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Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation

From Critical Care Explorations

The authors present a case series of eleven patients, five treated with camostat mesylate and six treated with hydroxychloroquine.


SCCM Pod-353 Are Biomarkers Ready for Prime Time?

Kyle Enfield, MD, speaks with John A. Kellum, MD, MCCM, about his talk presented at the 46th Critical Care Congress in Honolulu, Hawaii entitled, “Are Biomarkers Ready for Prime Time?” Dr. Kellum works as an Intensivist in the Cardiothoracic ICU at the University of Pittsburgh Medical Center (UPMC) in Pittsburgh, Pennsylvania. He is also the Vice Chair for Research and Director of the Center for Critical Care Nephrology in the Department of Critical Care Medicine at UPMC. He discusses how the understanding of acute kidney injury (AKI) has evolved and which biomarkers are most effective in identifying risk of AKI. Released: 11/9/17


REDISCOVER-ICU: Utilizing Data to Study Drug Repurposing Beyond COVID-19

The COVID-19 pandemic exposed significant gaps in the healthcare system, such as healthcare inequities and the need for more treatment options for intensive care unit patients with serious illnesses. Looking beyond COVID-19 to sepsis and other critical care illnesses, the Society of Critical Care Medicine and Critical Path Institute’s CURE Drug Repurposing Collaboratory are collaborating on the new study Repurposing Drugs in Intensive Care Units Through Real-World Data Analysis (REDISCOVER-ICU).


SCCM Pod-413 COVID-19 Fact Versus Science Fiction

Explore the need for randomized COVID-19 clinical trials and the difficulties and potential consequences of misinformation (Ingraham N, et al. Crit Care Explor. 2020;2:e0108) with host Ashish K. Khanna, MD, FCCP, FCCM, and Nicholas E. Ingraham, MD.


SCCM Pod-414 COVID-19 VIRUS Registry Aims to Identify Effective Treatment Strategies

Discovery, the Critical Care Research Network's Viral Infection and Respiratory Illness Universal Study creates a real-time COVID-19 registry of current ICU and hospital care patterns.


Letter to the Editor: Factors Associated With Pulmonary Embolism Among Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

From Critical Care Explorations. To do better understand the risk factors associated with pulmonary embolism in patients with COVID-19, the authors performed a post hoc analysis from the COVADIS project, a multicenter observational study gathering 21 ICUs from France and Belgium.


Evaluation of the Risk Prediction Tools for Patients With Coronavirus Disease 2019 in Wuhan, China: A Single-Centered, Retrospective, Observational Study

From Critical Care Medicine. In this study from China, the authors evaluated and compared the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019.


Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry

From Critical Care Medicine. In this article, the authors describe how the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study coronavirus disease 2019 registry sought to develop and implement prespecified best practices combined with grassroots efforts from clinical sites worldwide in order to develop clinically useful knowledge in response to a pandemic.
 


A Propensity-Matched Cohort Study of Tocilizumab in Patients With Coronavirus Disease 2019

From Critical Care Explorations

The authors assessed the impact of tocilizumab therapy and found that it was associated with significantly improved survival in coronavirus disease 2019 patients.


CDC Resources: Research

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Research


Big Data Leads to the Discovery Data Science Campaign

The Discovery Data Science Campaign was launched in 2022 to improve the care of critically ill patients by leveraging the use of large-scale data (big data) for research. The campaign’s goal is to apply findings from data analysis in a clinical environment through standardized data models and shared resources, starting with the 2023 Datathon.


SCCM Pod-477: Going Viral With the Discovery VIRUS COVID-19 Registry

The Viral Infection and Respiratory Illness Universal Study (VIRUS) is a prospective, cross-sectional, observational study and registry of all eligible adult and pediatric patients who are admitted to a hospital. Marilyn N. Bulloch, PharmD, BCPS, FCCM, was joined by Rahul Kashyap, MD, MBA, at the 2023 Critical Care Congress to discuss the Discovery VIRUS COVID-19 Registry. Dr. Kashyap is an assistant professor and clinical research scientist at Mayo Clinic in Rochester, Minnesota, USA.


SCCM Pod-489: The AIMS Trial: Battle of the Bundles, Hour-1 Versus 3-Hour

The Assessment of Implementation of Methods in Sepsis and Respiratory Failure (AIMS) Study seeks to determine the safest and most effective approach to sepsis intervention using the evidence-based Surviving Sepsis Campaign guidelines. Marilyn N. Bulloch, PharmD, BCPS, FCCM, was joined by Mitchell M. Levy, MD, MCCM, at the 2023 Critical Care Congress to discuss the goal of the AIMS Study and the elements of both the Hour-1 and 3-Hour bundles. Dr. Levy is chief of the Division of Critical Care, Pulmonary, and Sleep Medicine and professor of medicine at the Warren Alpert Medical School of Brown University. He is also the medical director of the medical ICU at Rhode Island Hospital in Providence, Rhode Island, USA.


World-Renowned Experts at the 2024 Critical Care Congress

SCCM is thrilled to bring world-renowned thought leaders to the 2024 Critical Care Congress to discuss innovative developments and hot topics in critical care. Read the thought leaders’ own previews of their upcoming sessions!