Health Worker Burnout

On May 23, United States Surgeon General Dr. Vivek Murthy issued a new advisory, the Surgeon General’s Advisory Addressing Health Worker Burnout, highlighting the urgent need to address the health worker burnout crisis across the country. This advisory details recommendations ...

​​COVID-19 Therapeutics Thr​esholds, Orders, and Replenishment by Jurisdiction

On April 25, 2022, the distribution process for COVID-19 therapeutics to state and territorial health departments transitioned from the previous allocation process to one that more closely aligns with the allocation and ordering process for vaccines. 

CDC Resources: Neurology

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Neurology

NIH Resource: Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications

Ritonavir, a strong cytochrome P450 (CYP) 3A4 inhibitor and a P-glycoprotein inhibitor, is coadministered with nirmatrelvir to increase the blood concentration of nirmatrelvir, thereby making it effective against SARS-CoV-2. Ritonavir may also increase blood concentrations of ...

New Paxlovid Dose Pack Author​ized by FDA

On April 14, 2022, the FDA revised the Emergency Use Authorization (EUA) for the COVID-19 oral antiviral therapeutic Paxlovid to authorize an additional dose pack presentation with appropriate dosing for patients with moderate renal impairment within the scope of the EUA. As a...

Post-ICU COVID-19 Clinics

Post-ICU COVID-19 clinics are newly established programs providing care for patients with post-intensive care syndrome (PICS) related to COVID-19. During this webcast, subject matter experts discussed how post-ICU COVID-19 clinics developed with an interdisciplinary model impr...

Characteristics of Post-ICU and Post-COVID Recovery Clinics in 29 U.S. Health Systems

From Critical Care Explorations The authors describe the structure and process characteristics of existing and newly implemented ICU-RCs and COVID-RCs in a subset of large health systems in the United States.

Increasing Mortality in Venovenous Extracorporeal Membrane Oxygenation for COVID-19–Associated Acute Respiratory Distress Syndrome

From Critical Care Explorations The authors determine the factors associated with mortality in venovenous extracorporeal membrane oxygenation (V-V ECMO) patients with COVID-19 infection and provide an updated report of clinical outcomes for patients treated with V-V ECMO for C...

Albumin Kinetics in Sepsis and COVID-19

From Critical Care Explorations In this Letter to the Editor the authors concluded that the pattern of albumin kinetics may be predictive of outcome in COVID-19 and sepsis-induced ARDS.

The Third Wave: Comparing Seasonal Trends in COVID-19 Patient Data at a Large Hospital System in New York City

From Critical Care Explorations The authors compare the demographics and outcomes of hospitalized patients during New York City’s third wave of COVID-19 to the first two waves.

Airway Pressure Release Ventilation in Acute Respiratory Failure Due to COVID-19: When One Door Closes

From Critical Care Medicine In this Letter to the Editor the authors write in reponse to Ibarra-Estrada et al. 

Letters to the Editor: The authors reply to Etiopathogenetic Particularities and Prognostic Impact of Right Ventricular Involvement in COVID-19–Related Acute Respiratory Distress Syndrome

From Critical Care Medicine In this Letter to the Editor the authors respond to Dandel et al. 

Etiopathogenetic Particularities and Prognostic Impact of Right Ventricular Involvement in COVID-19–Related Acute Respiratory Distress Syndrome

From Critical Care Medicine In this Letter to the Editor the authors write in response to Chotalia et al. 

Letters to the Editor: The authors reply to Phenotypic Characterization of Right Ventricular Dysfunction and Prognostication in COVID-19-Induced Acute Respiratory Distress

From Critical Care Medicine In this Letter to the Editor the authors respond to Jha et al. 

Phenotypic Characterization of Right Ventricular Dysfunction and Prognostication in COVID-19–Induced Acute Respiratory Distress Syndrome

From Critical Care Medicine In this Letter to the Editor the authors write in reponse to Chotalia et al. 

Influence of Geopolitics on Severity and Outcome in COVID-19*

From Critical Care Medicine In this Editorial the authors write an accompanying piece to Mesotten et al. 

Prone Position in COVID-19 and -COVID-19 Acute Respiratory Distress Syndrome: An International Multicenter Observational Comparative Study*

From Critical Care Medicine The authors quantify the response to prone position, describe the differences between coronavirus disease 2019 acute respiratory distress syndrome and acute respiratory distress syndrome, and explore variables associated with survival.

Differences and Similarities Among COVID-19 Patients Treated in Seven ICUs in Three Countries Within One Region: An Observational Cohort Study*

From Critical Care Medicine The authors investigated healthcare system–driven variation in general characteristics, interventions, and outcomes in coronavirus disease 2019 (COVID-19) patients admitted to the ICU.

WHO resource: WHO updates its treatment guidelines to include molnupiravir

WHO has updated its living guidelines on COVID-19 therapeutics to include a conditional recommendation on molnupiravir, a new antiviral medicine. This is the first oral antiviral drug to be included in the treatment guidelines for COVID-19. As this is a new medicine, there ...

Fact Sheet: COVID-19 Test to Treat

Through this program, people are able to get tested and – if they are positive and treatments are appropriate for them – receive a prescription from a health care provider, and have their prescription filled all at one location. These “One-Stop Test to Treat” sites are availab...