCM.0000000000002250.
Program Type:
Improving Hospital Survival and Reducing Brain Dysfunction at Seven California Community Hospitals: Implementing PAD Guidelines via the ABCDEF Bundle in 6,064 Patients
Barnes-Daly MA, Phillips G, Ely EW. Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF Bundle in 6,064 patients. Crit Care Med. 2017 Feb;45(2):171-178. doi: 10.1097/CCM.0000000000002149.
Program Type:
The ABCDEF Bundle: Science and Philosophy of how ICU Liberation Serves Patients and Families
Ely EW. The ABCDEF Bundle: science and philosophy of how ICU liberation serves patients and families. Crit Care Med. 2017 Feb;45(1):131-136. doi: 10.1097/CCM.0000000000002175.
Program Type:
Guidelines for Family-Centered Care in the Neonatal, Pediatric, and Adult ICU
Davidson JE, Aslakson RA, Long AC, et al. Guidelines for family-centered care in the neonatal, pediatric, and adult ICU. Crit Care Med. 2017 Jan;45(1):103-128. doi: 10.1097/CCM.0000000000002169.
Program Type:
Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals
Kadri SS, Miller AC, Hohmann S, Bonne S, Nielsen C, Wells C, Gruver C, Quraishi SA, Sun J, Cai R, Morris PE, Freeman BD, Holmes JH, Cairns BA, Suffredini AF. US Critical Illness and Injury Trials Group: Smoke Inhalation-associated Acute Lung Injury (SI-ALI) Investigators (USCIIT-SI-ALI) Risk Factors for In-Hospital Mortality in Smoke Inhalation-Associated Acute Lung Injury: Data From 68 United States Hospitals. Chest. 2016 Dec;150(6):1260-1268.
Program Type:
Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support
Barwise A, Garcia-Arguello L, Dong Y, Hulyalkar M, Vukoja M, Schultz MJ, Adhikari NK, Bonneton B, Kilickaya O, Kashyap R, Gajic O, Schmickl CN. Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN): Evolution of a content management system for point-of-care clinical decision support. BMC Med Inform Decis Mak. 2016 Oct 3;16(1):127.
Program Type:
Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A) Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14.
Program Type:
Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial
Kor DJ, Carter RE, Park PK, Festic E, Banner-Goodspeed VM, Hinds R, Talmor D, Gajic O, Ware LB, Gong MN; US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Effect of Aspirin on Development of ARDS in At-Risk Patients Presenting to the Emergency Department: The LIPS-A Randomized Clinical Trial. JAMA. 2016 Jun 14;315(22):2406-14.
Program Type:
A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States
Thomas Z, Bandali F, Sankaranarayanan J, Reardon T, Olsen K. A Multicenter Evaluation of Prolonged Empiric Antibiotic Therapy in Adult ICUs in the United States. Crit Care Med. 2015 Dec;43(12):2527-34.
Program Type:
Protocols and Hospital Mortality in Critically Ill Patients: The United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Sevransky JE, Checkley W, Herrera P, et al; United States Critical Illness and Injury Trials Group-Critical Illness Outcomes Study Investigators. Protocols and hospital mortality in critically ill patients: the United States Critical Illness and Injury Trials Group critical illness outcomes study. Crit Care Med. 2015 Oct;43(10):2076-2084. doi: 10.1097/CCM.0000000000001157.
Program Type:
SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk
Festic E, Bansal V, Kor DJ, Gajic O. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) SpO2/FiO2 ratio on hospital admission is an indicator of early acute respiratory distress syndrome development among patients at risk. J Intensive Care Med. 2015 May;30(4):209-16.
Program Type:
Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice
Vukoja M, Kashyap R, Gavrilovic S, Dong Y, Kilickaya O, Gajic O. Checklist for early recognition and treatment of acute illness: International collaboration to improve critical care practice. World J Crit Care Med. 2015 Feb 4;4(1):55-61.
Program Type:
Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU
Kane-Gill SL, LeBlanc JM, Dasta JF, Devabhakthuni S. Critical Care Pharmacotherapy Trials Network. A multicenter study of the point prevelance of drug-induced hypotension in the ICU. Crit Crit Care Med. 2014 Oct; 42(10):2197-2203.
Program Type:
CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries
Vukoja M, Riviello E, Gavrilovic S, Adhikari NK, Kashyap R, Bhagwanjee S, Gajic O, Kilickaya O. CERTAIN Investigators. A survey on critical care resources and practices in low- and middle-income countries. Glob Heart. 2014 Sep;9(3):337-42.e1-5
Program Type:
Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome
Karnatovskaia LV, Lee AS, Bender SP, Talmor D, Festic E. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) Obstructive sleep apnea, obesity, and the development of acute respiratory distress syndrome. J Clin Sleep Med. 2014 Jun 15;10(6):657-62.
Program Type:
Effectiveness and Safety of the Awakening and Breathing Coordination, Delirium Monitoring/Management, and Early Exercise/Mobility Bundle
Balas MC, Vasilevskis EE, Olsen KM, et al. Effectiveness and safety of the awakening and breathing coordination, delirium monitoring/management, and early exercise/mobility bundle. Crit Care Med. 2014 May;42(5):1024-1036. doi: 10.1097/CCM.0000000000000129.
Program Type:
Cornell Assessment of Pediatric Delirium: A Valid, Rapid, Observational Tool for Screening Delirium in the PICU
Traube C, Silver G, Kearney J, et al. Cornell Assessment of Pediatric Delirium: a valid, rapid, observational tool for screening delirium in the PICU. Crit Care Med. 2014 Mar;42(3):656-663. doi: 10.1097/CCM.0b013e3182a66b76.
Program Type:
Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study
Festic E, Bansal V, Gajic O, Lee AS. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Prehospital use of inhaled corticosteroids and point prevalence of pneumonia at the time of hospital admission: secondary analysis of a multicenter cohort study. Mayo Clin Proc. 2014 Feb;89(2):154-62.
Program Type:
Structure, Process, and Annual ICU Mortality Across 69 Centers: United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study
Checkley W, Martin GS, Brown SM, et al; United States Critical Illness and Injury Trials Group Critical Illness Outcomes Study Investigators. Structure, process, and annual ICU mortality across 69 centers: United States Critical Illness and Injury Trials Group Critical Illness outcomes study. Crit Care Med. 2014 Feb;42(2):344-56. doi: 10.1097/CCM.0b013e3182a275d7.
Program Type:
Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk
Festic E, Ortiz-Diaz E, Lee A, Li G, Kor DJ, Adebola A, Akca O, Hoth J, Levitt JE, Carter R, Gajic O. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Prehospital use of inhaled steroids and incidence of acute lung injury among patients at risk. J Crit Care. 2013 Dec;28(6):985-91.
Program Type:
The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes
Karnatovskaia LV, Lee AS, Gajic O, Festic E. U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS) The influence of prehospital systemic corticosteroid use on development of acute respiratory distress syndrome and hospital outcomes. Crit Care Med. 2013 Jul;41(7):1679-85.
Program Type:
Research Recruitment Practices and Critically Ill Patients. A Multicenter, Cross-Sectional Study (The Consent Study)
Burns KE, Zubrinich C, Tan W, et al; Canadian Critical Care Trials Group. Research recruitment practices and critically ill patients. A multicenter, cross-sectional study (the Consent Study). Am J Respir Crit Care Med. 2013 Jun 1;187(11):1212-1218. doi: 10.1164/rccm.201208-1537OC.
Program Type:
Sex, race, and the development of acute lung injury
Lemos-Filho LB, Mikkelsen ME, Martin GS, Dabbagh O, Adesanya A, Gentile N, Esper A, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Sex, race, and the development of acute lung injury. Chest. 2013 Apr;143(4):901-909.
Program Type:
Contemporary ventilator management in patients with and at risk of ALI/ARDS
Chang SY, Dabbagh O, Gajic O, Patrawalla A, Elie MC, Talmor DS, Malhotra A, Adesanya A, Anderson HL 3rd, Blum JM, Park PK, Gong MN. United States Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS) Contemporary ventilator management in patients with and at risk of ALI/ARDS. Respir Care. 2013 Apr;58(4):578-88.
Program Type:
United States Critical Illness and Injury Trials Group
Blum JM, Morris PE, Martin GS, Gong MN, Bhagwanjee S, Cairns CB, Cobb JP. United States Critical Illness and Injury Trials Group. Chest. 2013 Mar;143(3):808-813.
Program Type:
Clinical Practice Guidelines for the Management of Pain, Agitation, and Delirium in Adult Patients in the Intensive Care Unit
Barr J, Fraser GL, Puntillo K, et al; American College of Critical Care Medicine. Clinical practice guidelines for the management of pain, agitation, and delirium in adult patients in the intensive care unit. Crit Care Med. 2013 Jan;41(1):263-306. doi: 10.1097/CCM.0b013e3182783b72.
Program Type:
Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk
Karnatovskaia LV, Festic E, Gajic O, Carter RE, Lee AS. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Preshospital amiodarone may increase the incidence of acute respiratory distress syndrome among patients at risk. J Crit Care. 2012 Oct;27(5):447-53.
Program Type:
Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation
Gill KV, Voils SA, Chenault GA, Brophy GM. Perceived versus actual sedation practices in adult intensive care unit patients receiving mechanical ventilation. Ann Pharmacother. 2012 Oct; 46 (10): 1331-9.
Program Type:
Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury
Kor DJ, Talmor DS, Banner-Goodspeed VM, Carter RE, Hinds R, Park PK, Gajic O, Gong MN. US Critical Illness and Injury Trials Group: Lung Injury Prevention with Aspirin Study Group (USCIITG: LIPS-A). Lung Injury Prevention with Aspirin (LIPS-A): A protocol for a multicenter randomised clinical trial in medical patients at high risk of acute lung injury. BMJ Open. 2012 Sep 4;2(5).
Program Type:
Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk
Elie-Turenne MC, Hou PC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1.) Lung injury prediction score for the emergency department: first steps towards prevention in patients at risk. Int J Emerg Med. 2012 Sep 3;5(1):33
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Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations
Deutschman CS, Ahrens T, Cairns CB, Sessler CN, Parsons PE. Critical Care Societies Collaborative, USCIITG Task Force on Critical Care Research. Multisociety Task Force for Critical Care Research: Key issues and recommendations. Crit Care Med. 2012 Jan;40
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Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units
Ali NA, Gutteridge D, Shahul S, Checkley W, Sevransky J, Martin GS. Critical Illness Outcomes Study: An Observational Study on Protocols and Mortality in Intensive Care Units. J Clin Trials. 2011 Sep 23;2011(3):55-65.
Program Type:
Critical Illness Outcome Study: An Observational Study on Protocols and Mortality in Intensive Care Units
Ali NA, Gutteridge D, Shahul S, Checkley W, Sevransky J, Martin GS. Critical illness outcome study: an observational study on protocols and mortality in intensive care units. Open Access J Clin Trials. 2011 Sep 23;2011(3):55-65. doi: 10.2147/OAJCT.S24223.
Program Type:
Early identification of patients at risk of acute lung injury: Evaluation of lung injury prediction score in a multicenter cohort study
Gajic O, Dabbagh O, Park PK, Adesanya A, Chang SY, Hou P, Anderson H 3rd, Hoth JJ, Mikkelsen ME, Gentile NT, Gong MN, Talmor D, Bajwa E, Watkins TR, Festic E, Yilmaz M, Iscimen R, Kaufman DA, Esper AM, Sadikot R, Douglas I, Sevransky J, Malinchoc M . U.S. Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG-LIPS). Early identification of patients at risk of acute lung injury: evaluation of lung injury prediction score in a multicenter cohort study. Am J Respir Crit Care Med. 2011 Feb 15;183(4):462-70.
Program Type:
Off-label medication use in adult critical care patients
Lat I, Micek S, Janzen J, Cohen H, Olsen K, Haas C. Off-label medication use in adult critical care patients. J Crit Care. 2011 Feb; 26(1): 89-94.
Program Type:
The United States critical illness and injury trials group: An introduction
Cobb JP, Cairns CB, Bulger E, Wong HR, Parsons PE, Angus DC, Gentile NT, Hoyt DB, Schwinn DA, Wiener-Kronish JP, Upperman JS. The United States critical illness and injury trials group: an introduction. J Trauma. 2009 Aug;67(2 Suppl):S159-60.
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Towards prevention of acute lung injury: Frequency and outcomes of emergency department patients at-risk – a multicenter cohort study
Hou PC, Elie-Turenne MC, Mitani A, Barry JM, Kao EY, Cohen JE, Frendl G, Gajic O, Gentile NT. US Critical Illness and Injury Trials Group: Lung Injury Prevention Study Investigators (USCIITG–LIPS 1). Towards prevention of acute lung injury: frequency and outcomes of emergency department patients at-risk – a multicenter cohort study. Int J Emerg Med. 2012 May 27;5(1):22.
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