SCCM is updating its SCCM Connect Community. Access to SCCM Connect may be limited until April 23.

Discovery VIRUS COVID-19 Registry

A global COVID-19 registry that tracks ICU and hospital care patterns in near real time

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Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. There is no intervention or patient interaction. Only de-identified data are used for analysis.

ClinicalTrials.gov Identifier: NCT04323787

VIRUS COVID-19 Registry Dashboard

 

SCCM




 
                  

VIRUS COVID-19 Registry Enrollment

Please check whether your site is already enrolled as a VIRUS participating site before enrolling. Then complete the intake form and download the frequently asked questions.

Check the VIRUS Participation List
Complete the Intake Form to Participate
Download VIRUS FAQs
 

Inclusion Criteria

  • COVID-19 PCR (or other SARS-CoV-2) test positive within 21 days
  • COVID-19 PCR pending
  • COVID-19 high clinical suspicion

Primary Aims

  • Create a real-time COVID-19 registry of current intensive care unit and hospital care patterns to allow evaluation of safety and observational effectiveness of COVID-19 practices
  • Determine practice variations across hospitals

Hypothesis

The registry will be essential for near-real-time observational comparative effectiveness studies to determine effective treatment strategies and/or provide meaningful hypotheses for clinical trials.


Institutional Review Board: Waiver of Consent

A waiver of informed consent for data collection is being requested for this study from participating sites. No patients will be contacted, but clinicians participating in the study will be surveyed for feedback and satisfaction. For any questions, contact Vishakha Kumar.
 

Join the SCCM Connect Discovery Group

Approved sites with IRB approval can join the SCCM Connect Discovery Group. Access includes a discussion board and the ability to connect with other Discovery participants.

This is the best way to get regular updates about VIRUS!

Request to join the Discovery SCCM Connect Group
 

STOP-VIRUS ICU Learning Collaborative

ICUs participating in the VIRUS Registry may also be among the 20 sites participating in the STOP-VIRUS collaborative. For more information about this network of ICUs, its leaders and participants, and the learning material being developed, click here.


Recent Publications

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic
Cervantes-Arslanian AM, Venkata C, Anand P, Burns JD, Ong CJ, LeMahieu AM, Schulte PJ, Singh TD, Rabinstein AA, Deo N, Bansal V, Boman K, Domecq Garces JP, Lee Armaignac D, Christie AB, Melamed RR, Tarabichi Y, Cheruku SR, Khanna AK, Denson JL, Banner-Goodspeed VM, Anderson HL 3rd, Gajic O, Kumar VK, Walkey A, Kashyap R. Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic. Crit Care Explor. 2022 Apr 25;4(4):e0686. doi: 10.1097/CCE.0000000000000686. PMID: 35492258; PMCID: PMC9042584.
Program Type: VIRUS

Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database
Turek JR, Bansal V, Tekin A, Singh S, Deo N, Sharma M, Bogojevic M, Qamar S, Singh R, Kumar V, Kashyap R. Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database. JMIR Res Protoc. 2022 Mar 15;11(3):e27921. doi: 10.2196/27921.
Program Type: VIRUS

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry
Tekin A, Qamar S, Singh R, Bansal V, Sharma M, LeMahieu AM, Hanson AC, Schulte PJ, Bogojevic M, Deo N, Zec S, Valencia Morales DJ, Belden KA, Heavner SF, Kaufman M, Cheruku S, Danesh VC, Banner-Goodspeed VM, St Hill CA, Christie AB, Khan SA, Retford L, Boman K, Kumar VK, O'Horo JC, Domecq JP, Walkey AJ, Gajic O, Kashyap R, Surani S; Society of Critical Care Medicine (SCCM) Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry. World J Crit Care Med. 2022 Mar 9;11(2):102-111. doi: 10.5492/wjccm.v11.i2.102. PMID: 35433315; PMCID: PMC8968480.
Program Type: VIRUS

Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry
Deo N, Tekin A, Bansal V, Koritala T, Mullen B, Armaignac DL, Chiotos K, Bjornstad EC, Gharpure VP, Bogojevic M, Qamar S, Singh R, Sharma M, Gajic O, Kumar V, Walkey A, Kashyap R, Domecq JP, Alavi A; From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID-19 Registry Investigator Group. Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry. Int J Dermatol. 2022 May;61(5):623-625. doi: 10.1111/ijd.16134. Epub 2022 Feb 19. PMID: 35182396.
Program Type: VIRUS

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19
Johnson SW, Garcia MA, Sisson EKQ, Sheldrick CR, Kumar VK, Boman K, Bolesta S, Bansal V, Lal A, Domecq JP, Melamed RR, Christie AB, Husain A, Yus S, Gajic O, Kashyap R, Walkey AJ. Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19. Crit Care Explor. 2022 Feb 18;10(2):e0638. doi: 10.1097/CCE.0000000000000638.
Program Type: VIRUS

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VIRUS Investigators 

Discovery, the Critical Care Research Network, is leading the efforts for this global COVID-19 registry. 
Rahul Kashyap, MBA, MD
VIRUS Principal Investigator
Rahul Kashyap, MBA, MD

HCA Healthcare
Nashville, Tennessee, USA
Mayo Clinic
Rochester, Minnesota, USA

Allan J. Walkey, MD, MSc
VIRUS Co-Principal Investigator
Allan J. Walkey, MD, MSc

Boston University
Boston, Massachusettes, USA

Juan Pablo Domecq Garces, MD
VIRUS Co-Principal Investigator
Juan Pablo Domecq Garces, MD

Mayo Clinic Foundation
Rochester, Minnesota, USA

Vishakha Kumar, MD, MBA
VIRUS Co-Principal Investigator
Vishakha Kumar, MD, MBA

Discovery, the Critical Care Research Network
Society of Critical Care Medicine


VIRUS Ancillary Studies

Ancillary study proposals may be submitted for a subset of de-identified data for research purposes by investigators of participating sites in the VIRUS study. 

The proposal submission period is now closed.
 

Information for Investigators

  • Any conflict of interest with the ancillary study proposal will be disclosed by the reviewers and the investigators.
  • The ancillary study proposals have been kept blinded from the VIRUS core investigator group. The first batch of ancillary proposals will be published once the review period closes and notifications are sent to the investigators.
  • SCCM, including the VIRUS core investigators group, has the first right upon publication of the dataset for the research hypothesis outlined for the VIRUS Study.
  • Study participants can serve on the writing group with the VIRUS core investigators team, if their ancillary study ideas overlap or align with the VIRUS overall project aims.
  • Collaboration (national and international) on ancillary proposal submissions is encouraged.
  • Ancillary proposal approval and data sharing will also depend on data quality and completion of the investigator’s own site data for the VIRUS study.

Ancillary Study Approval Process

Manuscript Approval Process