Impaired Microvascular Function in Patients With Critical COVID-19

From Critical Care Explorations The authors investigate microvascular function in patients with critical coronavirus disease 2019.

Coronavirus Disease 2019 Temperature Trajectories Correlate With Hyperinflammatory and Hypercoagulable Subphenotypes

From Critical Care Medicine The authors determined the association between temperature trajectories and distinct manifestations of coronavirus disease 2019.

Multisystem Inflammation and Organ Dysfunction After BNT162b2 Messenger RNA Coronavirus Disease 2019 Vaccination

From Critical Care Explorations  While the overall safety profile of the BNT162b2 coronavirus disease 2019 vaccine remains excellent for the general population, rare serious events have been reported. In this case report, the authors describe a case of multisystem inflammation...

Barotrauma in Coronavirus Disease 2019 Patients Undergoing Invasive Mechanical Ventilation: A Systematic Literature Review

From Critical Care Medicine . In this Review Article the authors performed a systematic literature review to identify rates of barotrauma, pneumothorax, and pneumomediastinum in coronavirus disease 2019 acute respiratory distress syndrome patients receiving invasive mechanica...

Letter to the Editor: Bias Due to Cohort Construction in the Study of Timing of Invasive Ventilation

From Critical Care Explorations . In this Letter to the Editor, the authors respond to an article by Dupuis et al., congratulating the contribution to the problem of identifying which patients with hypoxemic respiratory failure truly benefit from invasive ventilation and sugg...

Surviving Sepsis Campaign: Research Priorities for Coronavirus Disease 2019 in Critical Illness

From Critical Care Medicine .  In this article, the authors identify research priorities that represent a roadmap for investigation in COVID-19. 

CDC Resources: Research

SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Research

Harmonizing Heterogeneous Endpoints in Coronavirus Disease 2019 Trials Without Loss of Information

From Critical Care Medicine The authors aim to provide hands-on statistical guidelines for harmonizing heterogeneous endpoints in coronavirus disease 2019 clinical trials.

Camostat Mesylate May Reduce Severity of Coronavirus Disease 2019 Sepsis: A First Observation

From Critical Care Explorations The authors present a case series of eleven patients, five treated with camostat mesylate and six treated with hydroxychloroquine.

A Propensity-Matched Cohort Study of Tocilizumab in Patients With Coronavirus Disease 2019

From Critical Care Explorations The authors assessed the impact of tocilizumab therapy and found that it was associated with significantly improved survival in coronavirus disease 2019 patients.

Intravenous Immunoglobulin Plus Methylprednisolone Mitigate Respiratory Morbidity in Coronavirus Disease 2019

From Critical Care Explorations The authors piloted a randomized trial of IV immunoglobulin in coronavirus disease 2019 patients and found significantly improved hypoxia and reduced hospital length of stay.

Online Letter to the Editor: Analysis of Critical Care Severity of Illness Scoring Systems in Patients With Coronavirus Disease 2019: A Retrospective Analysis of Three U.K. ICUs

From Critical Care Medicine In this letter, the authors discuss APACHE II scores being used to predict mortality in coronavirus disease 2019 patients, however it may not be replicable.

Prognostic Factors for 30-Day Mortality in Critically Ill Patients With Coronavirus Disease 2019: An Observational Cohort Study

From Critical Care Medicine The authors identified patient characteristics that predict an increased likelihood of death within 30 days of the start of critical care for patients with coronavirus disease 2019, which included age, ethnicity, deprivation, body mass index, an...

Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry

From Critical Care Medicine.  In this article, the authors describe how the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study coronavirus disease 2019 registry sought to develop and implement prespecified best practices combin...

Evaluation of the Risk Prediction Tools for Patients With Coronavirus Disease 2019 in Wuhan, China: A Single-Centered, Retrospective, Observational Study

From Critical Care Medicine. In this study from China, the authors evaluated and compared the efficacy of National Early Warning Score, National Early Warning Score 2, Rapid Emergency Medicine Score, Confusion, Respiratory rate, Blood pressure, Age 65 score, and quick Sepsis-r...

Principles Guiding Nonpandemic Critical Care Research During a Pandemic

From Critical Care Medicine. In this article, the authors describe the importance of critical care clinical research that is not pandemic-focused during pandemic times; outline principles to assist in the prioritization of nonpandemic research during pandemic times; and propos...

Core Outcomes Set for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The authors aimed to establish a core outcomes set for trials in people with suspected or confirmed coronavirus disease 2019.

International Survey to Establish Prioritized Outcomes for Trials in People With Coronavirus Disease 2019

From Critical Care Medicine. The author set out to generate a consensus-based, prioritized list of outcomes for coronavirus disease 2019 trials.

Leveraging Tele-Critical Care Capabilities for Clinical Trial Consent

From Critical Care Explorations. In this article, the authors share their experience with a patient with severe COVID-19 who was admitted to a clinical trial of an investigational COVID-19 therapeutic using video-telecommunication to obtain informed consent.

Letter to the Editor: Factors Associated With Pulmonary Embolism Among Coronavirus Disease 2019 Acute Respiratory Distress Syndrome

From Critical Care Explorations. To do better understand the risk factors associated with pulmonary embolism in patients with COVID-19, the authors performed a post hoc analysis from the COVADIS project, a multicenter observational study gathering 21 ICUs from France and Belgium.