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Discovery Activities

Explore Discovery's endorsed projects and published works.

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Discovery provides many opportunities for clinical investigators, including submission and presentation of new clinical proposals. Once reviewed and presented, these proposals can become Endorsed Projects or Discovery Programs. Please find the criteria for proposals and lists of current endorsed projects and Discovery programs below

Severe Acute Respiratory Infection - Preparedness

SARI-PREP is a multicenter consortium funded by the National Foundation for the Centers for Disease Control and Prevention. It is being assembled with the goal of providing the infrastructure to rapidly collect prospective data on clinical risks and outcomes, hospital-level stress, and biologic specimens that will aid in the rapid development of diagnostic and treatment approaches.

Viral Infection and Respiratory Illness Universal Study COVID-19 Registry

The Viral Infection and Respiratory Illness Universal Study (VIRUS) COVID-19 is registry of current hospital care patterns to allow evaluations of safety and observational effectiveness of COVID-19 practices and to determine the variations in practice across hospitals.

Current Discovery Programs 

Discovery Programs are initiatives or groups of projects that have matured programmatically to the point of requiring their own organizational structure within the Discovery portfolio of programs. Programs usually have substantial, peer-reviewed funding and, because of their size and complexity, have their own program publication oversight committees. Program leaders may attend and participate in Discovery Steering Committee meetings, in an ad hoc manner as appropriate.

Programs for Emergency Preparedness (PREP)

Prevention of Organ Failure (PROOF)

Critical Illness Outcomes Study (CIOS)

Practices Surrounding the Identification, Prevention, and Treatment of Delirium in the ICU


A Multicenter Study to Evaluate Predictive Factors for Multidrug-Resistant Healthcare-Associated Pneumonia in Critically Ill Patients (DEFINE)

Checklist for Early Recognition and Treatment of Acute Illness and Injury (CERTAIN)


Endorsed Projects 

Active research projects and endorsed by the Discovery Steering Committee. The highest ranked proposals from Discovery Clinical Investigator meetings become Endorsed Projects. Projects are endorsed by the Discovery Steering Committee and upon request will receive an endorsement letter on behalf of the SCCM Discovery Steering Committee. Projects must remain active and provide periodic updates to the SCCM Discovery Steering Committee.

Vitamin C, Corticosteroids, and Thiamine in Sepsis Study (VICTAS) 

Severe ARDS: Generating Evidence (SAGE)

Structure, Process, and Utilization of Intermediate Care in the United States


Early After TBI Study: Opposing Sympathetic Drive Early After Traumatic Brain Injury - Phase 3 (OSD-3)

Monitoring EEG in Comatose ICU Patients: A Point Prevalence Observational Study of Intensive Care Unit Experiences (MECIP)

Titration of Inspired Oxygen During Mechanical Ventilation Using Electronic Alerts via Electronic Health Records: A Multicenter Study


VOLUME-CHASERS: Observation of Variation in Fluids Administered and Characterization of Vasopressor Requirements in Shock

Inhaled Versus Early Systemic Steroids for Treatment of Pneumonia (INVESST Pneumonia)

High-Flow Oxygen Versus Positive Pressure Ventilation in the Emergency Department Program (USCIIT-HOPE)

Recovery From Acute Kidney Injury Requiring Dialysis: Incidence, Timeline, and Risk Prediction Models


Oral Midodrine Hydrochloride in Early Sepsis: Randomized, Double-Blind, and Placebo-Controlled Feasibility Study

Worldwide Assessment of Separation of Patients From Ventilatory Assistance (WEAN SAFE)

Development and Implementation of Clinical Prediction Models for Seizures During Post-Cardiac Arrest Care

Recent Publications

Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic

Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

Cutaneous manifestations of hospitalized COVID-19 patients in the VIRUS COVID-19 registry

Hospital Variation in Management and Outcomes of Acute Respiratory Distress Syndrome Due to COVID-19

Association of hypothyroidism with outcomes in hospitalized adults with COVID‐19: Results from the International SCCM Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS): COVID‐19 Registry in Clinical Endocrinology

Palliative care consultation and end-of-life outcomes in hospitalized COVID-19 patients

Metabolic Syndrome and Acute Respiratory Distress Syndrome in Hospitalized Patients With COVID-19

Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group

Clinical characteristics and outcomes of critically ill mechanically ventilated COVID-19 patients receiving interleukin-6 receptor antagonists and corticosteroid therapy: a preliminary report from a multinational registry

View All Discovery Articles