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Content Type: Articles

The Use of High-Flow Nasal Oxygen in the ICU as a First-Line Therapy for Acute Hypoxemic Respiratory Failure Secondary to Coronavirus Disease 2019

From Critical Care Explorations The authors characterize outcomes associated with high-flow nasal oxygen use in critically ill adult patients with coronavirus disease 2019-associated acute hypoxemic respiratory failure.

   Estimated Time: 21:44 Coronavirus, COVID-19, Therapies

The Ties That Bind: A Coronavirus Disease Journey

From Critical Care Explorations In this article, the authors describe a personal experience of COVID-19 bringing two old friends together and the patient care lessons learned.

   Estimated Time: 05:36 Coronavirus, COVID-19, Delirium

Evaluation of the Efficacy and Safety of Inhaled Epoprostenol and Inhaled Nitric Oxide for Refractory Hypoxemia in Patients With Coronavirus Disease 2019

From Critical Care Explorations In this study, the authors evaluated the efficacy and safety of inhaled epoprostenol and inhaled nitric oxide in patients with refractory hypoxemia secondary to coronavirus disease 2019.

   Estimated Time: 25:58 Coronavirus, COVID-19, Therapies

Spectrum of Vascular Involvement in Coronavirus Disease 2019 Pneumonia—Findings on CT Perfusion

From Critical Care Explorations In this article, the authors observed and interpreted CT perfusion patterns of COVID-19 pulmonary features.

   Estimated Time: 12:46 Coronavirus, COVID-19, Diagnosis and Testing

Timing of Intubation and In-Hospital Mortality in Patients With Coronavirus Disease 2019

From Critical Care Explorations The authors examined whether increasing time between admission and intubation was associated with mortality in patients with coronavirus disease 2019 who underwent mechanical ventilation.

   Estimated Time: 24:46 Coronavirus, COVID-19, Ventilatory Support

Metabolomics Profiling of Critically Ill Coronavirus Disease 2019 Patients: Identification of Diagnostic and Prognostic Biomarkers

From Critical Care Explorations The authors performed metabolomics profiling of critically ill coronavirus disease 2019 patients to understand better the underlying pathologic processes and pathways, and to identify potential diagnostic/prognostic biomarkers.

   Estimated Time: 28:23 Coronavirus, COVID-19, Diagnosis and Testing

Resolution of Coronavirus Disease 2019 Infection and Pulmonary Pathology With Nebulized DAS181: A Pilot Study

From Critical Care Explorations The authors investigated the safety and effects of nebulized DAS181 on hypoxic coronavirus disease 2019 patients.

   Estimated Time: 15:50 Coronavirus, COVID-19, Therapies

Benchmarking Critical Care Well-Being: Before and After the Coronavirus Disease 2019 Pandemic

From Critical Care Explorations The authors examined the impact of COVID-19 with regard to well-being, measured as burnout and professional fulfillment, across critical care healthcare professionals, ICUs, and hospitals within a health system.

   Estimated Time: 25:54 Coronavirus, COVID-19

Volatile Isoflurane in Critically Ill Coronavirus Disease 2019 Patients—A Case Series and Systematic Review

From Critical Care Explorations The authors evalute the use of isoflurane in patients with coronavirus disease 2019–induced acute respiratory distress syndrome.

   Estimated Time: 22:23 min ARDS, Coronavirus, COVID-19, Therapies, Ventilatory Support

Almitrine Infusion in Severe Acute Respiratory Syndrome Coronavirus 2-Induced Acute Respiratory Distress Syndrome: A Single-Center Observational Study

From Critical Care Medicine The authors assessed the effect of almitrine, a selective pulmonary vasoconstrictor, on arterial oxygenation in severe acute respiratory syndrome coronavirus 2-induced acute respiratory distress syndrome.

   Estimated Time: 20:07 min ARDS, Coronavirus, COVID-19, Therapies

Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest?

From Critical Care Medicine The authors describe the characteristics and outcomes of in-hospital cardiac arrest in coronavirus disease 2019 patients in rural Southwest Georgia.

   Estimated Time: 19:45 min Cardiovascular, Coronavirus, COVID-19

Letter to the Editor: Clinical Risk Prediction Scores in Coronavirus Disease 2019: Beware of Low Validity and Clinical Utility

From Critical Care Explorations In this Letter to the Editor, the authors discuss their study and how their results show that the early tools developed in a relatively small, homogenous patient population are unlikely to be clinically useful in different settings.

   Estimated Time: 13:37 min Coronavirus, COVID-19, Risk Stratification

Rapid Implementation of Telecritical Care Support During a Pandemic: Lessons Learned During the Coronavirus Disease 2020 Surge in New York City

From Critical Care Explorations The authors describe key elements for a New York City health system to rapidly implement telecritical care consultative services to a newly created ICU during the coronavirus disease 2020 patient surge.

   Estimated Time: 15:33 Coronavirus, COVID-19, Telemedicine

Corticosteroid Responsive Encephalopathy: Prolonged Coma in Patients Late in the Course of Dreadful Severe Acute Respiratory Syndrome Coronavirus 2 Infection

From Critical Care Explorations. In this case report, the authors describe two cases of prolonged coma after weaning off sedation in severe acute respiratory syndrome coronavirus 2 with rapid neurologic improvement shortly after high-dose corticosteroid regimen.

   Estimated Time: 08:33 min Case Presentations, Coronavirus, COVID-19, Sedation

Acute Kidney Injury in Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus-2 Pandemic: Experience From PICUs Across United Kingdom

From Critical Care Medicine. The authors evaluated the prevalence, evolution, and clinical factors associated with acute kidney injury in children admitted to PICUs with pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome co...

   Estimated Time: 31:01 min Coronavirus, COVID-19, Renal

A Hybrid Model of Pediatric and Adult Critical Care During the Coronavirus Disease 2019 Surge: The Experience of Two Tertiary Hospitals in London and New York

From Pediatric Critical Care Medicine. In this report, the authors describe the hybrid model implemented at institutions in New York and London and discuss shared experiences, pitfalls, challenges, and adjustments required in caring for both young and older patients.

   Estimated Time: 21:49 min Coronavirus, COVID-19, pediatrics

Extracorporeal Membrane Oxygenation in Severe Acute Respiratory Distress Syndrome: Possible Late Indication for Coronavirus Disease 2019?

From Critical Care Explorations. In this case report, the authors note that late extracorporeal membrane oxygenation may be considered in selected patients as a bridge to recovery. Further prospective studies are, however, needed.

   Estimated Time: 09:23 min Case Presentations, Coronavirus, COVID-19, ECMO

Timing of Intubation and Its Implications on Outcomes in Critically Ill Patients With Coronavirus Disease 2019 Infection

From Critical Care Explorations. In this Letter to the Editor, the authors report their findings from an observational study aimed to compare the difference in outcomes of critically ill patients with coronavirus disease 2019 who were intubated early versus later in the diseas...

   Estimated Time: 12:19 min Coronavirus, COVID-19, Supportive Care

Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020

From Critical Care Medicine. The authors measured temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and assessed whether temporal variation in mortality was explained by change...

Physiologic Response to Angiotensin II Treatment for Coronavirus Disease 2019–Induced Vasodilatory Shock: A Retrospective Matched Cohort Study

From Critical Care Explorations. In this study, the authors found that angiotensin-II treatment for coronavirus disease 2019–induced distributive shock was associated with rapid improvement in multiple physiologic indices and that angiotensin-II in coronavirus disease 2019–ind...

   Estimated Time: 25:46 min Coronavirus, COVID-19, Shock, Therapies