Online Letter to the Editor: Coronavirus Disease-Induced Blurred Judgment

From Critical Care Medicine . This Online Letter to the Editor was written in response to the article by Alhazzani et al. entitled “Surviving Sepsis Campaign Guidelines on the Management of Adults With Coronavirus Disease 2019 (COVID-19) in the ICU: First Update.”

Editorial: Severe COVID-19 and Stroke—Another Piece in the Puzzle

From Critical Care Medicine . In this Editorial, the authors discuss an article by Cho et al. entitled “Ischemic and hemorrhagic stroke among critically ill patients with coronavirus disease 2019: An international multicenter coronavirus disease 2019 critical care consortium ...

Online Letter to the Editor: The Limitations of Standardized Mortality Ratios for Coronavirus Disease 2019 ICU Patients

From Critical Care Medicine . In this Online Letter to the Editor, the authors discuss the article by Higgins et al. entitled “Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation-Adjusted Mortality and Length of Stay ...

Natriuretic Peptide Levels and Clinical Outcomes Among Patients Hospitalized With Coronavirus Disease 2019 Infection

From Critical Care Explorations . In this study, the authors hypothesized that pro-B-type natriuretic peptide level would be associated with mortality and clinical outcomes in hospitalized coronavirus disease 2019 patients.

Methylprednisolone and 60 Days in Hospital Survival in Coronavirus Disease 2019 Pneumonia

From Critical Care Explorations . In this study, the authors found that low-dose methylprednisolone was associated with reduced mortality if given greater than 7 days from onset of symptoms, and no additional benefit greater than 14 days; high dose was associated with higher ...

Long-Term Acute Care Hospital Outcomes of Mechanically Ventilated Patients With Coronavirus Disease 2019

From Critical Care Medicine . In this study, the authors reported that most patients with coronavirus disease 2019 transferred to two Chicago-area long-term acute care hospitals successfully weaned from prolonged mechanical ventilation.

Mortality Among Noncoronavirus Disease 2019 Critically Ill Patients Attributable to the Pandemic in France

From Critical Care Medicine . In this study, the authors found that in hospital units with moderate or high levels of coronavirus disease 2019 critically ill patients, noncoronavirus disease deaths were at higher levels.

Body Mass Index and Mortality in Coronavirus Disease 2019 and Other Diseases: A Cohort Study in 35,506 ICU Patients

From Critical Care Medicine . The authors concluded that, the obesity paradox, which is the inverse J-shaped association between BMI and mortality in critically ill patients, is not present in critically ill patients with COVID-19–related respiratory failure in contrast to no...

Ischemic and Hemorrhagic Stroke Among Critically Ill Patients With Coronavirus Disease 2019: An International Multicenter Coronavirus Disease 2019 Critical Care Consortium Study

From Critical Care Medicine . In an international registry of ICU patients with coronavirus disease 2019, stroke was infrequent. Hemorrhagic stroke, but not ischemic stroke, was associated with increased mortality. Further, both hemorrhagic stroke and ischemic stroke were ass...

Trends in ICU Mortality From Coronavirus Disease 2019: A Tale of Three Surges

From Critical Care Medicine . The authors sought to determine the association between time period of hospitalization and hospital mortality among critically ill adults with coronavirus disease 2019.

Editorial: The Role of the Long-Term Acute Care Hospital Following Critical Illness—Has the Coronavirus Disease 2019 Pandemic Demonstrated Their Usefulness or Emphasized Their Downside?

From Critical Care Medicine . This Editorial accompanies the article “Long-Term Acute Care Hospital Outcomes of Mechanically Ventilated Patients With Coronavirus Disease 2019’ by Saad et al.

Editorial: Quantifying the Burden of Viral Sepsis During the Coronavirus Disease 2019 Pandemic and Beyond

From Critical Care Medicine . This Editorial accompanies the article “Coronavirus Disease 2019 as a Cause of Viral Sepsis: A Systematic Review and Meta-Analysis” by Karakike et al.

Coronavirus Disease 2019 as Cause of Viral Sepsis: A Systematic Review and Meta-Analysis

From Critical Care Medicine . The authors report that that majority of coronavirus disease 2019 patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction. 

Trends in 28-Day Mortality of Critical Care Patients With Coronavirus Disease 2019 in United Kingdom: A National Cohort Study, March 2020 to January 2021

From Critical Care Medicine . The authors sought to determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United K...

Awake Venovenous Extracorporeal Membrane Oxygenation for Coronavirus Disease 2019 Acute Respiratory Failure

From Critical Care Explorations . This report demonstrates that in a selected group of patients, an “awake” venovenous extracorporeal membrane oxygenation approach is feasible and may result in favorable outcomes.

Empirical Assessment of U.S. Coronavirus Disease 2019 Crisis Standards of Care Guidelines

From Critical Care Explorations.  The authors found that this proof-of-principle study demonstrates the feasibility and importance of empirical testing of crisis standards of care guidelines to understand whether they meet their goals.

Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case Report

From Critical Care Explorations . Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case ReportG966

Pharmacotherapy in Coronavirus Disease 2019 and Risk of Secondary Infections: A Single-Center Case Series and Narrative Review

From Critical Care Explorations . The authors sought to evaluate the impact of pharmacologic approach to coronavirus disease 2019 within the ICU on secondary infections and clinical outcomes.

Performance Analysis of the National Early Warning Score and Modified Early Warning Score in the Adaptive COVID-19 Treatment Trial Cohort

From Critical Care Explorations .  In this study, the authors sought to validate prognostic scores in coronavirus disease 2019 including National Early Warning Score, Modified Early Warning Score, and age-based modifications, and define their performance characteristics.

Cardiopulmonary Exercise Testing in Critically Ill Coronavirus Disease 2019 Survivors: Evidence of a Sustained Exercise Intolerance and Hypermetabolism

From Critical Care Explorations .  In this study, the authors found prolonged reduced exercise capacity up to 6 months in critically ill coronavirus disease 2019 survivors. This disability did not result from residual pulmonary or cardiac dysfunction but rather from a metabol...