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Marilyn N. Bulloch, PharmD, BCPS, FCCM, and Daleen Penoyer, PhD, RN, CCRP, FCNS, FAAN, FCCM, discuss how to develop and operationalize performance improvement teams to implement the Surviving Sepsis Campaign’s (SSC) Hour-1 Bundle, which was developed in 2021 to minimize time to treatment for patients with sepsis and septic shock. This podcast is funded by the Gordon and Betty Moore Foundation through a grant program administered by the Council of Medical Specialty Societies. 0.25 hours of accredited continuing education credit is available for this podcast through May 31, 2024. Visit sccm.org/store for details.
Maureen Madden, DNP, RN, CPNP-AC, CCRN, FCCM, is joined by Mary Jo C. Grant, ACNP, PhD, FAAN, to discuss how to reduce diagnostic delays and errors, with an emphasis on sepsis. This podcast is funded by the Gordon and Betty Moore Foundation through a grant program administered by the Council of Medical Specialty Societies. 0.5 hours of accredited continuing education credit is available for this podcast through March 31, 2024. Visit sccm.org/store for details.
In funding a five-year prospective multicenter study to determine the safest and most effective approach to sepsis intervention, the National Heart, Lung, and Blood Institute (NHLBI) is recognizing the significant accomplishments of the Surviving Sepsis Campaign (SSC) and the Society of Critical Care Medicine (SCCM) to improve outcomes in patients with sepsis.
Using education and technology for accurate and rapid-cycle sepsis diagnoses
Derek Angus, MD, MPH, discusses a new, multicenter research consortium, called Protocolized Care for Early Septic Shock (ProCESS).
Margaret Parker, MD, FCCM, discusses her article published in the January 2009 issue of Critical Care Medicine, titled “An International Survey: Public Awareness and Perception of Sepsis.”
Leticia Castillo, MD, FCCM, discusses an article published in Pediatric Critical Care Medicine, “Secondary HLH and Severe Sepsis/Systemic Inflammatory Response Syndrome/Multiorgan Dysfunction Syndrome/Macrophage Activation Syndrome Share Common Intermediate Phenotypes on a Spectrum of Inflammation.”
Jerry J. Zimmerman, MD, PhD, FCCM, discusses his article published in the January Pediatric Critical Care Medicine, titled “Adjunctive Corticosteroid Therapy in Pediatric Severe Sepsis: Observations From the RESOLVE.”
Marin H. Kollef, MD,discusses an article published in the March 2011 Critical Care Medicine titled, “Implementation of a Real-Time Computerized Sepsis Alerts In Nonintensive Care Unit Patients.”
Craig Coopersmith, MD, FCCM, shares how early involvement within the Society, his receiving the Vision Grant, and his participation in Specialty Sections helped shape his career, while stressing the importance of mentorship.
SCCM president-elect Clifford S. Deutschman, MD, FCCM, professor of anesthesiology and critical care at the University of Pennsylvania School of Medicine in Philadelphia, shares how his involvement within SCCM helped shape aspects of his career.
Margaret Parker, MD, FCCM, associate podcast editor, speaks with Denise M. Goodman, MD, MS, about her article published in the July Pediatric Critical Care Medicine, “Defining Pediatric Sepsis by Different Criteria: Discrepancies in Populations and Implications for Clinical Practice.”
Jeffrey Guy, MD, delves into the conclusions of this article, “Longitudinal changes in procalcitonin in a heterogeneous group of critically ill patients,” with specific focus on why PCT is important when managing patients with suspected sepsis.
Jeffrey Guy, MD, MSc, MMHC, speaks with Christa A. Schorr, RN, MSN, FCCM, about implementing the Surviving Sepsis Campaign (SSC) guidelines.
Michael Weinstein, MD, FACS, FCCP, speaks with David F. Gaieski, MD, lead author on an article published in the May Critical Care Medicine titled, “Benchmarking the Incidence and Mortality of Severe Sepsis in the United States.”
Jeffrey Guy, MD, MSc, MMHC, speaks with R. Phillip Dellinger, MD, MCCM, co-chair of the updated Surviving Sepsis Campaign Guidelines.
Michael Weinstein, MD, FACS, FCCP, speaks with Mitchell P. Fink, MD, FCCM, who is the recipient of the Society of Critical Care Medicine’s Lifetime Achievement Award; he discusses his background in critical care as well as his research endeavors in sepsis in addition to the future of this disease.
Margaret Parker, MD, MCCM, speaks with James L. Wynn, MD, about the article, “Time for a Neonatal-Specific Consensus Definition for Sepsis,” published in Pediatric Critical Care Medicine.
Margaret Parker, MD, MCCM, speaks with Mirjana Cvetkovic, FRCA, about the article, “Timing of Death in Children Referred for Intensive Care with Severe Sepsis: Implications for Interventional Studies,” published in the June 2015 issue of Pediatric Critical Care Medicine.
The Society of Critical Care Medicine’s Immediate Past-President, Craig Coopersmith, MD, FACS, FCCM, discusses the new sepsis definitions published in JAMA and unveiled during the 45th Critical Care Congress.
Margaret Parker, MD, MCCM, speaks with Clifford S. Deutschman, MD, FCCM, about his talk, “Sepsis Redefined: Why Do We Need a New Definition?” presented at the 2016 Critical Care Congress in Orlando, Florida.
Ludwig Lin, MD, speaks with Jane Taylor, Ed.D, about quality improvement science and her contributions to the Surviving Sepsis Campaign.
Ludwig Lin, MD, speaks with Mitchell M. Levy, MD, MCCM, about the release of the “Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016,” presented at the 46th Critical Care Congress in Honolulu, Hawaii.
Todd Fraser, MD, speaks with Christopher W. Seymour, MD, MSc, about the article, “Delays From First Medical Contact to Antibiotic Administration for Sepsis,” published in Critical Care Medicine.
Margaret Parker, MD, MCCM, speaks with Scott L. Weiss, MD, MSCE, about the article, “The Epidemiology of Hospital Death Following Pediatric Severe Sepsis: When, Why, and How Children With Sepsis Die,” published in the September 2017 issue of Pediatric Critical Care Medicine.
Margaret Parker, MD, MCCM, speaks with Stefanie G. Ames, MD, about the article “Hospital Variation in Risk-Adjusted Pediatric Sepsis Mortality,” published in the May 2018 issue of Pediatric Critical Care Medicine.
Ludwig H. Lin, MD, and Philipp Schuetz, MD, discuss procalcitonin and how it impacts treatment of sepsis. This podcast originated from the article "Efficacy and Safety of Procalcitonin Guidance in Patients With Suspected or Confirmed Sepsis: A Systematic Review and Meta-Analysis" (Iankova I, et al. Crit Care Med. 2018;46:691-698).
Margaret M. Parker, MD, MCCM, and Mitchell M. Levy, MD, MCCM discuss the Hour-1 Bundle, the controversies of the Surviving Sepsis Campaign, and the future of sepsis.
Margaret M. Parker, MD, MCCM, and Scott L. Weiss, MD, FCCM, discuss the release of "Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children," published in the February 2020 issue of Pediatric Critical Care Medicine (Weiss S, et al. Pediatr Crit Care Med. 2020;21(2);e52-e106).
Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection. Explore the definition of sepsis and overlap with case descriptions of patients with severe COVID-19, treatment, and more.
Learn about the importance of utilizing dynamic assessments of fluid responsiveness to guide treatment in patients with viral sepsis, including COVID-19, and understand how they can be used to help improve patient outcomes in sepsis patients. Host Pamela M. Peeke, MD, MPH, FACP, FACSM, is joined by Patrick Troy, MD, to discuss how only 50% of hemodynamically unstable patients are fluid responsive and that the same treatment paradigm in fluid management applies to both viral sepsis and COVID-19 patients.
This article describes the new Leapfrog quality metrics and their methodology, focusing on postoperative sepsis identification and the potential impact of dashboard performance tracking moving forward. Critical care professionals routinely encounter patients with sepsis and play an integral role in the formulation and implementation of management plans for postoperative sepsis, making them key participants in this effort.
Since the publication of the Surviving Sepsis Campaign guidelines, the focus has been on sepsis management, early identification, and treatment.
From Critical Care Explorations In this paper, the authors aimed to characterize the kinetics of serum albumin in critically ill patients with coronavirus disease 2019 compared with critically ill patients with sepsis-induced acute respiratory distress syndrome.
From Critical Care Explorations This hypothesis-generating study suggests that the pathophysiology of immunothrombosis differs between coronavirus disease 2019 patients and noncoronavirus disease septic patients.
From Critical Care Explorations In this descriptive statistical study, heart rate variability measures were found to be statistically different across critically ill patients infected with severe acute respiratory syndrome coronavirus 2 and distinct from bacterial sepsis.
Updated global adult sepsis guidelines, released by the Surviving Sepsis Campaign (SSC), place an increased emphasis on improving the care of sepsis patients after they are discharged from the intensive care unit (ICU) and represent greater geographic and gender diversity than previous versions. The updated guidelines are especially important today, as many who are seriously ill with COVID-19 are particularly vulnerable to sepsis.
Critical Care Medicine: October 4, 2021
From Critical Care Medicine. This Editorial accompanies the article “Coronavirus Disease 2019 as a Cause of Viral Sepsis: A Systematic Review and Meta-Analysis” by Karakike et al.
From Critical Care Medicine. The authors report that that majority of coronavirus disease 2019 patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction.
From Critical Care Medicine. This Editorial was written in response to the article by de Roquetaillade et al. entitled “Comparison of Circulating Immune Cells Profiles and Kinetic Between Coronavirus Disease 2019 and Bacterial Sepsis,” which explores the relationship between the immune profile of COVID-19 patients and clinical outcomes.
From Critical Care Medicine. In this article the authors present a longitudinal analysis of the immune response in coronavirus disease 2019 patients, its correlation with outcome, and comparison between severe coronavirus disease 2019 patients and septic patients. They conclude that severe coronavirus disease 2019 is associated with a unique immune profile as compared with sepsis. Several immune features are associated with outcome and suggest that immune monitoring of coronavirus disease 2019 might be helpful for patient management.
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on April 14th, 2021
From Critical Care Medicine. The authors sought to establish the core outcome measures for respiratory failure, multiple organ failure, shortness of breath, recovery, and mortality for trials in coronavirus disease 2019.
This Concise Critical Appraisal delves into a study published in Pediatric Critical Care Medicine that sought to determine whether early hemostatic intervention can prevent the development of DIC and improve outcomes.
From Critical Care Medicine The authors found that procalcitonin exerts a moderate but harmful effect on disease progression in experimental septic shock, and suggests a potential therapeutic application for calcitonin gene-related peptide receptor inhibitors in sepsis.
From Critical Care Medicine The authors tested and found that a previously defined bacterial sepsis endotype classifier recapitulates the same clinical and immunological endotypes in viral sepsis (coronavirus disease 2019).
From Critical Care Medicine The authors invesitated the safety and efficacy of megadose sodium ascorbate in sepsis.
Crit Care Med 2021 Jan;49:e219-e234
Sepsis continues to affect Americans and hospital patients across the United States. The Centers for Disease Control and Prevention (CDC) estimates that approximately 1.7 million adult Americans develop sepsis each year1; this is more than the entire population of Phoenix, the fifth-largest city in the country.2 Approximately 270,000 of these patients die from sepsis.
Children being treated for sepsis stayed in the hospital longer if they lived in low-income ZIP codes compared to those who were from high-income ZIP codes, suggests a large national study being presented at the Society of Critical Care Medicine’s 50th Critical Care Congress.
Severe COVID-19 infection can be a form of viral sepsis with occasionally concomitant bacterial infection.
From Critical Care Medicine. The authors present some common features shared by severe coronavirus disease 2019 patients and sepsis and describe proposed anti-inflammatory therapies for coronavirus disease 2019 which have been previously evaluated in sepsis.
From Critical Care Medicine. In this foreword, the authors contend that there should be no debate that SARS-CoV-2 is an important cause of sepsis and that labeling it as such is beneficial and appropriate.
From Pediatric Critical Care Medicine. In this editorial, the author reviews ""Perspectives on Pediatric Sepsis in Patients with COVID-19"" from the Surviving Sepsis Campaign Pediatric Guidelines Taskforce authors.
From Pediatric Critical Care Medicine. In this editorial, the author discusses issues emerging from the study by Bhumbra et al. (Clinical features of critical coronavirus disease 2019 in children) that are worthy of discussion and further exploration, including the predilection for racial minorities, similarities and differences to sepsis, wide expression of clinical disease, and the conundrum of providing family centered care.
From Pediatric Critical Care Medicine. In this article, the authors discuss the Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-associated Organ Dysfunction in Children as they relate to COVID-19.
Can the biomarkers identified in the Pediatric Sepsis Biomarker Risk Model (PERSEVERE II) be used to predict acute kidney injury and renal recovery in pediatric septic shock? This Concise Critical Appraisal explores a study in which Stanski et al (Am J Respir Crit Care Med. 2020;201:848-855) sought to answer this question.
From Critical Care Explorations. Supportive treatment and immunomodulators have a critical place in the treatment of severe patients until effective antivirals are developed. Interleukin-6 antagonists, one of the immunomodulating agents, appears to be effective in the treatment of cytokine storm, but some patients continue to have severe lymphopenia and immunosuppression.
Most people know Angelica Hale as the tenacious young lady who won hearts with her incredible performances on America’s Got Talent in 2017. But before she became the youngest runner-up in the show’s history, she was a severely ill four-year-old with sepsis and kidney failure. Read ICU Heroes Award winner Angelica Hale's story.
In 2001 a sepsis definitions conference was held to determine whether new data existed to inform updates to the sepsis criteria established in 1991. Afterward, the Society of Critical Care Medicine (SCCM) and the European Society of Intensive Care Medicine (ESICM) announced plans to launch the Surviving Sepsis Campaign (SSC) with the goal of reducing mortality from sepsis by 25%. Given the prominence of sepsis and septic shock as emergency conditions, it is worthwhile to review how care has evolved to its current format and the future directions it may take.
The Society of Critical Care Medicine (SCCM) is committed to reducing mortality and morbidity from sepsis and septic shock worldwide. The Surviving Sepsis Campaign (SSC) released its first evidence-based guidelines for the pediatric patient population. “Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children” was published in the February 2020 issue of Pediatric Critical Care Medicine (Weiss S, et al. Pediatr Crit Care Med. 2020;21(2);e52-e106).
This Concise Critical Appraisal discusses how Carcillo et al (Pediatr Crit Care Med. 2019. Epub ahead of print) compared mortality in children with severe sepsis and MOF who present with one of four phenotypes: 1) immunoparalysis-associated MOF (IPMOF), 2) thrombocytopenia-associated MOF (TAMOF), 3) sequential liver failure-associated MOF (SMOF), and 4) MOF without any immunologic phenotype. The study investigated the association between these phenotypes and macrophage activation syndrome, a potential common pathway of uncontrolled inflammation (Carcillo et al. Pediatr Crit Care Med. 2017;18:S32-S45).
The National Institute of General Medical Sciences (NIGMS) is changing its priorities to invest in sepsis research in a more targeted and strategic way. In an important opportunity to help shape the future of sepsis research, NIGMS has issued a request for information related to its new priorities. The request for information is found here and is due by November 15, 2019.
Killien et al (Pediatr Crit Care Med. 2019;Epub ahead of print) set out to evaluate the prevalence of health-related quality of life (HRQL) decline in pediatric survivors of community-acquired sepsis, severe sepsis, and septic shock and to determine which factors are associated with a failure to return to baseline HRQL.
The Sepsis Alliance aims to educate the public and healthcare professionals about sepsis.
Sepsis is the body’s overwhelming and life-threatening response to infection. This video offers strategies for sepsis survivors and their families