How have sepsis protocols or bundles been used in COVID-19 patients and what is the best way to navigate these bundles, especially regarding fluids?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on April 14th, 2021

Procalcitonin Exerts a Mediator Role in Septic Shock Through the Calcitonin Gene-Related Peptide Receptor

From Critical Care Medicine The authors found that procalcitonin exerts a moderate but harmful effect on disease progression in experimental septic shock, and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis.

Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus Disease 2019

From Critical Care Medicine The authors tested and found that a previously defined bacterial sepsis endotype classifier recapitulates the same clinical and immunological endotypes in viral sepsis (coronavirus disease 2019).

Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C

From Critical Care Medicine The authors invesitated the safety and efficacy of megadose sodium ascorbate in sepsis.

SCCM Pod-427 Severe COVID-19 and Sepsis

Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection.

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

From Critical Care Medicine . The authors present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.  

Foreword: Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?

From Critical Care Medicine . In this foreword, the authors contend that there should be no debate that SARS-CoV-2 is an important cause of sepsis and that labeling it as such is beneficial and appropriate.

Editorial: Pediatric Sepsis in the Time of Coronavirus Disease 2019

From Pediatric Critical Care Medicine.  In this editorial, the author reviews ""Perspectives on Pediatric Sepsis in Patients with COVID-19"" from the Surviving Sepsis Campaign Pediatric Guidelines Taskforce authors.  

Perspective of the Surviving Sepsis Campaign on the Management of Pediatric Sepsis in the Era of Coronavirus Disease 2019

From Pediatric Critical Care Medicine. In this article, the authors discuss the Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children as they relate to COVID-19.

Is there a relationship between the development of sepsis, the development of COVID-19, and subsequent mortality?

Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered.