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Tag: Sepsis

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Association of Socioeconomic Status and Pediatric Sepsis Outcomes

Children being treated for sepsis stayed in the hospital longer if they lived in low-income ZIP codes compared to those who were from high-income ZIP codes, suggests a large national study being presented at the Society of Critical Care Medicine’s 50th Critical Care Congress.


Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis

From Critical Care Medicine.  In this article the authors present a longitudinal analysis of the immune response in coronavirus disease 2019 patients, its correlation with outcome, and comparison between severe coronavirus disease 2019 patients and septic patients. They conclude that severe coronavirus disease 2019 is associated with a unique immune profile as compared with sepsis. Several immune features are associated with outcome and suggest that immune monitoring of coronavirus disease 2019 might be helpful for patient management.


A Global Solution for Sepsis

This session was presented during the Society of Critical Care Medicine’s (SCCM) 47th Critical Care Congress. Flavia R. Machado, MD, PhD, discusses the current limitations of our knowledge of sepsis incidence and mortality rates as well as major disparities in sepsis care around the world. She proposes interventions for reducing sepsis incidence and improving sepsis outcomes worldwide.


Concise Critical Appraisal: Early Hemostatic Management of Disseminated Intravascular Coagulopathy

This Concise Critical Appraisal delves into a study published in Pediatric Critical Care Medicine that sought to determine whether early hemostatic intervention can prevent the development of DIC and improve outcomes.


Consideration of Severe Coronavirus Disease 2019 As Viral Sepsis and Potential Use of Immune Checkpoint Inhibitors

From Critical Care Explorations. Supportive treatment and immunomodulators have a critical place in the treatment of severe patients until effective antivirals are developed. Interleukin-6 antagonists, one of the immunomodulating agents, appears to be effective in the treatment of cytokine storm, but some patients continue to have severe lymphopenia and immunosuppression.


Angelica Hale: SCCM ICU Heros Award Winner

ICU Heroes Award Winner Angelica Hale performs When You Believe by Whitney Houston.


Concise Critical Appraisal: Effect of Community-Acquired Pediatric Sepsis on Survivors

Killien et al (Pediatr Crit Care Med. 2019;Epub ahead of print) set out to evaluate the prevalence of health-related quality of life (HRQL) decline in pediatric survivors of community-acquired sepsis, severe sepsis, and septic shock and to determine which factors are associated with a failure to return to baseline HRQL.


Core Outcome Measures for Trials in People With Coronavirus Disease 2019: Respiratory Failure, Multiorgan Failure, Shortness of Breath, and Recovery

From Critical Care Medicine. The authors sought to establish the core outcome measures for respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality for trials in coronavirus disease 2019.


Controversies in the Early Detection and Treatment of Sepsis

This session was presented during the Society of Critical Care Medicine’s (SCCM) 47th Critical Care Congress.


Concise Critical Appraisal: PERSEVERE Biomarkers in Predicting AKI in Pediatric Septic Shock

Can the biomarkers identified in the Pediatric Sepsis Biomarker Risk Model (PERSEVERE II) be used to predict acute kidney injury and renal recovery in pediatric septic shock? This Concise Critical Appraisal explores a study in which Stanski et al (Am J Respir Crit Care Med. 2020;201:848-855) sought to answer this question.


Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis

From Critical Care Medicine. The authors report that that majority of coronavirus disease 2019 patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction. 


Early Identification of Sepsis: The Journey Since the Sepsis on the Wards Collaborative

This article was first published in the August 2019 issue of Critical Connections. AdventHealth Shawnee Mission in Shawnee Mission, Kansas, USA, had a unique opportunity to impact the care provided to patients with sepsis in partnership with the Surviving Sepsis Campaign’s (SSC) Sepsis on the Wards Collaborative. Three years later, building on this foundation, processes are still being streamlined to improve the care of this challenging population.


Help Shape the Future of Sepsis Research on the National Level

The National Institute of General Medical Sciences (NIGMS) is changing its priorities to invest in sepsis research in a more targeted and strategic way. In an important opportunity to help shape the future of sepsis research, NIGMS has issued a request for information related to its new priorities. The request for information is found here and is due by November 15, 2019.


Editorial: Coronavirus Disease 2019: A Tsunami of Data and a Plethora of Unanswered Questions

From Pediatric Critical Care Medicine. In this editorial, the author discusses issues emerging from the study by Bhumbra et al. (Clinical features of critical coronavirus disease 2019 in children) that are worthy of discussion and further exploration, including the predilection for racial minorities, similarities and differences to sepsis, wide expression of clinical disease, and the conundrum of providing family centered care.


Pediatric Sepsis 2018

This is a presentation from the 47th Critical Care Congress on pediatric sepsis.


The Future of Sepsis Treatment

Sepsis continues to affect Americans and hospital patients across the United States. The Centers for Disease Control and Prevention (CDC) estimates that approximately 1.7 million adult Americans develop sepsis each year1; this is more than the entire population of Phoenix, the fifth-largest city in the country.2 Approximately 270,000 of these patients die from sepsis.


Editorial: Pediatric Sepsis in the Time of Coronavirus Disease 2019

From Pediatric Critical Care Medicine. In this editorial, the author reviews ""Perspectives on Pediatric Sepsis in Patients with COVID-19"" from the Surviving Sepsis Campaign Pediatric Guidelines Taskforce authors.
 


SCCM Pod-403 Sepsis: The Hour-1 Bundle, the Future of Research, and More

Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis.


Editorial: Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond

From Critical Care Medicine. This Editorial accompanies the article “Coronavirus Disease 2019 as a Cause of Viral Sepsis: A Systematic Review and Meta-Analysis” by Karakike et al.


SCCM Pod-406 Surviving Sepsis Campaign Children's Guidelines

Margaret M. Parker, MD, MCCM, and Scott L. Weiss, MD, FCCM, discuss the release of "Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children," published in the February 2020 issue of Pediatric Critical Care Medicine (Weiss S, et al. Pediatr Crit Care Med. 2020;21(2);e52-e106).


Editorial: Utility of Coronavirus Disease 2019 Immune Profiling for the Clinician at the Bedside

From Critical Care Medicine. This Editorial was written in response to the article by de Roquetaillade et al. entitled “Comparison of Circulating Immune Cells Profiles and Kinetic Between Coronavirus Disease 2019 and Bacterial Sepsis,” which explores the relationship between the immune profile of COVID-19 patients and clinical outcomes.


SCCM Pod-407 Life Following Pediatric Septic Shock

Margaret M. Parker, MD, MCCM, and Jerry J. Zimmerman, MD, PhD, FCCM, talk about the trajectory of long-term mortality and significant health-related quality of life disability among children encountering septic shock.


Foreword: Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?

From Critical Care Medicine. In this foreword, the authors contend that there should be no debate that SARS-CoV-2 is an important cause of sepsis and that labeling it as such is beneficial and appropriate.


SCCM Pod-409 SSC COVID-19 Guidelines

Explore the Surviving Sepsis Campaign's Guidelines on the Management of Critically Ill Adults with Coronavirus Disease 2019 (COVID-19) (Alhazzani W, et al. Crit Care Med. 2020 Mar 27; Epub ahead of print) with host Kyle B. Enfield, MD, and authors Mitchell M. Levy, MD, MCCM, and Waleed Alhazzani, MD, MSc, FRCPC.


How have sepsis protocols or bundles been used in COVID-19 patients and what is the best way to navigate these bundles, especially regarding fluids?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on April 14th, 2021


SCCM Pod-427 Severe COVID-19 and Sepsis

Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection. Explore the definition of sepsis and overlap with case descriptions of patients with severe COVID-19, treatment, and more. 


Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019

From Pediatric Critical Care Medicine. In this article, the authors discuss the Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children as they relate to COVID-19.


SCCM Pod-439 The Association Between Antibiotic Delay and Hospital Mortality

Explore the correlation between antibiotic delay and hospital mortality in patients with sepsis in this podcast.


Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor

From Critical Care Medicine

The authors found that procalcitonin exerts a moderate but harmful effect on disease progression in experimental septic shock, and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis.


SCCM Pod-VCCR10 Pathophysiology and Management of AKI

Richard Iuorio, MD, speaks with Kianoush Kashani, MD and Jim Reilly, MD about the pathophysiology and management of acute kidney injury.


Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C

From Critical Care Medicine

The authors invesitated the safety and efficacy of megadose sodium ascorbate in sepsis.


SCCM Pod-VCCR2 New Onset Atrial Fibrillation in Septic Shock

Sean P. Kane, PharmD, BCPS, speaks with Ishaq Lat, PharmD, about new onset atrial fibrillation in septic shock. In the epsiode, the issue of rate versus rhythm control is discussed as well as the need for anticoagulation among this patient population.


SCCM Pod-427 Severe COVID-19 and Sepsis

Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection.


SCCM Pod-VCCR6 Vasopressor Selection in Septic Shock

Sean P. Kane, PharmD, BCPS, speaks with Scott T. Benken, PharmD, BCPS-AQ Cardiology about vasopressor selection in septic shock.


Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

From Critical Care Medicine. The authors present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.
 


Sepsis Alliance

The Sepsis Alliance aims to educate the public and healthcare professionals about sepsis.


Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

From Critical Care Medicine

The authors tested and found that a previously defined bacterial sepsis endotype classifier recapitulates the same clinical and immunological endotypes in viral sepsis (coronavirus disease 2019).


Sepsis: A Threat That Needs a Global Solution

The Society of Critical Care Medicine's Critical Care Congress features internationally renowned faculty and content sessions highlighting the most up-to-date, evidence-based developments in critical care medicine. This is a presentation from the Society of Critical Care Medicine's 47th Critical Care Congress.


Sepsis: The Golden Hours; The Tipping Point

This is a presentation from the 47th Critical Care Congress on Sepsis: The Golden Hours; The Tipping Point.


Surviving Sepsis Campaign Releases First Guidelines for Sepsis in Children

This article was originally published in the Spring 2020 Issue of Critical Conectionns. The Surviving Sepsis Campaign (SCC) in February released its first guidelines for pediatric patients with sepsis, marking a new milestone in the initiative’s mission to improve sepsis care and save lives.


Surviving Sepsis Collaborative Stories

Raeann M. Fuller, CCRN, MSN, RN, CNML, and Steven Simpson, MD, discuss their experience as members of the Surviving Sepsis Campaign Collaborative.


Texas Hold 'Em: Going All In for Double Coverage of Gram-Negative Sepsis

This is a presentation from the 47th Critical Care Congress on double coverage of gram-negative sepsis. 


THRIVE: Recovery After a Hospitalization for Sepsis

Sepsis is the body’s overwhelming and life-threatening response to infection. This video offers strategies for sepsis survivors and their families