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Tag: Clinical Trials

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Coronavirus Disease 2019 Temperature Trajectories Correlate With Hyperinflammatory and Hypercoagulable Subphenotypes

From Critical Care Medicine The authors determined the association between temperature trajectories and distinct manifestations of coronavirus disease 2019.

Letter to the Editor: Bias Due to Cohort Construction in the Study of Timing of Invasive Ventilation

From Critical Care Explorations. In this Letter to the Editor, the authors respond to an article by Dupuis et al., congratulating the contribution to the problem of identifying which patients with hypoxemic respiratory failure truly benefit from invasive ventilation and suggesting future studies of invasive ventilation consider using the target trial concept in order to minimize bias and maximize the clinical applicability of results.

Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery

From Critical Care Medicine. The authors sought to establish the core outcome measures for respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality for trials in coronavirus disease 2019.

Intravenous Immunoglobulin Plus Methylprednisolone Mitigate Respiratory Morbidity in Coronavirus Disease 2019

From Critical Care Explorations

The authors piloted a randomized trial of IV immunoglobulin in coronavirus disease 2019 patients and found significantly improved hypoxia and reduced hospital length of stay.

Core Outcomes Set for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The authors aimed to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019.

International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The author set out to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 trials.

SCCM Pod-414 COVID-19 VIRUS Registry Aims to Identify Effective Treatment Strategies

Discovery, the Critical Care Research Network's Viral Infection and Respiratory Illness Universal Study creates a real-time COVID-19 registry of current ICU and hospital care patterns.

What is the recommended role of serial laboratory studies, including troponin, creatin kinase and D-dimer in the management of a hypercoagulable state?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered.

SCCM Pod-413 COVID-19 Fact Versus Science Fiction

Explore the need for randomized COVID-19 clinical trials and the difficulties and potential consequences of misinformation (Ingraham N, et al. Crit Care Explor. 2020;2:e0108) with host Ashish K. Khanna, MD, FCCP, FCCM, and Nicholas E. Ingraham, MD.