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This Concise Critical Appraisal delves into the impact of respiratory syncytial virus (RSV) and explores a recent trial that led to U.S. Food and Drug Administration approval of the first RSV vaccine. The Adult Respiratory Syncytial Virus (AReSVi-006) clinical trial is an ongoing, international, randomized, placebo-controlled trial that assesses the safety and effectiveness of a single dose of an RSV vaccine in nearly 25,000 patients.