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Tag: COVID-19

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The Ties That Bind: A Coronavirus Disease Journey

From Critical Care Explorations

In this article, the authors describe a personal experience of COVID-19 bringing two old friends together and the patient care lessons learned.


Evaluation of the Efficacy and Safety of Inhaled Epoprostenol and Inhaled Nitric Oxide for Refractory Hypoxemia in Patients With Coronavirus Disease 2019

From Critical Care Explorations

In this study, the authors evaluated the efficacy and safety of inhaled epoprostenol and inhaled nitric oxide in patients with refractory hypoxemia secondary to coronavirus disease 2019.


Spectrum of Vascular Involvement in Coronavirus Disease 2019 Pneumonia—Findings on CT Perfusion

From Critical Care Explorations

In this article, the authors observed and interpreted CT perfusion patterns of COVID-19 pulmonary features.


Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019

From Critical Care Explorations

The authors examined whether increasing time between admission and intubation was associated with mortality in patients with coronavirus disease 2019 who underwent mechanical ventilation.


Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers

From Critical Care Explorations

The authors performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to identify potential diagnostic/prognostic biomarkers.


Resolution of Coronavirus Disease 2019 Infection and Pulmonary Pathology With Nebulized DAS181: A Pilot Study

From Critical Care Explorations

The authors investigated the safety and effects of nebulized DAS181 on hypoxic coronavirus disease 2019 patients.


Benchmarking Critical Care Well-Being: Before and After the Coronavirus Disease 2019 Pandemic

From Critical Care Explorations

The authors examined the impact of COVID-19 with regard to well-being, measured as burnout and professional fulfillment, across critical care healthcare professionals, ICUs, and hospitals within a health system.


Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review

From Critical Care Explorations

The authors evalute the use of isoflurane in patients with coronavirus disease 2019–induced acute respiratory distress syndrome.


Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study

From Critical Care Medicine

The authors assessed the effect of almitrine, a selective pulmonary vasoconstrictor, on arterial oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome.


Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest?

From Critical Care Medicine

The authors describe the characteristics and outcomes of in-hospital cardiac arrest in coronavirus disease 2019 patients in rural Southwest Georgia.


Letter to the Editor: Clinical Risk Prediction Scores in Coronavirus Disease 2019: Beware of Low Validity and Clinical Utility

From Critical Care Explorations

In this Letter to the Editor, the authors discuss their study and how their results show that the early tools developed in a relatively small, homogenous patient population are unlikely to be clinically useful in different settings.


Rapid Implementation of Telecritical Care Support During a Pandemic: Lessons Learned During the Coronavirus Disease 2020 Surge in New York City

From Critical Care Explorations

The authors describe key elements for a New York City health system to rapidly implement telecritical care consultative services to a newly created ICU during the coronavirus disease 2020 patient surge.


High-Flow Nasal Cannula (HFNC) Use in COVID-19 Respiratory Failure

This presentation is an overview of HFNC use for COVID-19 patients. This is SCCM curated COVID-19 microlearning content.


Are there any issues related to the use of diagnostic and interventional radiology that would preclude the performance of certain tests in patients who are COVID-19-positive?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


What are the indications for post-discharge thromboprophylaxis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


If a patient reports shortness of breath but has an oxygen saturation of 95%, is this patient a candidate for dexamethasone?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Would you address some of the latest literature relating to COVID-19 in pediatric and obstetric patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Have steroids been used after discharge?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


After a patient has tested positive for COVID-19, when is the most appropriate time to administer remdesivir to maximize its effectiveness?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Is tracheostomy a possibility in some COVID-19 patients? What is the longest time a patient has been on mechanical ventilation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


What is your experience with COVID-19 patients and ECMO?

Despite remdesivir, dexamethasone, and twice-daily anticoagulation, a patient’s condition continues to deteriorate. The patient is intubated, and every possible ventilation mode has been tried. The P/F ratio is decreasing, and pressure ventilation is not working. What is your experience with COVID-19 patients and ECMO? This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


What is the perfect steroid? What are the differences among hydrocortisone, dexamethasone, and prednisone?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Which medications are used for a hemodynamically unstable intubated patient who is progressing toward or has developed acute respiratory distress syndrome? Are remdesivir or steroids used? What about anticoagulation, given the high risk of thrombosis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


A Shot in The Dark: COVID-19 Vaccine Update

A January 8, 2021, SCCM webcast focusing on COVD-19 vaccination served as a primer for healthcare professionals who will be among the first to receive vaccines.


What are some post-ICU and post-hospital COVID-19 complications?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Epiglottitis Case: A Unique Presentation of COVID-19 Infection

This resource is an case presentation of epiglottitis and COVID-19. This is a community developed COVID-19 microlearning resource.


What happens when a patient’s condition starts to deteriorate? What are the criteria for ICU admission and what percentage of patients eventually need ICU admission? Of those patients admitted to the ICU, what percentage become septic and hemodynamically

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


For a stable patient on the ward who needs 2 to 4 liters of oxygen, is hemodynamically stable, and does not seem to be deteriorating, would you start a medication such as remdesivir or steroids or would you wait until the patient’s condition starts to det

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Do you recommend calling pharmacy or infectious diseases for patients admitted to the ward with a positive COVID-19 test and some COVID-19 symptoms?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Are pharmacists well versed in which COVID-19 drugs to use?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


How does an emergency department nurse apply her skills to the ICU when asked to work as an ICU nurse? Does your hospital use any type of tiered staffing? Do you incorporate non-ICU nurses or non-ICU physicians into your ICU staffing?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


How would a nonintensivist manage a patient who needs high-flow oxygen or noninvasive ventilation but does not require immediate intubation who is admitted to the ward because no ICU beds are available?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Would you use remdesivir or steroids as early as admittance to the emergency department? Do you advocate their use?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


Would you discuss the concept of happy hypoxia, in which patients have a very low saturation rate? What does this mean to emergency department physicians, hospitalists, and nurses? Should we intubate these patients as soon as we see them in the emergency

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


When should patients first come to the hospital? What distinguishes between mild, moderate, and severe symptoms? Once they come to the hospital how do we evaluate them?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on November 4, 2020.


The Difficult Path Ahead: We Hear You and Are Here for You

SCCM released a statement to media imploring the public to rise to the challenge and follow recommended public health measures, such as mask wearing, social distancing, hand hygiene, avoiding large groups and staying home as much as possible. 


What do you think about the possibility of reinfection and poor clinical outcomes?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


What are your thoughts about triage for ICU admission, lack of equipment, lack of PPE, and lack of dialysis equipment?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


Can you discuss the psychological needs of the patient and family regarding family involvement and end-of-life issues

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


What treatments are available for both intubated and nonintubated COVID-19 patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


Can you discuss basic ICU management for COVID-19 patients in terms of gastrointestinal prophylaxis, venous thromboembolism prophylaxis, fluid monitoring, dietary requirements, sedation, and vasopressors?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


Can you share your experiences about receiving a lot of patients who were transferred to your hospital for advanced treatment such as mechanical ventilation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


What are the criteria for extubation? I have noticed that when COVID-19 patients are extubated using the same criteria used for other patients, they seem to have a tremendous air hunger and don't do as well. What has been your experience?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


Regarding respiratory support of COVID-19 patients both in and outside the ICU, can you discuss noninvasive ventilation, BiPAP, CPAP, and high-flow nasal cannula versus intubation? What are the indications for intubation? Intubate early or later?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


How was nurse staffing handled at your institution? Did you design a tiered staffing system for ICU nurses or did you use nurses from other departments? What was your experience with the nursing staff?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


How did your institution handle incorporating fellows, residents, and other non-ICU clinicians into a tiered staffing system? Did they care for patients? What do you recommend?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


Did you manage any acutely ill patients on the ward with noninvasive ventilation and proning? Did you prone nonintubated patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


What are the most common presenting signs and symptoms of COVID-19? What are the more serious signs of a life-threatening situation? What are the indications for ICU admission that non-ICU clinicians must be aware of?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on August 12, 2020.


What is double anticoagulation prophylaxis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


Are you using typical DVT prophylaxis or something more, such as therapeutic anticoagulation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection

From Critical Care Explorations. In this case report, the authors describe two cases of prolonged coma after weaning off sedation in severe acute respiratory syndrome coronavirus 2 with rapid neurologic improvement shortly after high-dose corticosteroid regimen.


Acute Kidney Injury in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus-2 Pandemic: Experience From PICUs Across United Kingdom

From Critical Care Medicine. The authors evaluated the prevalence, evolution, and clinical factors associated with acute kidney injury in children admitted to PICUs with pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus-2.


A Hybrid Model of Pediatric and Adult Critical Care During the Coronavirus Disease 2019 Surge: The Experience of Two Tertiary Hospitals in London and New York

From Pediatric Critical Care Medicine. In this report, the authors describe the hybrid model implemented at institutions in New York and London and discuss shared experiences, pitfalls, challenges, and adjustments required in caring for both young and older patients.


Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Possible Late Indication for Coronavirus Disease 2019?

From Critical Care Explorations. In this case report, the authors note that late extracorporeal membrane oxygenation may be considered in selected patients as a bridge to recovery. Further prospective studies are, however, needed.


Timing of Intubation and Its Implications on Outcomes in Critically Ill Patients With Coronavirus Disease 2019 Infection

From Critical Care Explorations. In this Letter to the Editor, the authors report their findings from an observational study aimed to compare the difference in outcomes of critically ill patients with coronavirus disease 2019 who were intubated early versus later in the disease course.


Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020

From Critical Care Medicine. The authors measured temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and assessed whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time.


SCCM Pod-427 Severe COVID-19 and Sepsis

Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection.


Concise Critical Appraisal: Is CPR Futile for COVID-19 Patients?

Is cardiopulmonary resuscitation (CPR) futile in hospitalized patients with COVID-19 experiencing cardiac arrest? A study recently published in Critical Care Medicine sought to answer this question and provide more data around outcomes of in-hospital cardiac arrest in patients with COVID-19.


SCCM Pod-427 Severe COVID-19 and Sepsis

Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection. Explore the definition of sepsis and overlap with case descriptions of patients with severe COVID-19, treatment, and more. 


What is double anticoagulation prophylaxis?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


Are you using typical DVT prophylaxis or something more, such as therapeutic anticoagulation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


If a patient has had COVID-19 for 3 weeks and is still short of breath and fatigued and has a lot of ground-glass opacities on radiograph, should this patient receive steroids?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


What is your typical medication regimen for COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


What is your center’s approach to supporting another center if it has a COVID-19 patient who may need intubation? What advice do you have for smaller centers that may have a potential COVID-19 patient who needs ventilation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


What is your perspective on the approach to mechanical ventilation for COVID-19 patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


How do you achieve a balance between staff safety and PPE use and assessing patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


How do emergency department staff identify patients who need critical care? How are these patients triaged, and what criteria are used to determine whether patients are transferred to a ward, to the ICU, or to home?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


What is the approach in the emergency department for patients who arrive with potential COVID-19 symptoms? What triage, diagnostic, and treatment practices are in place?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


What sticks out for you in terms of what has changed going into the second wave of the pandemic? What are some key issues and what should we expect going forward?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on October 14, 2020.


Are you using convalescent plasma in your practice?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Does literature on the peripheral vascular administration of vasoactive drugs apply to children as well as adults?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Should dexamethasone or remdesivir be started on a patient who requires oxygen via nasal cannula and is highly suspected of having COVID-19 if test results are still pending?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


What is the time frame for placing vascular catheters in these patients for administration of vasoactive drugs?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Have you become more aggressive in placing arterial lines in these patients when you might have only monitored pulse oximetry in the past?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


What is the difference between pulse oximetry and arterial oxygen tension

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


How do approaches for children differ from those for adults?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Are you using steroids, including dexamethasone, in your adult and pediatric practices?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


What is the best way to determine when mechanically ventilated patients should be transitioned to noninvasive ventilation?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


What is the practice in your institution for confusion, dementia, and mobilization in these patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Which type of nutrition support is most appropriate for severely injured patients?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


How should anticoagulation be approached in the critically ill patient with COVID-19?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


How should patients who require mechanical ventilation be identified and how should initial ventilator settings be determined?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on September 9, 2020.


Vitamin Treatment and Renin-Angiotensin System Inhibition in Patients with COVID-19

During this 1-hour activity expert faculty from the American Society of Health-System Pharmacists and the Society of Critical Care Medicine discussed the use of vitamins as adjunctive treatment in patients with COVID-19 as well as the role of Renin-Angiotensin System Inhibition in COVID-19 patients.


Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019–Induced Vasodilatory Shock: A Retrospective Matched Cohort Study

From Critical Care Explorations. In this study, the authors found that angiotensin-II treatment for coronavirus disease 2019–induced distributive shock was associated with rapid improvement in multiple physiologic indices and that angiotensin-II in coronavirus disease 2019–induced shock warrants further study.


Extracorporeal Membrane Oxygenation Retrieval in Coronavirus Disease 2019: A Case-Series of 19 Patients Supported at a High-Volume Extracorporeal Membrane Oxygenation Center

From Critical Care Explorations. In this observational study, the authors concluded that extracorporeal membrane oxygenation retrieval can rescue young, previously healthy patients with severe coronavirus disease 2019 in whom all the conventional respiratory measures have failed and found that thrombotic and hemorrhagic complications are frequent in this cohort.


Persevering With Prone Ventilation in Coronavirus Disease 2019 Pneumonia

From Critical Care Explorations. In this case study, the authors present a 53-year-old patient with a severe coronavirus disease 2019 pneumonia who has made a remarkable recovery after a difficult period on intensive care.


Letter to the Editor: Declines in Mortality Over Time for Critically Ill Adults With Coronavirus Disease 2019

From Critical Care Medicine. In this Letter to the Editor, the authors report an update to a previous study, finding a decline in mortality rates in critically ill patients with COVID-19.


Caring for Critically Ill Children With Suspected or Proven Coronavirus Disease 2019 Infection: Recommendations by the Scientific Sections’ Collaborative of the European Society of Pediatric and Neonatal Intensive Care

From Pediatric Critical Care Medicine. In this article, the authors review the current clinical knowledge of coronavirus disease 2019 disease in critically ill children and discuss some specific treatment concepts based mainly on expert opinion based on limited experience and the lack completed controlled trials in children at the time of the paper.


Multisystem Inflammatory Syndrome in Children Associated With Coronavirus Disease 2019 in a Children's Hospital in New York City

From Pediatric Critical Care Medicine. In this article, the authors report their experience developing a clinical inpatient protocol for the evaluation, management, and follow-up of patients with multisystem inflammatory syndrome.


Letter to the Editor: Prevalence and Clinical Correlates of Echo-Estimated Right and Left Heart Filling Pressures in Hospitalized Patients With Coronavirus Disease 2019

From Critical Care Explorations In this Letter to the Editor, the authors discuss their study in which they hypothesized that a significant proportion of coronavirus disease 2019 patients has evidence of pulmonary hypertension associated with elevated left heart filling pressure on transthoracic echocardiography.


Clinical Outcomes Following Tocilizumab Administration in Mechanically Ventilated Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this study, the authors examined the outcomes of critically ill coronavirus disease 2019 patients treated with tocilizumab and factors associated with clinical improvement.


The POSITIONED Study: Prone Positioning in Nonventilated Coronavirus Disease 2019 Patients - A Retrospective Analysis

From Critical Care Explorations. In this study, the authors investigated explored whether awake self-proning improved outcomes in coronavirus disease 2019-infected patients treated in a rural medical center with limited resources during a significant local coronavirus disease 2019 outbreak.


Delayed Development of Coronary Artery Dilitation in Suspected Severe Acute Respiratory Syndrome Coronavirus 2 Multisystem Inflammatory Syndrome: More Research Needed

From Critical Care Explorations. In this case report, the authors describe a pediatric patient with coronavirus disease-19-associated multisystem inflammatory syndrome without robust hyperinflammation and a delayed finding of coronary artery dilatation, which they believe highlights the need for further mechanistic understanding of coronavirus disease-19 disease and subsequent multisystem inflammatory syndrome in children or Kawasaki disease development.


Convalescent Plasma Therapy in Four Critically Ill Pediatric Patients With Coronavirus Disease 2019: A Case Series

From Critical Care Explorations. In this case report, the authors report a series of four critically ill pediatric patients with acute respiratory failure who received coronavirus disease 2019 convalescent plasma as a treatment strategy for severe disease.


Antiviral Dosing Modification for Coronavirus Disease 2019–Infected Patients Receiving Extracorporeal Therapy

From Critical Care Explorations. In this study, the authors gathered available published resources including physicochemical and pharmacokinetic properties and suggest antiviral drug dosing adaptation for coronavirus disease 2019–infected critically ill patients receiving extracorporeal therapy.


Three-Dimensional Printed Ventilators: A Rapid Solution to Coronavirus Disease 2019–Induced Supply-Chain Shortages

From Critical Care Explorations. In this paper, the authors report that three-dimensional printed ventilators, such as "CRISIS," propose a potential solution to increase the available number of vents for the United States and abroad, one that is dynamic and able to absorb the massive influx of hospitalized patients for the foreseeable future.


Quantification of Neurological Blood-Based Biomarkers in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations. In this study, the authors sought to provide an objective characterization of acute neurologic injury in critically ill patients with coronavirus disease 2019.


SCCM Pod-423 Coagulopathy in COVID-19 Patients

COVID-19 is associated with a high prevalence of coagulopathy and venous thromboembolism. Host B. Kyle Enfield, MD, FCCM, talks with Jerrold H. Levy, MD, FAHA, FCCM, about what clinicians need to know about this serious problem and how it impacts care delivery (Iba et al. Crit Care Med. 2020;48:1358-1364).


SCCM Pod-422 Procalcitonin in COVID-19 and Influenza-Related Secondary Bacterial Infections

Procalcitonin testing on admission seems to be a valuable piece of information for early risk assessment and ruling out bacterial co-infection in COVID-19 patients.


SCCM Pod-421 COVID-19 and Renal Replacement Therapy

The increase in acute kidney injury in COVID-19 patients is resulting in more utilization of renal replacement therapy (RRT) and continuous renal replacement therapy (CRRT).


COVID-19: What’s Next: A Deeper Dive into Top Sessions

COVID-19: What’s Next, the first-of-its kind virtual conference hosted by the Society of Critical Care Medicine (SCCM), featured the newest research findings, epidemiologic models, and guideline updates for caring for patients with COVID-19 from specialists on the front lines.


The Impact of the Novel Coronavirus on Brazilian PICUs

From Pediatric Critical Care Medicine. The authors evaluated the impact of the coronavirus disease 2019 pandemic, considering the physical distancing and schools closing, on the characteristics of admission and epidemiology on Brazilian PICUs.
 


Treatment for Severe Coronavirus Disease 2019 With the Seraph-100 Microbind Affinity Blood Filter

From Critical Care Explorations. The authors sought to determine whether Seraph-100 (Exthera Medical Corporation, Martinez, CA) treatment provides clinical benefit for severe coronavirus disease 2019 cases that require mechanical ventilation and vasopressor support.


Point-of-Care Lung Ultrasound for Detecting Severe Presentations of Coronavirus Disease 2019 in the Emergency Department: A Retrospective Analysis

From Critical Care Explorations. In this study, lung ultrasound diagnosed severe presentations of coronavirus disease 2019 with similar sensitivity to chest radiograph, CT, and reverse transcriptase-polymerase chain reaction (on first testing) and improved specificity compared to chest radiograph.
 


Letter to the Editor: Weaning by Surgical Tracheostomy and Portable Ventilators Released ICU Ventilators During Coronavirus Disease 2019 Surge in London

From Critical Care Explorations. In this Letter to the Editor from London, the authors share experiences with an integrated model of surgical tracheostomy weaning of respiratory critical care patients by a specialist mobile weaning team, using tracheostomy-licensed ventilators, and noted that it appears safe, effective and may be transferrable to other healthcare systems where ICU resource limitation is a reality during the COVID-19 pandemic.


Mortality Rates in a Diverse Cohort of Mechanically Ventilated Patients With Novel Coronavirus in the Urban Midwest

From Critical Care Explorations. In this study, the authors found mortality rates in mechanically ventilated patients with coronavirus disease 2019 to be lower than some previously reported with longer lengths of stay.
 


Letter to the Editor: Impact of Asynchronies in Acute Respiratory Distress Syndrome Due to Coronavirus Disease 2019

From Critical Care Explorations. In this Letter to the Editor, the authors state that close monitoring of patients with COVID-19 and mechanical ventilation is required; staying at the patient’s bedside is necessary to identify life-threatening asynchronies and must be resolved promptly, as well as finding strategies for prevention of asynchronies. 
 


Letter to the Editor: Tracheostomy for Coronavirus Disease 2019 Patients: Maintaining the Standard of Care

From Critical Care Explorations. In this Letter to the Editor, the authors respond to the new recommendations for delaying tracheostomy for coronavirus disease 2019 patients to day 21 post-intubation to ensure viral clearance.
 


Letter to the Editor: Urinary Neutrophil Gelatinase-Associated Lipocalin in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations. In this Letter to the Editor, the authors report a retrospective analysis of urinary neutrophil gelatinase-associated lipocalin (NGAL) in ICU patients with COVID-19-associated respiratory failure. 
 


Letter to the Editor: The Triage Stalemate During the Coronavirus Disease 2019 Pandemic: Losing Fairness to Ethical Paralysis

From Critical Care Medicine. The authors write in response to an article in Critical Care Medicine by Sprung et al., which outlined the major considerations for ethical ICU triaging under pandemic conditions and discuss the lack of systematic triaging in U.S. health care institutions.
 


Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

From Critical Care Medicine. The authors present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.
 


High-Flow Nasal Oxygen in Coronavirus Disease 2019 Patients With Acute Hypoxemic Respiratory Failure: A Multicenter, Retrospective Cohort Study

From Critical Care Medicine. In this study, the authors analyzed the effectiveness of high-flow nasal oxygen treatment and aimed to identify the variables predicting high-flow nasal oxygen treatment failure in coronavirus disease 2019 patients with acute hypoxemic respiratory failure.
 


Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York City

From Critical Care Medicine. In this study from New York, NY, the authors found that hyponatremia occurred in nearly a third of coronavirus disease 2019 patients, was an independent predictor of in-hospital mortality, and was associated with increased risk of encephalopathy and mechanical ventilation.
 


Foreword: Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?

From Critical Care Medicine. In this foreword, the authors contend that there should be no debate that SARS-CoV-2 is an important cause of sepsis and that labeling it as such is beneficial and appropriate.


Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection

From Critical Care Medicine. In this single center study, the authors found that plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection.
 


Novel Outcome Biomarkers Identified With Targeted Proteomic Analyses of Plasma From Critically Ill Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this study, the authors found that targeted proteomics with feature classification easily distinguished both healthy control subjects and coronavirus disease 2019 tested negative ICU patients from coronavirus disease 2019 tested positive ICU patients. Multiple proteins were identified that accurately predicted coronavirus disease 2019 tested positive patient mortality.


Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation

From Critical Care Explorations. The authors found that thrombosis profiling identified endothelial activation and glycocalyx degradation in coronavirus disease 2019 positive patients and believe that the data from this study suggest that medications to protect and/or restore the endothelial glycocalyx, as well as platelet inhibitors, should be considered for further study.


Editorial: Pediatric Sepsis in the Time of Coronavirus Disease 2019

From Pediatric Critical Care Medicine. In this editorial, the author reviews ""Perspectives on Pediatric Sepsis in Patients with COVID-19"" from the Surviving Sepsis Campaign Pediatric Guidelines Taskforce authors.
 


Does Pulmonary Aspergillosis Complicate Coronavirus Disease 2019?

From Critical Care Explorations. In this article, the authors summarize what is known about coronavirus disease 2019 complicated by Aspergillus, introduces coronavirus disease 2019–associated pulmonary aspergillosis as a possible clinical entity, and describes reasons clinical suspicion of Aspergillus is warranted in the critical care setting.
 


Dexmedetomidine-Associated Hyperpyrexia in Three Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations. In this study of three patients, the authors state that their findings suggest that high doses of dexmedetomidine infusion are associated with hyperpyrexia in a seemingly dose-dependent fashion in critically ill patients with coronavirus disease 2019.
 


Thromboelastography to Detect Hypercoagulability and Reduced Fibrinolysis in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients

From Critical Care Explorations. In this study, the authors investigated thromboelastography in patients with coronavirus disease 2019-associated acute respiratory distress syndrome with the goal of characterizing suspected coagulopathy and impaired fibrinolysis.
 


Disseminated Multifocal Intracerebral Bleeding Events in Three Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation As Rescue Therapy

From Critical Care Explorations. In this article, the authors describe three coronavirus disease 2019 patients suffering from acute respiratory distress syndrome under venovenous extracorporeal membrane oxygenation therapy and tight anticoagulation monitoring presenting a novel pattern of multifocal brain hemorrhage in various degrees in all cerebral and cerebellar lobes.
 


Letter to the Editor: Transforming a PICU Into an Adult ICU During the Coronavirus Disease 2019 Pandemic: Meeting Multiple Needs

From Critical Care Explorations. In this Letter to the Editor, the authors describe the process converting half of their 40-bed PICU into a negative-pressure biocontainment ICU dedicated to adult coronavirus disease 2019 patients within a 1,003-bed academic quaternary hospital.


Probative Value of the D-Dimer Assay for Diagnosis of Deep Venous Thrombosis in the Coronavirus Disease 2019 Syndrome

From Critical Care Medicine.The authors describe the predictive utility of the D-dimer assay among patients with the coronavirus disease 2019 syndrome for unprovoked lower extremity deep venous thrombosis.


Editorial: Coronavirus Disease 2019 Prediction Modeling: Everything Old Is NEWS Again

From Critical Care Medicine. In this Editorial, the authors comment on the article by Liu et al. “Evaluation of the Risk Prediction Tools for Patients With Coronavirus Disease 2019 in Wuhan, China: A Single-Centered, Retrospective, Observational Study” and note that tools developed for general critical illness can be leveraged for COVID-19 patient care.


Effects of Positive End-Expiratory Pressure in “High Compliance” Severe Acute Respiratory Syndrome Coronavirus 2 Acute Respiratory Distress Syndrome

From Critical Care Medicine. In this study, the authors state their data suggest that a ""higher” positive end-expiratory pressure approach in patients with severe acute respiratory syndrome coronavirus 2 acute respiratory distress syndrome and high compliance improves oxygenation and lung aeration but may result in alveolar hyperinflation and hemodynamic alterations.
 


Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019

From Critical Care Explorations. The authors sought to determinewhether placental cell therapy PLacental eXpanded (PLX)-PAD (Pluristem Therapeutics, Haifa, Israel) was beneficial to treating critically ill patients suffering from acute respiratory distress syndrome due to coronavirus disease 2019.
 


Tokyo and New York: A Study in the Contrasting Effects of Socioeconomic Status on Coronavirus Disease 2019 Outcomes

From Critical Care Explorations. The authors examined the association between socioeconomic status and the rate of coronavirus disease 2019 infections using public data from Tokyo.


Editorial: Delivering Care From an Unstable Evidence Base: The Evolving Care of Coronavirus Disease 2019 Through the Lens of High-Flow Nasal Oxygen

From Critical Care Medicine. In this Editorial, the authors discuss the challenges of caring for patients with COVID-19 without evidence to guide them through the lens of high-flow nasal oxygenation and how there have been slow changes for improvement.


Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry

From Critical Care Medicine. In this article, the authors describe how the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study coronavirus disease 2019 registry sought to develop and implement prespecified best practices combined with grassroots efforts from clinical sites worldwide in order to develop clinically useful knowledge in response to a pandemic.
 


Coronavirus Disease 2019 and Acute Respiratory Distress Syndrome: Why the Intensivist Is More Important Than Ever

From Critical Care Medicine. In this Viewpoints article, the authors discuss the challenges of ARDS in COVID-19 patients.


Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Guideline-Driven Care Should Be Our Natural Reflex

From Critical Care Medicine. In this Viewpoints article, the authors discuss the value of evidence-based, guidelines-driven care in ARDS in patients with COVID-19.
 


The Association of Inflammatory Cytokines in the Pulmonary Pathophysiology of Respiratory Failure in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations. The authors investigated  the pathophysiological relationship between proinflammatory cytokines and respiratory failure in severe coronavirus disease 2019.


Molecular Diagnosis of Coronavirus Disease 2019

From Critical Care Explorations. In this article, the authors review current approaches to the molecular diagnosis of coronavirus disease 2019.


Increased Dead Space Ventilation and Refractory Hypercapnia in Patients With Coronavirus Disease 2019: A Potential Marker of Thrombosis in the Pulmonary Vasculature

From Critical Care Explorations. This case series highlights clinical findings and management of coronavirus disease 2019 patients with refractory hypercapnia despite maximal/optimal ventilatory support.


Subcutaneous Emphysema, Pneumomediastinum, and Pneumothorax in Critically Ill Patients With Coronavirus Disease 2019: A Retrospective Cohort Study

From Critical Care Explorations. In this observational study, the authors describe patients with barotrauma, which appears to be a common complication of severe coronavirus disease 2019. 


Inpatient Mortality According to Level of Respiratory Support Received for Severe Acute Respiratory Syndrome Coronavirus 2 (Coronavirus Disease 2019) Infection: A Prospective Multicenter Study

From Critical Care Explorations. In this study, the authors describe patients according to the maximum degree of respiratory support received and report their inpatient mortality due to coronavirus disease 2019.


Letter to the Editor Treatment of Critically Ill Coronavirus Disease 2019 Patients With Adjunct Therapeutic Plasma Exchange: A Single-Center Retrospective Case Series

From Critical Care Explorations. In this Letter to the Editor, the authors describe their experience with a series of eight patients receiving adjunct therapeutic plasma exchange for severe coronavirus disease pneumonia complicated by sepsis with multiple organ dysfunction in which C-reactive protein and ferritin levels significantly decreased with therapeutic plasma exchange, whereas D-dimer decreased to a lesser degree.


In Silico Modeling of Coronavirus Disease 2019 Acute Respiratory Distress Syndrome: Pathophysiologic Insights and Potential Management Implications

From Critical Care Explorations. In this study, the authors adapted a high-fidelity computational simulator to develop quantitative insights into the key pathophysiologic differences between the coronavirus disease 2019 acute respiratory distress syndrome and the conventional acute respiratory distress syndrome and to assess the impact of different positive end-expiratory pressure, Fio2, and tidal volume settings.


Letter to the Editor: Early Clinical Experience in Using Helmet Continuous Positive Airway Pressure and High-Flow Nasal Cannula in Overweight and Obese Patients With Acute Hypoxemic Respiratory Failure From Coronavirus Disease 2019

From Critical Care Explorations. In this Letter to the Editor, the authors present their retrospective review of COVID-19 patients admitted to the ICUs within two academic urban hospitals (1,012 total hospital beds), comparing helmet continuous positive airway pressure and high-flow nasal cannula in patients with a body mass index greater than or equal to 25 kg/m2 who had persistent hypoxemia.


SCCM Pod-423 Coagulopathy in COVID-19 Patients

COVID-19 is associated with a high prevalence of coagulopathy and venous thromboembolism. Explore what clinicians need to know about this serious problem and how it impacts care delivery.


SCCM Pod-422 Procalcitonin in COVID-19 and Influenza-Related Secondary Bacterial Infections

Procalcitonin testing on admission seems to be a valuable piece of information for early risk assessment and ruling out bacterial co-infection in COVID-19 patients. Host Pamela M. Peeke, MD, MPH, is joined by Michael Broyles, PharmD, and Eric H. Gluck, MD, to explore this topic.


SCCM Pod-421 COVID-19 and Renal Replacement Therapy

The increase in acute kidney injury in COVID-19 patients is resulting in more utilization of renal replacement therapy (RRT) and continuous renal replacement therapy. Host Pamela M. Peeke, MD, MPH, FACP, FACSM , is joined by Michael J. Connor Jr, MD, to review RRT utilization.


Concise Critical Appraisal: Dexamethasone Use in the Treatment of COVID-19

This Concise Critical Appraisal offers a look into the results of the RECOVERY trial published in the New England Journal of Medicine, which demonstrated that dexamethasone improved mortality in hospitalized patients with COVID-19.


SCCM Experts Weigh in on Latest COVID-19 Treatment Strategies

This article distills some of the challenges and lessons learned in key areas of COVID-19 management: convalescent plasma therapy and strategies for diabetes/hyperglycemia and myocarditis.


Relocating IV Pumps for Critically Ill Isolated Coronavirus Disease 2019 Patients From Bedside to Outside the Patient Room

From Critical Care Explorations. The authors discuss advantages and disadvantages of relocating IV pumps for coronavirus disease 2019 patients from bedside to outside the patient room and characterize reproducible details of an external infusion pump model.


Evaluation of Coronavirus Disease 2019 Severity Using Urine Biomarkers

From Critical Care Explorations. The authors conducted a study to determine whether noninvasive urine biomarkers can predict the clinical severity of coronavirus disease 2019.


Editorial: Coronavirus Disease 2019: A Tsunami of Data and a Plethora of Unanswered Questions

From Pediatric Critical Care Medicine. In this editorial, the author discusses issues emerging from the study by Bhumbra et al. (Clinical features of critical coronavirus disease 2019 in children) that are worthy of discussion and further exploration, including the predilection for racial minorities, similarities and differences to sepsis, wide expression of clinical disease, and the conundrum of providing family centered care.


Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019

From Pediatric Critical Care Medicine. In this article, the authors discuss the Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children as they relate to COVID-19.


Critical Care for Coronavirus Disease 2019: Perspectives From the PICU to the Medical ICU

From Critical Care Medicine. The authors describe the unique perspective of pediatric intensivists caring for critically ill adults during the coronavirus disease 2019 pandemic.


Letter to Editor: In Response to "Coagulopathy of Coronavirus Disease 2019"

From Critical Care Medicine. This Letter to the Editor is in response to the article "Coagulopathy of Coronavirus 2019" by Iba et a.


Obesity and the Risk of Intubation or Death in Patients With Coronavirus Disease 2019

From Critical Care Medicine. In the study, obesity was an independent risk factor for intubation or death.


Evaluation of the Risk Prediction Tools for Patients With Coronavirus Disease 2019 in Wuhan, China: A Single-Centered, Retrospective, Observational Study

From Critical Care Medicine. In this study from China, the authors evaluated and compared the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-related Organ Failure Assessment on predicting in-hospital death in patients with coronavirus disease 2019.


Higher Intensity Thromboprophylaxis Regimens and Pulmonary Embolism in Critically Ill Coronavirus Disease 2019 Patients

From Critical Care Medicine. In this study from Belgium, the authors assessed the role of thromboprophylaxis regimens on the occurrence of pulmonary embolism in coronavirus disease 2019 patients.


Role for Anti-Cytokine Therapies in Severe Coronavirus Disease 2019

From Critical Care Explorations. In this narrative review, the authors summarize existing knowledge of the immune response to coronavirus infection and highlight the current and potential future roles of therapeutic strategies to combat the hyperinflammatory response of patients with coronavirus disease 2019.


Nationwide Incidence and Outcomes of Patients With Coronavirus Disease 2019 Requiring Intensive Care in Iceland

From Critical Care Medicine. In this study from Iceland, which had early adoption of widespread testing, the authors report a lower overall ratio of ICU admissions for coronavirus disease 2019 among severe acute respiratory syndrome coronavirus 2 positive patients and a lower hospital mortality for patients treated in the ICU for coronavirus disease 2019 compared with initial reports from Italy and China.


Principles Guiding Nonpandemic Critical Care Research During a Pandemic

From Critical Care Medicine. In this article, the authors describe the importance of critical care clinical research that is not pandemic-focused during pandemic times; outline principles to assist in the prioritization of nonpandemic research during pandemic times; and propose a guiding framework for decisions about whether, when and how to continue nonpandemic research while still honoring the moral and scientific imperative to launch research that is pandemic-focused.


Letter to the Editor: Concerns About the Timing and Settings of Initiating Extracorporeal Membrane Oxygenation in Patients With Severe Coronavirus Disease 2019 Pneumonia

From Critical Care Medicine. In this Letter to the Editor, the author respond to an article by Yang et al about COVID and ECMO.


Intracranial Pressure Dynamics and Cerebral Vasomotor Reactivity in Coronavirus Disease 2019 Patient With Acute Encephalitis

From Critical Care Explorations. In this article, the authors describe the intracranial pressure dynamics and cerebral vasomotor reactivity in a coronavirus disease 2019 patient with acute encephalitis treated with cerebrospinal fluid drainage and therapeutic plasma exchange.


Myoclonus in Patients With Coronavirus Disease 2019: A Multicenter Case Series

From Critical Care Medicine. The authors describe the risk factors for and outcomes after myoclonus in a cohort of patients with coronavirus disease 2019.


Core Outcomes Set for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The authors aimed to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019.


International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The author set out to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 trials.


Timing of Intubation and Mortality Among Critically Ill Coronavirus Disease 2019 Patients: A Single-Center Cohort Study

From Critical Care Medicine. The authors examined the impact of time to intubation and use of high-flow nasal cannula on clinical outcomes in patients with coronavirus disease 2019.


Coronavirus Disease 2019 Intermediate Care Units: Containing Escalation of ICUs

From Critical Care Medicine. In this Letter to the Editor, the authors share their view that - for COVID-19 patient - Intermediate Care Units (IMCUs) may be better suited for post-ICU care than ordinary hospital wards.


Renin-Angiotensin System and COVID-19

This presentation is a review of the renin-angiostensin System and COVID-19. This is SCCM curated COVID-19 microlearning content.


COVID-19 Pharmacology Debates: Management of Delirium, Pain and Sedation

The Society of Critical Care Medicine (SCCM) and the American Society of Health-System Pharmacists (ASHP) in their third series of therapeutic debates in the management of COVID-19.


COVID-19 Pharmacology Debates: Steroid and Antiviral Use in COVID-19 Patients

ASHP and the SCCM teamed up in their second series of therapeutic debates in the management of COVID-19. In the first debate, the content matter experts reviewed the latest literature and debate the use of steroids for treatment of COVID-19.


EEG Changes Associated with COVID-19

An expert panel representing the Society of Critical Care Medicine (SCCM) and the Neurocritical Care Society (NCS) teamed up to discuss cEEG monitoring and implementation of a cEEG program in COVID-19 patients, seizure detection, utility and treatment implications, along with practical considerations.


Critical Care Documentation and Billing Update: COVID-19 Pandemic

This article was originally published in the Summer 2020 Issue of Critical Connections.


PTSD and Burnout in Healthcare Professionals

This article was originally published in the Summer 2020 Issue of Critical Connections.


ICU vs. PICU Liberation: Same Goals, Different Tools

This presentation discusses the difference in ICU and PICU liberation to implement the ICU Liberation Bundle in patients with COVID-19. This is SCCM curated COVID-19 microlearning content.


Incidence of Venous Thromboembolism in Critically Ill Coronavirus Disease 2019 Patients Receiving Prophylactic Anticoagulation

From Critical Care Medicine. Deep venous thrombosis is very common in critically ill patients with coronavirus disease 2019, so the authors describe the prevalence of venous thromboembolism in critically ill patients receiving different regimens of prophylactic anticoagulation.


Letter to the Editor: Barrier Techniques to Reduce Aerosolization During Extubation

From Critical Care Explorations. The authors describe a barrier technique during extubation which contained aerosolized particulates into a non-rebreather mask at time of extubation. The authors believe their protocol allows providers to perform extubations while minimizing exposure to aerosolized particles.


Letter to the Editor: Barrier Techniques to Reduce Aerosolization During Cardiopulmonary Resuscitation

From Critical Care Explorations. The authors developed additional modifications to the suggested guidelines to further protect providers from unnecessary aerosolization; it illustrates a sample protocol for provider safety during advanced cardiovascular life support in the coronavirus pandemic.


Editorial: Extracorporeal Membrane Oxygenation During the Coronavirus Disease 2019 Pandemic

From Critical Care Medicine. In this editorial, the authors discuss the important role of extracorporeal membrane oxygenation as a rescue therapy for patients with SARS-CoV-2 pneumonia associated with severe ARDS.


Thromboelastography Profiles of Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Medicine. The authors reviewed thromboelastography studies in critically ill patients with coronavirus disease 2019 to characterize their coagulation states.


Letter to the Editor: Coronavirus Disease 2019: Understanding Immunopathogenesis Is the “Holy Grail” to Explain Why Children Have Less Severe Acute Disease

From Pediatric Critical Care Medicine. In this letter to the editor, the authors state that the understanding of the immunopathogenesis of SARS-CoV-2 infection is important not only to understand the epidemiologic and age-related differences in COVID-19, but it is critical for the identification of appropriate treatment, as well as for the development of a highly immunogenic vaccine with low risk of antibody dependent enhancement.


Pediatric Resuscitation Practices During the Coronavirus Disease 2019 Pandemic

From Pediatric Critical Care Medicine. The authors conducted a survey and found that most U.S. pediatric institutions rapidly adapted their resuscitation systems and practices in response to the coronavirus disease 2019 pandemic.


Coronavirus Disease 2019 Pandemic Measures: Reports From a National Survey of 9,120 ICU Clinicians

From Critical Care Medicine. In this national ICU clinician survey, it was found that there are continued concerns regarding personal protective equipment supplies with the chief issue being N95 respirator availability.


Clinical Features of Critical Coronavirus Disease 2019 in Children

From Pediatric Critical Care Medicine. In this study, the authors observed a greater proportion of hospitalized children requiring mechanical ventilation than has been reported to date; they state that older children, African-American or Hispanic children, and males may be at greater risk for severe illness requiring hospitalization.


Venous Thromboembolism Events Following Venovenous Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Syndrome Coronavirus 2 Based on CT Scans

From Critical Care Medicine. The authors report a 100% occurrence of venous thromboembolism in critically ill patients supported by venovenous extracorporeal membrane oxygenation for severe acute respiratory syndrome coronavirus 2-related acute respiratory distress syndrome using CT scan imaging despite a high target and close monitoring of anticoagulation.


The Impact of Coronavirus Disease 2019 Pandemic on U.S. and Canadian PICUs

From Pediatric Critical Care Medicine. This study found that patients with coronavirus disease 2019 have a high frequency of comorbidities, require longer stays, more ventilatory support than usual PICU admissions, suggesting several avenues for further exploration.


Letter to the Editor: Optimizing the Risk-Benefit Balance of Thromboprophylaxis in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Medicine. This Letter to the Editor is in response to an article by Iba et al. (Coagulopathy of Coronavirus Disease 2019) and discusses dosing recommendations of low molecular weight heparin.


Editorial: Lessons Learned From the Front Line: Outcomes of Noninvasive Ventilation for Coronavirus Disease 2019 Pneumonia in China

From Critical Care Medicine. In this Editorial, the authors look at the study by Wang et al. (Clinical Features of Coronavirus Disease 2019 Patients With Mechanical Ventilation: A Nationwide Study in China)


Editorial: Financial Toxicity After Hospitalization; Considerations in Coronavirus Disease 2019 Recovery

rom Critical Care Medicine. In this Editorial, the authors comment on an article by Hauschildt et al. (Financial Toxicity After Acute Respiratory Distress Syndrome: A National Qualitative Cohort Study).


Leveraging Tele-Critical Care Capabilities for Clinical Trial Consent

From Critical Care Explorations. In this article, the authors share their experience with a patient with severe COVID-19 who was admitted to a clinical trial of an investigational COVID-19 therapeutic using video-telecommunication to obtain informed consent.


Procedures for COVID-19 Cohort Units: Building an Operating Room in a COVID-19 Cohort ICU

This presentation provides procedures for building COVID-19 cohort units. This is SCCM curated COVID-19 microlearning content.


Approaching delirium in patients with COVID-19

This presentation provides an overview of the types of strategies for approaching the D Element (Delirium) of the ICU Liberation Bundle in patients with COVID-19. This is SCCM curated COVID-19 microlearning content.


Letter to the Editor: Thromboprophylaxis in Critically Ill Coronavirus Disease 2019 Patients

From Critical Care Explorations. In this Letter to the Editor, the authors report their adapted thromboprophylaxis practice of low-molecular-weight heparin administration in coronavirus disease 2019 ICU patients.


Preparedness and Reorganization of Care for Coronavirus Disease 2019 Patients in a Swiss ICU: Characteristics and Outcomes of 129 Patients

From Critical Care Explorations. The authors report their experience in Switzerland with regard to ICU organization and anticipation, as well as patient characteristics, treatment, and outcomes.


PPE Strategies for the COVID-19 Era

The supply of personal protective equipment (PPE) has been uncertain since the start of the COVID-19 pandemic. Months into this healthcare crisis, supply chains are unpredictable as reports of shortages continue. Follow these key strategies for managing PPE.


Alternative Analgesic and Sedative Agents in the Setting of Drug Shortages during the COVID19 Pandemic

This resources detail how to manage drug shortages for alternative analgesics and sedagent agents. This is SCCM curated COVID-19 microlearning content.


Critical Illness, Intensive Care, And Post-Traumatic Stress Disorder

This resource is a patient guide detailing how Post-Traumatic Stress Disorder (PTSD) is seen in critical illness and intensive care. This is a community developed COVID-19 microlearning resource.


How to Maintain Wellness in the COVID-19 Era

Intensive care unit (ICU) clinicians tend to pride themselves on their ability to care for others, even if it is at the expense of taking care of themselves. Some think of this mantra of "others before me" as a badge of honor, according to James C. Jackson, PhD, PsyD, research professor and assistant director of the ICU Recovery Center at Vanderbilt University Medical Center. Dr. Jackson has a strong message to these clinicians: Now is not the time to dismiss your own needs.


SCCM Pod-418 COVID-19 Learning: Conversion of a Children's Hospital to an Adult Hospital

Montefiore Medical Center in the Bronx, New York, USA, quickly converted a children's hospital to an adult COVID-19 hospital.


SCCM Pod-417 COVID-19-Associated Acute Respiratory Distress Syndrome

Clinicians are working to understand and formulate an effective treatment for COVID-19-associated acute respiratory distress syndrome (Marini J. Crit Care Med. 2020 May 13; Epub ahead of print).


SCCM Pod-416 COVID-19 Learning: Multiple Patients on a Single Ventilator

In a situation where ventilators are in short supply, multiple patients on a single ventilator could be a strategy of last resort. In this podcast, Arthur S. Slutsky, MD, discusses his article "Personalized Ventilation to Multiple Patients Using a Single Ventilator: Description and Proof of Concept" (Han J, et al. Crit Care Explor. 2020;2:e0118).


SCCM Pod-415 NIH COVID-19 Treatment Guidelines

The National Institutes of Health has released Coronavirus Disease 2019 (COVID-19) Treatment Guidelines.


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