Reducing Mortality From Sepsis in Low-Resource Settings

Expanding sepsis care worldwide.

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The Society of Critical Care Medicine (SCCM) has received funding for a multiphase project dedicated to reducing mortality from sepsis in low-resource settings.

Phase 1 of this project is now complete and focused on better understanding the needs of clinicians in low-resource settings through surveys, focus groups, and a literature review of available evidence.

Key Milestones

  • The project team convened an Utstein Conference in October 2024 in Geneva, Switzerland, to align expert consensus on sepsis care priorities.
  • The “Sepsis Chain of Survival” concept was developed and published in Critical Care Medicine and underscores the importance of early recognition of sepsis, optimized critical care management, and comprehensive post-sepsis care.
  • A task force representing multidisciplinary care developed a 10-steps framework that provides a consensus-driven roadmap to improve sepsis care, strengthen the sepsis chain of survival, and address global inequities in sepsis outcomes.
  • Two pilot workshops in Kenya and Belize tested the 10-steps framework in practice and identified gaps in sepsis recognition pathways.

Looking Ahead to Phase 2

Saving Lives From Sepsis: From Evidence to Impact
Building on the success of Phase 1 of this project, SCCM and the Global Sepsis Alliance (GSA), in collaboration with the World Health Organization (WHO), have secured a new grant from the Laerdal Foundation to launch the project “Saving Lives From Sepsis: From Evidence to Impact.” Phase 2 will expand implementation of the 10-steps framework from the two pilot sites to 10 countries across all WHO regions, while also advancing a global sepsis research strategy and a first-of-its-kind WHO report on health system responses to sepsis.

Funding

This project is funded through the Laerdal Foundation. Phase 1 and the initial pilot phase were completed in 2026. Phase 2 is currently underway and is supported by a new grant, in partnership with the GSA and WHO.

About the Laerdal Foundation
The Laerdal Foundation was established to provide financial support to practically oriented research projects that can help prevent needless deaths due to sudden cardiac arrest, from trauma, or during birth. The foundation particularly prioritizes applications in the focus areas defined in its strategy and considered to have a high potential to improve patient outcomes.

News 

Project Leaders

Jorge L. Hidalgo, MD, MACP, FCCP, MCCM

Jorge L. Hidalgo, MD, MACP, FCCP, MCCM

Samuel Akech, MBChB, MMED, PhD

Samuel Akech, MBChB, MMED, PhD

Niranjan Kissoon, MD, MCCM

Niranjan Kissoon, MD, MCCM

Vinay M. Nadkarni, MD, MS, FCCM

Vinay M. Nadkarni, MD, MS, FCCM

Ryan C. Maves, MD, FCCM

Ryan C. Maves, MD, FCCM

Brenda M. Morrow, PhD

Brenda M. Morrow, PhD

SCCM Staff

  • Vishakha Kumar, MD, MBA, Director of Research and Quality
  • Hariyali Patel, MHA, Program Manager
  • Dan Woznica, PhD, Implementation Scientist
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