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Discovery Activities

Explore Discovery's endorsed projects and published works.

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Discovery provides many opportunities for clinical investigators, including submission and presentation of new clinical proposals. Once reviewed and presented, these proposals can become endorsed projects or Discovery programs. The criteria for proposals and lists of current endorsed projects and Discovery programs are listed below.

Severe Acute Respiratory Infection – Preparedness

Severe Acute Respiratory Infection – Preparedness (SARI-PREP) is a multicenter consortium funded by the National Foundation for the Centers for Disease Control and Prevention, assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches.

Viral Infection and Respiratory Illness Universal Study COVID-19 Registry

The Viral Infection and Respiratory Illness Universal Study (VIRUS) COVID-19 is registry of current hospital care patterns to allow evaluations of safety and observational effectiveness of COVID-19 practices and to determine the variations in practice across hospitals.

Assessment of Implementation Methods in Sepsis and Respiratory Failure

Assessment of Implementation Methods in Sepsis and Respiratory Failure (AIMS) seeks to determine the safest and most effective approach to sepsis intervention using the Surviving Sepsis Campaign guidelines. The study is funded by a grant from the National Heart, Lung, and Blood Institute.

STOP-Trauma ICU Learning Collaborative

Structured Team-based OPtimal critical care for Trauma victims (STOP-Trauma) comprises a network of Ukrainian intensivists and international experts in wartime trauma experience who use their knowledge to support one another in treating Ukrainian civilians impacted by war.

Current Discovery Programs 

Discovery Programs are initiatives or groups of projects that have matured to the point of requiring their own organizational structure within the Discovery portfolio of programs. Programs usually have substantial, peer-reviewed funding. Because of their size and complexity, they have their own program publication oversight committees. Program leaders may attend and participate in Discovery Steering Committee meetings in an ad hoc manner as appropriate.

Programs for Emergency Preparedness (PREP)

Prevention of Organ Failure (PROOF)

Critical Illness Outcomes Study (CIOS)

Practices Surrounding the Identification, Prevention, and Treatment of Delirium in the ICU


A Multicenter Study to Evaluate Predictive Factors for Multidrug-Resistant Healthcare-Associated Pneumonia in Critically Ill Patients (DEFINE)

Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN)



Endorsed Projects 

Endorsed projects are active research projects that are endorsed by the Discovery Steering Committee. The highest-ranked proposals from Discovery clinical investigators meetings become endorsed projects. On request, endorsed projects will receive an endorsement letter on behalf of the Discovery Steering Committee. Projects must remain active and provide periodic updates to the Discovery Steering Committee.

Vitamin C, Corticosteroids, and Thiamine in Sepsis Study (VICTAS) 

Severe ARDS: Generating Evidence (SAGE)

Structure, Process, and Utilization of Intermediate Care in the United States


Early After TBI Study: Opposing Sympathetic Drive Early After Traumatic Brain Injury - Phase 3 (OSD-3)

Monitoring EEG in Comatose ICU Patients: A Point Prevalence Observational Study of Intensive Care Unit Experiences (MECIP)

Titration of Inspired Oxygen During Mechanical Ventilation Using Electronic Alerts via Electronic Health Records: A Multicenter Study


VOLUME-CHASERS: Observation of Variation in Fluids Administered and Characterization of Vasopressor Requirements in Shock

Inhaled Versus Early Systemic Steroids for Treatment of Pneumonia (INVESST Pneumonia)

High-Flow Oxygen Versus Positive Pressure Ventilation in the Emergency Department Program (USCIIT-HOPE)

Recovery From Acute Kidney Injury Requiring Dialysis: Incidence, Timeline, and Risk Prediction Models


Oral Midodrine Hydrochloride in Early Sepsis: Randomized, Double-Blind, and Placebo-Controlled Feasibility Study

Worldwide Assessment of Separation of Patients From Ventilatory Assistance (WEAN SAFE)

Development and Implementation of Clinical Prediction Models for Seizures During Post-Cardiac Arrest Care

Relationship Between Implementation of Evidence-Based and Supportive ICU Care and Outcomes of Patients With Acute Respiratory Distress Syndrome (ICU-LIBERATION Study)

Multicenter Assessment of Practices After In-Hospital Cardiac Arrest (DISCOVER-IHCA)


Recent Publications