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A global COVID-19 registry that tracks ICU and hospital care patterns in near real time
Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. There is no intervention or patient interaction. Only de-identified data are used for analysis.
ClinicalTrials.gov Identifier: NCT04323787
Please check whether your site is already enrolled as a VIRUS participating site before enrolling. Then complete the intake form and download the frequently asked questions.
 | Check the VIRUS Participation List |
 | Complete the Intake Form to Participate |
 | Download VIRUS FAQs |
The registry will be essential for near-real-time observational comparative effectiveness studies to determine effective treatment strategies and/or provide meaningful hypotheses for clinical trials.
A waiver of informed consent for data collection is being requested for this study from participating sites. No patients will be contacted, but clinicians participating in the study will be surveyed for feedback and satisfaction. For any questions, contact Vishakha Kumar.
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Press releases and news articles highlighting VIRUS activities.
Biomarker-Concordant Steroid Administration in Severe Coronavirus Disease-2019
Tekin A, Domecq JP, Morales DJV, et al; Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. J Intensive Care Med. 2023 Nov;38(11):1003-1014. doi: 10.1177/08850666231177200. Epub 2023 May 24.PMID: 37226483
Program Type:
The Association of Early Systemic Corticosteroids and Secondary Infection Amongst Hospitalized COVID-19 Patients: Results from the SCCM Discovery Virus COVID-19 Registry
Bansal VB, Jain NK, Lal A, Domecq JP, Tekin A, Mir M, Attallah JN, Hassan E, Ahmed H, Anwar M, Khedr A, Kumar V, Robinson S, Kondori MJ, Koritala T, Boman K, Cartin-Ceba R, Christie A, Armaignac D, La Nou A, Sanghavi D, Walkey AJ, Kashyap R, Khan SA. The Association of Early Systemic Corticosteroids and Secondary Infection Amongst Hospitalized COVID-19 Patients: Results from the SCCM Discovery Virus COVID-19 Registry. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
Program Type:
Impact of Early Tracheostomy on Hospitalization Outcomes in Mechanically Ventilated COVID-19 Patients
Isha S, Khadka S, Shrestha R, Satashia P, Balasubramanian P, Jenkins A, Hanson A, Singh K, Jena A, Tekin A, Bansal V, Kashyap R, Balavenkataraman A, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Impact of Early Tracheostomy on Hospitalization Outcomes in Mechanically Ventilated COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
Program Type:
Early Tracheostomy is Associated with Improved Mobility and Shorter Duration of Sedative-Analgesic Use in Critically Ill COVID-19 Patients
Satashia P, Isha S, Shrestha R, Khadka S, Balasubramanian P, Singh K, Jena A, Jenkins A, Hanson A, Tekin A, Bansal V, Kashyap R, Balavenkataraman A, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Shapiro AB, Chaudhary S, Bhattacharyya A, Guru PK, Moreno Franco P, Sanghavi D. Early Tracheostomy Is Associated With Improved Mobility and Shorter Duration of Sedative-Analgesic Use in Critically Ill COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
Program Type:
Incidence of Post-Intubation Complications in Early vs Late-Tracheostomy in Hospitalized COVID-19 Patients
Khadka S, Isha S, Shrestha R, Satashia P, Balasubramanian P, Hanson A, Jenkins A, Jena A, Singh K, Balavenkataraman A, Tekin A, Bansal V, Kashyap R, Khan SA, Diaz Milian R, Patel NM, Quinones Q, Kiley S, Bhattacharyya A, Shapiro AB, Chaudhary S, Guru PK, Moreno Franco P, Sanghavi D. Incidence of Post-Intubation Complications in Early vs Late-Tracheostomy in Hospitalized COVID-19 Patients. Abstract presented at CHEST 2023; October 8-11, 2023. CHEST. 2023;164(4):A1755-A1756. doi:10.1001/chest.2023.164.4_MeetingAbstracts.A1755-A1756
Program Type:
Mayo Clinic
Rochester, Minnesota, USA
Boston University
Boston, Massachusetts, USA
Mayo Clinic Foundation
Rochester, Minnesota, USA
Discovery, the Critical Care Research Network
Society of Critical Care Medicine
Submission process: Ancillary study proposals may be submitted for a subset of de-identified data for research purposes by investigators of participating sites in the VIRUS study. Proposals are submitted via an online submission portal. Submitted proposals are reviewed by the Discovery VIRUS Publication Review Workgroup for approval and feedback.
Datasets may be made available to outside groups (nonparticipating sites and investigators) after initial publication of the data by study principal investigators within 12 months of study conclusion. A Data Use Agreement must be in place for this type of request.
Review Process: The Discovery VIRUS Publication Review Workgroup will assign two to three reviewers per proposal. The timeline for approval is up to 30 days.
The proposal submission portal is now open. Access the submission portal.
Feedback on proposals will be shared with investigators. The Discovery VIRUS Publication Review Workgroup makes rapid review of proposals a priority. Once approved, investigators receive access to the de-identified subset of data from the VIRUS dataset.
