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Maureen A. Madden, DNP, RN, CPNP-AC, CCRN, FCCM, is joined by Katherine Steffen, MD, MHS, to discuss the clinical and economic impacts of compliance with RBC transfusion guidelines, as discussed in “The Impact of Restrictive Transfusion Practices on Hemodynamically Stable Critically Ill Children Without Heart Disease: A Secondary Analysis of the Age of Blood in Children in the PICU Trial” published in Pediatric Critical Care Medicine.