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Untreated hyperammonemia can cause irreversible neurologic damage, coma, or death. Pamela M. Peeke, MD, MPH, FACP, FACSM, is joined by Anna-Kaisa Niemi, MD, PhD, and a patient who was hospitalized for hyperammonemia at age 8 years to discuss the importance of improved recognition of hyperammonemia and awareness of the underlying causes, such as urea cycle disorders. This podcast is sponsored by Horizon Therapeutics.