Comparison of Circulating Immune Cells Profiles and Kinetics Between Coronavirus Disease 2019 and Bacterial Sepsis

From Critical Care Medicine .  In this article the authors present a longitudinal analysis of the immune response in coronavirus disease 2019 patients, its correlation with outcome, and comparison between severe coronavirus disease 2019 patients and septic patients. They conc...

A High Neutrophil-Lymphocyte Ratio Is Associated With Increased Morbidity and Mortality in Patients With Coronavirus Disease 2019

From Critical Care Explorations .  This study aimed to evaluate the prognostic potential of admission neutrophil-lymphocyte ratio in patients admitted to the medical ICU with coronavirus disease 2019. The authors concluded that the neutrophil-lymphocyte ratio at the time of h...

A Multicenter Evaluation of Survival After In-Hospital Cardiac Arrest in Coronavirus Disease 2019 Patients

From Critical Care Explorations .  In-hospital cardiac arrest survival among coronavirus disease 2019 patients has been reported to range from 0% to 12% -- significantly lower than reported prepandemic in-hospital cardiac arrest survival rates of approximately 20% to 25% in t...

Letter to the Editor: Cytokine Blockade in Coronavirus Disease 2019: Keeping an Open Mind

From Critical Care Explorations .  This Letter to the Editor was written in response to the article by Rizvi and Gallo De Moraes entitled “New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade.”

Timing of Intubation in Coronavirus Disease 2019: A Study of Ventilator Mechanics, Imaging, Findings, and Outcomes

From Critical Care Explorations  The authors sought to determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.

Characteristics, Comorbidities, Complications, and Outcomes Among 802 Patients With Severe Acute Respiratory Syndrome Coronavirus 2 in a Community Hospital in Florida

From Critical Care Explorations .  In this study, the authors reviewed the demographics, characteristics, comorbidities, complications, and outcomes of hospitalized patients with severe acute respiratory syndrome coronavirus 2, and their association with mortality at medical ...

Coronavirus Disease 2019–Associated PICU Admissions: A Report From the Society of Critical Care Medicine Discovery Network Viral Infection and Respiratory Illness Universal Study Registry

From Pediatric Critical Care Medicine . This study delineates significant clinically relevant differences in presentation, explanatory factors, and outcomes among children admitted to PICU with severe acute respiratory syndrome coronavirus 2–related illness stratified by mult...

Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis

From Critical Care Medicine . In this systematic review and meta-analysis, the authors found that, despite the significant variability in frequency and duration of prone positioning and respiratory supports applied, prone positioning was associated with improvement in oxygena...

Letter to the Editor: Bias Due to Cohort Construction in the Study of Timing of Invasive Ventilation

From Critical Care Explorations . In this Letter to the Editor, the authors respond to an article by Dupuis et al., congratulating the contribution to the problem of identifying which patients with hypoxemic respiratory failure truly benefit from invasive ventilation and sugg...

Determining Cause of Death During Coronavirus Disease 2019 Pandemic

From Critical Care Explorations . In this single-center study, the authors found that the majority of deaths in severe acute respiratory syndrome coronavirus 2–positive hospitalized patients were related to a typical or atypical presentation of coronavirus disease 2019 disease.

Frugal Innovation: Enabling Mechanical Ventilation During Coronavirus Disease 2019 Pandemic in Resource-Limited Settings

From Critical Care Explorations . In this commentary, the authors note that low-quality care has become a greater determinant of mortality than lack of access. To address this, they suggest a systems-wide approach to improving the quality of mechanical ventilation in resource...

Existing Crisis Standards of Care Triage Protocols May Not Significantly Differentiate Between Patients With Coronavirus Disease 2019 Who Require Intensive Care

From Critical Care Explorations . The authors sought to determine how several existing crisis standards of care triage protocols would have distinguished between patients with coronavirus disease 2019 requiring intensive care.

Editorial: Convalescent Plasma and Coronavirus Disease 2019: Time for Reassessment

From Critical Care Medicine . In this Editorial, the wonder if the use of convalescent plasma needs to be further whittled to an even smaller subset of patients and ultimately whether there is even a practical role for this therapy in the treatment of COVID-19 particularly in...

Online Letter to the Editor: Understanding the Underlying Mechanisms of Hyponatremia in Coronavirus Disease 2019 Is Critical Since Treatment Varies Based on Etiology: Let Us Not Forget Critical Illness-Related Corticosteroid Insufficiency As the Treatment

From Critical Care Medicine. In this Online Letter to the Editor, the authors write in response to an article by Frontera et al. in Critical Care Medicine about etiology of hyponatremia in coronavirus disease 2019 (COVID-19) patients.

Acute Cardiac Injury in Coronavirus Disease 2019 and Other Viral Infections—A Systematic Review and Meta-Analysis

From Critical Care Medicine . In this review article, the authors compared the rates of cardiac injury by angiotensin converting enzyme-2–binding viruses from viruses that do not bind to angiotensin-converting enzyme-2.

Severe Acute Respiratory Syndrome Coronavirus 2 Convalescent Plasma Versus Standard Plasma in Coronavirus Disease 2019 Infected Hospitalized Patients in New York: A Double-Blind Randomized Trial

From Critical Care Medicine . In this study, the authors found that administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated wi...

Letter to the Editor: Outcomes and Safety of Early Percutaneous Tracheostomy in Coronavirus Disease 2019 Patients Admitted to the ICU

From Critical Care Medicine . This letter to the editor was written in response to "Early Percutaneous Tracheostomy in Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 12...

Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation–Adjusted Mortality and Length of Stay Than Viral Pneumonia ICU Patients

From Critical Care Medicine . The authors compared APACHE-IV–adjusted mortality and length of stay outcomes of adult ICU patients who tested positive for coronavirus disease 2019 with patients admitted to ICU with other viral pneumonias.

Coronavirus Disease 2019 Policy Restricting Family Presence May Have Delayed End-of-Life Decisions for Critically Ill Patients

From Critical Care Medicine . The authors investigate if a restrictive visitor policy inadvertently lengthened the decision making process for dying inpatients without coronavirus disease 2019.

Editorial: Capacity Strain and Response During Coronavirus Disease 2019: One Size Does Not Fit All, and One Size Does Not Fit One

From Critical Care Medicine . In this editorials, the authors discuss hospital preparedness in the article "Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic."