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Content Type: Articles

Letter to the Editor: Urinary Neutrophil Gelatinase-Associated Lipocalin in Critically Ill Patients With Coronavirus Disease 2019

From Critical Care Explorations . In this Letter to the Editor, the authors report a retrospective analysis of urinary neutrophil gelatinase-associated lipocalin (NGAL) in ICU patients with COVID-19-associated respiratory failure.   

   Estimated Time: 8:27 AKI/Renal, Coronavirus, COVID-19

Letter to the Editor: The Triage Stalemate During the Coronavirus Disease 2019 Pandemic: Losing Fairness to Ethical Paralysis

From Critical Care Medicine . The authors write in response to an article in Critical Care Medicine by Sprung et al., which outlined the major considerations for ethical ICU triaging under pandemic conditions and discuss the lack of systematic triaging in U.S. health care ins...

   Estimated Time: 8:32 Coronavirus, COVID-19, Triage

Sepsis and Coronavirus Disease 2019: Common Features and Anti-Inflammatory Therapeutic Approaches

From Critical Care Medicine . The authors present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.  

   Estimated Time: 13:08 Coronavirus, COVID-19, Sepsis, Therapies

High-Flow Nasal Oxygen in Coronavirus Disease 2019 Patients With Acute Hypoxemic Respiratory Failure: A Multicenter, Retrospective Cohort Study

From Critical Care Medicine . In this study, the authors analyzed the effectiveness of high-flow nasal oxygen treatment and aimed to identify the variables predicting high-flow nasal oxygen treatment failure in coronavirus disease 2019 patients with acute hypoxemic respirator...

   Estimated Time: 24:00 ARDS, Coronavirus, COVID-19

Prevalence and Impact of Hyponatremia in Patients With Coronavirus Disease 2019 in New York City

From Critical Care Medicine.  In this study from New York, NY, the authors found that hyponatremia occurred in nearly a third of coronavirus disease 2019 patients, was an independent predictor of in-hospital mortality, and was associated with increased risk of encephalopathy ...

   Estimated Time: 20:14 Coronavirus, COVID-19

Foreword: Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?

From Critical Care Medicine . In this foreword, the authors contend that there should be no debate that SARS-CoV-2 is an important cause of sepsis and that labeling it as such is beneficial and appropriate.

   Estimated Time: 8:58 ARDS, Coronavirus, COVID-19, Sepsis

Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection

From Critical Care Medicine . In this single center study, the authors found that plasma exchange mitigates cytokine storm, reverses organ failure, and could improve survival in critically ill patients with coronavirus disease 2019 infection.  

   Estimated Time: 14:24 Coronavirus, COVID-19, Therapies

Endothelial Injury and Glycocalyx Degradation in Critically Ill Coronavirus Disease 2019 Patients: Implications for Microvascular Platelet Aggregation

From Critical Care Explorations . The authors found that thrombosis profiling identified endothelial activation and glycocalyx degradation in coronavirus disease 2019 positive patients and believe that the data from this study suggest that medications to protect and/or restor...

   Estimated Time: 29:59 Coronavirus, COVID-19, Diagnosis and Testing, Therapies

Editorial: Pediatric Sepsis in the Time of Coronavirus Disease 2019

From Pediatric Critical Care Medicine.  In this editorial, the author reviews ""Perspectives on Pediatric Sepsis in Patients with COVID-19"" from the Surviving Sepsis Campaign Pediatric Guidelines Taskforce authors.  

   Estimated Time: 6:39 Coronavirus, COVID-19, pediatrics, Sepsis

Does Pulmonary Aspergillosis Complicate Coronavirus Disease 2019?

From Critical Care Explorations . In this article, the authors summarize what is known about coronavirus disease 2019 complicated by Aspergillus, introduces coronavirus disease 2019–associated pulmonary aspergillosis as a possible clinical entity, and describes reasons clinic...

   Estimated Time: 14:47 Coronavirus, COVID-19, Virology

Thromboelastography to Detect Hypercoagulability and Reduced Fibrinolysis in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome Patients

From Critical Care Explorations . In this study, the authors investigated thromboelastography in patients with coronavirus disease 2019-associated acute respiratory distress syndrome with the goal of characterizing suspected coagulopathy and impaired fibrinolysis.  

   Estimated Time: 10:34 Coronavirus, COVID-19, Diagnosis and Testing

Disseminated Multifocal Intracerebral Bleeding Events in Three Coronavirus Disease 2019 Patients on Extracorporeal Membrane Oxygenation As Rescue Therapy

From Critical Care Explorations.  In this article, the authors describe three coronavirus disease 2019 patients suffering from acute respiratory distress syndrome under venovenous extracorporeal membrane oxygenation therapy and tight anticoagulation monitoring presenting a no...

   Estimated Time: 9:00 ARDS, Coronavirus, COVID-19, ECMO

Letter to the Editor: Transforming a PICU Into an Adult ICU During the Coronavirus Disease 2019 Pandemic: Meeting Multiple Needs

From Critical Care Explorations . In this Letter to the Editor, the authors describe the process converting half of their 40-bed PICU into a negative-pressure biocontainment ICU dedicated to adult coronavirus disease 2019 patients within a 1,003-bed academic quaternary hospital.

Probative Value of the D-Dimer Assay for Diagnosis of Deep Venous Thrombosis in the Coronavirus Disease 2019 Syndrome

From Critical Care Medicine. The authors describe the predictive utility of the D-dimer assay among patients with the coronavirus disease 2019 syndrome for unprovoked lower extremity deep venous thrombosis.

   Estimated Time: 13:04 Coronavirus, COVID-19, Diagnosis and Testing

Editorial: Coronavirus Disease 2019 Prediction Modeling: Everything Old Is NEWS Again

From Critical Care Medicine . In this Editorial, the authors comment on the article by Liu et al. “Evaluation of the Risk Prediction Tools for Patients With Coronavirus Disease 2019 in Wuhan, China: A Single-Centered, Retrospective, Observational Study” and note that tools de...

   Estimated Time: 7:25 Coronavirus, COVID-19

Effects of Positive End-Expiratory Pressure in “High Compliance” Severe Acute Respiratory Syndrome Coronavirus 2 Acute Respiratory Distress Syndrome

From Critical Care Medicine.  In this study, the authors state their data suggest that a ""higher” positive end-expiratory pressure approach in patients with severe acute respiratory syndrome coronavirus 2 acute respiratory distress syndrome and high compliance improves oxyge...

   Estimated Time: 13:20 ARDS, Coronavirus, COVID-19, Therapies

Placenta-Derived Cell Therapy to Treat Patients With Respiratory Failure Due to Coronavirus Disease 2019

From Critical Care Explorations . The authors sought to determinewhether placental cell therapy PLacental eXpanded (PLX)-PAD (Pluristem Therapeutics, Haifa, Israel) was beneficial to treating critically ill patients suffering from acute respiratory distress syndrome due to co...

   Estimated Time: 24:18 ARDS, Coronavirus, COVID-19, Therapies

Tokyo and New York: A Study in the Contrasting Effects of Socioeconomic Status on Coronavirus Disease 2019 Outcomes

From Critical Care Explorations.  The authors examined the association between socioeconomic status and the rate of coronavirus disease 2019 infections using public data from Tokyo.

   Estimated Time: 9:57 Coronavirus, COVID-19, Infection Control, Statistics

Editorial: Delivering Care From an Unstable Evidence Base: The Evolving Care of Coronavirus Disease 2019 Through the Lens of High-Flow Nasal Oxygen

From Critical Care Medicine.  In this Editorial, the authors discuss the challenges of caring for patients with COVID-19 without evidence to guide them through the lens of high-flow nasal oxygenation and how there have been slow changes for improvement.

   Estimated Time: 9:57 Coronavirus, COVID-19, Therapies, Ventilatory Support

Guiding Principles for the Conduct of Observational Critical Care Research for Coronavirus Disease 2019 Pandemics and Beyond: The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study Registry

From Critical Care Medicine.  In this article, the authors describe how the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study coronavirus disease 2019 registry sought to develop and implement prespecified best practices combin...

   Estimated Time: 22:22 Coronavirus, COVID-19, Statistics