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From Critical Care Explorations. In this study, the authors hypothesized that pro-B-type natriuretic peptide level would be associated with mortality and clinical outcomes in hospitalized coronavirus disease 2019 patients.
From Critical Care Explorations. In this study, the authors found that low-dose methylprednisolone was associated with reduced mortality if given greater than 7 days from onset of symptoms, and no additional benefit greater than 14 days; high dose was associated with higher mortality.
From Critical Care Medicine. In this study, the authors reported that most patients with coronavirus disease 2019 transferred to two Chicago-area long-term acute care hospitals successfully weaned from prolonged mechanical ventilation.
From Critical Care Medicine. In this study, the authors found that in hospital units with moderate or high levels of coronavirus disease 2019 critically ill patients, noncoronavirus disease deaths were at higher levels.
From Critical Care Medicine. The authors concluded that, the obesity paradox, which is the inverse J-shaped association between BMI and mortality in critically ill patients, is not present in critically ill patients with COVID-19–related respiratory failure in contrast to non-SARS-CoV-2 viral and bacterial respiratory infections. Nevertheless, once admitted to the ICU, obese COVID-19 patients also do not have a higher risk for mortality than patients with normal weight.
From Critical Care Medicine. In an international registry of ICU patients with coronavirus disease 2019, stroke was infrequent. Hemorrhagic stroke, but not ischemic stroke, was associated with increased mortality. Further, both hemorrhagic stroke and ischemic stroke were associated with traditional vascular risk factors. Extracorporeal membrane oxygenation use was strongly associated with both stroke and death.
From Critical Care Medicine. The authors sought to determine the association between time period of hospitalization and hospital mortality among critically ill adults with coronavirus disease 2019.
From Critical Care Medicine. This Editorial accompanies the article “Long-Term Acute Care Hospital Outcomes of Mechanically Ventilated Patients With Coronavirus Disease 2019’ by Saad et al.
From Critical Care Medicine. This Editorial accompanies the article “Coronavirus Disease 2019 as a Cause of Viral Sepsis: A Systematic Review and Meta-Analysis” by Karakike et al.
From Critical Care Medicine. The authors report that that majority of coronavirus disease 2019 patients hospitalized in the ICU meet Sepsis-3 criteria and present infection-associated organ dysfunction.
From Critical Care Medicine. The authors sought to determine whether the previously described trend of improving mortality in people with coronavirus disease 2019 in critical care during the first wave was maintained, plateaued, or reversed during the second wave in United Kingdom, when B117 became the dominant strain.
From Critical Care Explorations. This report demonstrates that in a selected group of patients, an “awake” venovenous extracorporeal membrane oxygenation approach is feasible and may result in favorable outcomes.
From Critical Care Explorations. The authors found that this proof-of-principle study demonstrates the feasibility and importance of empirical testing of crisis standards of care guidelines to understand whether they meet their goals.
Update on research and evidence in multisystem inflammatory syndrome in children. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Cardiovascular Complications: Venous Thromboembolism, Myocarditis, and Shock
Controversies in VTE Prophylaxsis; Xa Monitoring for VTE Prophylaxis. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Cardiovascular Complications: Venous Thromboembolism, Myocarditis, and Shock
Viral Shedding and complications with data interpretations; Case presentation from Concord Hospital - Laconia. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Infectious Complications & Management of COVID-19 Infection / Nosocomial
Infection Control and healthcare-associated infections (HAIs) during COVID-19. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Infectious Complications & Management of COVID-19 Infection / Nosocomial
Antiviral and Immunomodulatory Therapies for COVID-19. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Infectious Complications & Management of COVID-19 Infection / Nosocomial
Focus on ABC elements of the ICU Liberation Bundle, specifically, 1) depth of sedation, 2) choosing the right agent, 3) daily interruption of sedation. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: ICU Liberation Bundle Implementation & Challenges
Overview of the Next 5 Choosing Wisely Statements and how they intersect with the ICU Liberation Bundle. And, overview of the "E" element of the ICU Liberation Bundle. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: ICU Liberation Bundle Implementation & Challenges
COVID considerations re: the "F" Element of the ICU Liberation Bundle. Cleveland Clinic example of Family Involvement & Engagement. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: ICU Liberation Bundle Implementation & Challenges
ICU Liberation Bundle Zooming in on the "D" Delirium Component during COVID-19: Problem and Scope, Assessment featuring Management and Post-Intensive Care Syndrome: PICS. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: ICU Liberation Bundle Implementation & Challenges
Quality Improvement Concepts and Practice/Implementation Science This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Quality Improvement Learning Community Session
Noninvasive Management of Respiratory Failure during COVID-19: Case Presentation & Nutrition Support for the COVID19 Patient = NIV/HFNC. This is SCCM curated COVID-19 microlearning content. Curriculum Topic: Approach to Respiratory Failure in the COVID-19 Patient
This resource details monoclonal antibody treatments that can be used to treat COVID-19. This is SCCM curated COVID-19 microlearning content.
From Critical Care Explorations. Interleukin-7 Reverses Lymphopenia and Improves T-Cell Function in Coronavirus Disease 2019 Patient With Inborn Error of Toll-Like Receptor 3: A Case ReportG966
From Critical Care Explorations. The authors sought to evaluate the impact of pharmacologic approach to coronavirus disease 2019 within the ICU on secondary infections and clinical outcomes.
From Critical Care Explorations. In this study, the authors sought to validate prognostic scores in coronavirus disease 2019 including National Early Warning Score, Modified Early Warning Score, and age-based modifications, and define their performance characteristics.
From Critical Care Explorations. In this study, the authors found prolonged reduced exercise capacity up to 6 months in critically ill coronavirus disease 2019 survivors. This disability did not result from residual pulmonary or cardiac dysfunction but rather from a metabolic disorder characterized by a sustained hypermetabolism and an impaired oxygen utilization.
From Critical Care Medicine In this article, the authors assessed whether right ventricular dilation or systolic impairment is associated with mortality and/or disease severity in invasively ventilated patients with coronavirus disease 2019 acute respiratory distress syndrome.
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on June 9th, 2021
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on June 9th, 2021.
From Critical Care Explorations. In this study, the authors hypothesized that elevated soluble suppression of tumorigenicity-2 concentrations, a marker of pulmonary epithelial injury, reflects ongoing lung injury in acute hypoxemic respiratory failure due to coronavirus disease 2019 and associate with continued ventilator dependence.
From Critical Care Explorations. In this Letter to the Editor, the authors report that 17 of 119 coronavirus disease 2019 patients (14%) with ventilator-associated pneumonia developed a lung abscess.
From Critical Care Medicine. In this Online Letter to the Editor, the author responds to the article by Higgins et al. entitled “Coronavirus Disease 2019 ICU Patients Have Higher-Than-Expected Acute Physiology and Chronic Health Evaluation-Adjusted Mortality and Length of Stay Than Viral Pneumonia ICU Patients.”
From Critical Care Medicine. In this Invited Foreword, the authors describe the origins, development, and proof-of-concept testing of the National Emergency Tele-Critical Care Network (NETCCN), a system intended to deliver expertise anywhere needed, at a moment’s notice.
From Critical Care Medicine. This Editorial accompanies an article by Angel et al. entitled “Tracheostomy for Coronavirus Disease 2019 Patients Requiring Mechanical Ventilation.”
From Critical Care Medicine. This Editorial accompanies the article by Mathews et al. entitled “STOP-COVID Investigators. Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019–Related Respiratory Failure.”
From Critical Care Explorations. In this observational study, the authors found that iwithin 48 hours of triage, as well as at any time point in the hospital course, was associated with increased mortality in coronavirus disease 2019 patients.
From Critical Care Explorations. In this observational study, the authors found that prone positioning improves oxygenation across the acute positive respiratory distress syndrome severity spectrum, irrespective of supine respiratory system compliance, end-expiratory pressure, or body mass index. There was a greater relative benefit among patients with more severe disease. Prone positioning confers an additive benefit in oxygenation among patients treated with inhaled nitric oxide.
From Critical Care Medicine. In this study, the authors found that the he institution of nonpharmaceutical interventions was associated with a significant decrease in elective and acute ICU admissions and ICU resource use. These findings may help hospitals and health authorities planning for surge capacities and elective surgery management in future pandemics.
From Critical Care Medicine. In Massachusetts, triage guidelines were designed based on acute illness and chronic life-limiting conditions. In this study, the authors sought to retrospectively validate this protocol to cohorts of critically ill patients from their hospital.
From Critical Care Explorations. In this article, the authors note that the Ventilator Allocation Score can accurately identify patients with high rates of short-term mortality. However, these high mortality patients only represent 27% of all the patients who died, limiting the utility of the score for allocation of scarce resources. The score may unfairly prioritize older patients and inadvertently exacerbate racial health disparities through the inclusion of specific comorbidities such as end stage renal disease. Triage frameworks that include age should be considered. Purposeful efforts, the authors say, must be taken to ensure that triage protocols do not perpetuate or exacerbate prevailing inequities.
This resource details an the usage of renal replacement therapy for COVID-19 patients. This is SCCM curated COVID-19 microlearning content.
This resource details an the usage of extracorporeal blood purification for COVID-19. This is SCCM curated COVID-19 microlearning content.
This resource details an the usage of awake proning with high flow nasal cannula in COVID ARDS. This is SCCM curated COVID-19 microlearning content.
From Critical Care Explorations. Prevalence of superinfections in coronavirus disease 2019 patients requiring mechanical ventilation was high in this series, and bacterial superinfections were independently associated with ICU or 28-day mortality (whichever comes first).
From Critical Care Explorations. In this observational study, the authors found that early CNS symptoms, and pecifically encephalopathy, are differentially associated with risk of severe coronavirus disease 2019 and may serve as an early marker for differences in clinical disease course.
From Critical Care Explorations. Drawing on expertise in critical care medicine, bioethics, and political science, the authors propose a decision-making protocol to ensure fairness in the resolution of conflict, timely decision-making, and accountability to improve system response.
From Critical Care Medicine. In this article, the authors found that endothelial dysfunction is associated with severe acute respiratory syndrome coronavirus 2–related multisystem inflammatory syndrome in children with shock and may constitute one of the underlying mechanisms.
From Critical Care Medicine. In this Online Brief Report, the authors describe rates of return to work versus unemployment following coronavirus disease 2019 acute respiratory distress syndrome requiring intensive care admission.
From Critical Care Explorations. This is a case report on the use of awake extracorporeal membrane oxygenation as a “treatment” for barotrauma due to severe acute respiratory distress syndrome in a coronavirus disease 2019 patient, without the need for invasive mechanical ventilation.
From Critical Care Explorations. In this predictive modeling report, the authors sought to evaluate factors predictive of clinical progression among coronavirus disease 2019 patients following admission, and whether continuous, automated assessments of patient status may contribute to optimal monitoring and management.
From Critical Care Medicine. This Online Letter to the Editor was written in response to an article by Mirsadraee et al. entitled “Prevalence of Thrombotic Complications in ICUTreated Patients With Coronavirus Disease 2019 Detected With Systematic CT Scanning.”
From Critical Care Medicine. This Online Letter to the Editor was written in response to an article by Wongtangman et al. entitled “Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Acute Respiratory Distress Syndrome: A Retrospective Cohort Study.”
From Critical Care Medicine. This Online Letter to the Editor is in response to an article by Doyle et al. entitled “A comparison of thrombosis and hemorrhage rates in patients with severe respiratory failure due to coronavirus disease 2019 and influenza requiring extracorporeal membrane oxygenation.”
From Critical Care Medicine. This Online Letter to the Editor was written in response to an article by Santoro et al. entitled “Anticoagulation Therapy in Patients With Coronavirus Disease 2019: Results From a Multicenter International Prospective Registry (Health Outcome Predictive Evaluation for Corona Virus Disease 2019 [HOPE-COVID19]).”
From Critical Care Medicine. This Editorial accompanies an article by Vassiliou et al. entitled “Increased Glucocorticoid Receptor Alpha Expression and Signaling in Critically Ill Coronavirus Disease 2019 Patients.”
From Critical Care Medicine. This editorial accompanies an article by Carenzo et al. entitled “Return to Work After Coronavirus Disease 2019 Acute Respiratory Distress Syndrome and Intensive Care Admission: Propsective, Case-Series at 6 Months From Hospital Discharge” and calls for future studies to identify evidence for best practice during treatment of acute phase of infection to mitigate some of the long lasting effects as well as factors to help maximize rehabilitation efforts to help survivors to return to their everyday lives.
From Critical Care Medicine. This Editorial was written in response to the article by Chotalia et al. “Right Ventricular Dysfunction and Its Association With Mortality in Coronavirus Disease 2019 Acute Respiratory Distress Syndrome.”
From Critical Care Medicine. This Editorial was written in response to the article by de Roquetaillade et al. entitled “Comparison of Circulating Immune Cells Profiles and Kinetic Between Coronavirus Disease 2019 and Bacterial Sepsis,” which explores the relationship between the immune profile of COVID-19 patients and clinical outcomes.
From Pediatric Critical Care Medicine. In this Special Article, the authors make a call for the field of pediatric critical care to “move forward.” They note that, over a short period, some of the best science and resources have been applied to children with COVID-19 or MIS-C, and that now clinicians and scientists have a different objective: to translate what they learn and know into the highest level of care for patients.
From Critical Care Medicine. In this study, the authors found that ICU coronavirus disease 2019 patients showed upregulated glucocorticoid receptor alpha and glucocorticoid-inducible leucine zipper expression, along with cortisol levels, compared with ICU noncoronavirus disease 2019 patients. Thus, they concluded, on ICU admission, critical coronavirus disease 2019 appears to be associated with hypercortisolemia, and increased synthesis of glucocorticoid receptor alpha and induced proteins.
From Critical Care Medicine. In this Editorial, the authors discuss the article by Wongtangman et al. entitled “Association of Sedation, Coma, and In-Hospital Mortality in Mechanically Ventilated Patients With Coronavirus Disease 2019–Related Acute Respiratory Distress Syndrome” and suggest that reemploying the use of evidence-based strategies developed over the past 20 years through rigorous controlled trials is one of the best mechanisms by which to help critically ill adults with COVID-19 liberate from the ICU and transition toward recovery and survivorship.
From Critical Care Medicine. In this Editorial, the authors discuss the article by Martillo et al. entitled “Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic.”
From Critical Care Medicine. This Online Letter to the Editor was written in response to a paper by Martillo et al. entitled “Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic,’ in which the authors reported a high-proportion of patients suffering from chronic fatigue 1 month after discharge from hospital for ICU-treated coronavirus disease 2019.
Mandate to vaccinate or nudge if there is no budge? COVID-19 vaccines remain a key weapon in the fight against the deadliest modern-day pandemic the world has seen. In this article, we summarize key facts and ethical considerations for healthcare organizations when considering a COVID-19 vaccine mandate for U.S. healthcare workers (HCW).
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on May 12th, 2021
SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Disaster
SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Cardiovascular
SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Quality and Patient Safety
SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Infectious Diseases Society of America (IDSA) COVID-19 Real-Time Learning Network. These resources are categorized as Disaster
Is COVID-19 just atypical acute respiratory distress syndrome (ARDS)? Multidisciplinary faculty will discuss the research and varying answers to this question in this SCCM webcast. During this webcast faculty covered evidence-based best practices for airway management now that more is known about COVID-19. The Society of Critical Care Medicine and the American Association of Respiratory Care partnered to produce this webinar on COVID-19. Webcast Recorded on Wednesday, May 26, 2021
From Critical Care Medicine. In this Editorial, the authors discuss the article by Martillo et al. entitled “Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic.” The Editorial authors conclude that questions remain about when and how to screen for PICS and whether severe COVID-19 survivors have unique symptoms or trajectories compared with non-COVID-19 critical illness survivors, and they emphasize that the main public health message is clear -- critical illness, in general, and severe COVID-19, specifically, are life changing and the critical care community needs to do all it can to prevent the development of PICS and raise awareness.
From Critical Care Medicine. This Online Letter to the Editor was written in response to a paper by Martillo et al. entitled Postintensive Care Syndrome in Survivors of Critical Illness Related to Coronavirus Disease 2019: Cohort Study From a New York City Critical Care Recovery Clinic,’ in which the authors reported a high-proportion of patients suffering from chronic fatigue 1 month after discharge from hospital for ICU-treated coronavirus disease 2019.
SCCM’s COVID-19 Rapid Resource Center now links to pertinent content from the Centers for Disease Control and Prevention (CDC). These resources are categorized as Hematology
This resource details an the usage of tocilizumab as a treatment for severe COVID-19. This is SCCM curated COVID-19 microlearning content.
From Critical Care Explorations. In this systematic review, the authors attempted to retrieve and report the findings of postmortem studies including the histopathologic data of deceased coronavirus disease 2019 patients and to review the manifestations of coronavirus disease 2019–associated thrombotic pathologies reported in the recent literature. Diffuse alveolar damage was the most predominant feature in the lungs of coronavirus disease 2019 patients who underwent postmortem assessment. Widespread pulmonary microthrombosis and extensive pulmonary angiogenesis, in addition to frequent pulmonary and extrapulmonary microthrombotic and thromboembolic findings in patients with coronavirus disease 2019, appear to be consistent with the disease-specific hypercoagulability.
From Critical Care Medicine. This Letter to the Editor is in response to an editorial by Shappell et al. entitled “Does Severe Acute Respiratory Syndrome Coronavirus 2 Cause Sepsis?”
From Critical Care Medicine. In this article the authors present a longitudinal analysis of the immune response in coronavirus disease 2019 patients, its correlation with outcome, and comparison between severe coronavirus disease 2019 patients and septic patients. They conclude that severe coronavirus disease 2019 is associated with a unique immune profile as compared with sepsis. Several immune features are associated with outcome and suggest that immune monitoring of coronavirus disease 2019 might be helpful for patient management.
From Critical Care Explorations. In this article, the authors note that the main therapeutic changes between the first wave of the coronavirus disease 2019 pandemic and the second wave of the coronavirus disease 2019 pandemic were use of steroids, unrestrictive use of high-flow nasal oxygen for hypoxemic patients, and transfer of patients to other geographic areas in the case of ICU overcrowding. They found that these changes were associated with a decrease in 30-day mortality, ICU admission, and organ support.
From Critical Care Explorations. This study aimed to evaluate the prognostic potential of admission neutrophil-lymphocyte ratio in patients admitted to the medical ICU with coronavirus disease 2019. The authors concluded that the neutrophil-lymphocyte ratio at the time of hospital admission is an independent risk factor for morbidity and mortality. This prognostic indicator may assist clinicians appropriately identify patients at heightened risk for a severe disease course and tailor treatment accordingly.
From Critical Care Explorations. In-hospital cardiac arrest survival among coronavirus disease 2019 patients has been reported to range from 0% to 12% -- significantly lower than reported prepandemic in-hospital cardiac arrest survival rates of approximately 20% to 25% in the United States for non–coronavirus disease 2019 patients. In this multi-center study, the authors report a 22% survival to discharge after in-hospital cardiac arrest in coronavirus disease 2019 patients, a survival rate similar with before the coronavirus disease 2019 pandemic.
From Critical Care Explorations. This Letter to the Editor was written in response to the article by Rizvi and Gallo De Moraes entitled “New Decade, Old Debate: Blocking the Cytokine Pathways in Infection-Induced Cytokine Cascade.”
From Critical Care Explorations The authors sought to determine the variation in outcomes and respiratory mechanics between the subjects who are intubated earlier versus later in their coronavirus disease 2019 course.
From Critical Care Explorations. In this study, the authors reviewed the demographics, characteristics, comorbidities, complications, and outcomes of hospitalized patients with severe acute respiratory syndrome coronavirus 2, and their association with mortality at medical center in Orlando, Florida.
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on April 14th, 2021
This infographic covers pearls on how to mitigate post-COVID-19: from ICU to discharge. This is SCCM curated COVID-19 microlearning content.
This webinar panel discussed ways to mitigate the risk of post-acute sequelae of COVID-19 (PASC) in hospitalized COVID-19 patients. The panelists and attendees participated in an interactive discussion format with case presentations, polling, and given access to a downloadable infographic to use as a resource tool. The Society of Critical Care Medicine and the American Association of Respiratory Care partnered to produce this webinar on COVID-19. Webcast Recorded on Thursday, April 29, 2021
From Pediatric Critical Care Medicine. This study delineates significant clinically relevant differences in presentation, explanatory factors, and outcomes among children admitted to PICU with severe acute respiratory syndrome coronavirus 2–related illness stratified by multisystem inflammatory syndrome in children.
From Critical Care Medicine. The authors found that physical disability is common at 3 months in severe coronavirus disease 2019 survivors. Lung diffusing capacity and intermuscular adipose tissue assessed on CT were independently associated with walking distance, suggesting a key role for pulmonary function and muscle quality in functional disability.
From Critical Care Medicine. In this systematic review and meta-analysis, the authors found that, despite the significant variability in frequency and duration of prone positioning and respiratory supports applied, prone positioning was associated with improvement in oxygenation variables without any reported serious adverse events.
From Critical Care Explorations. In this Letter to the Editor, the authors respond to an article by Dupuis et al., congratulating the contribution to the problem of identifying which patients with hypoxemic respiratory failure truly benefit from invasive ventilation and suggesting future studies of invasive ventilation consider using the target trial concept in order to minimize bias and maximize the clinical applicability of results.
From Critical Care Explorations. In this single-center study, the authors found that the majority of deaths in severe acute respiratory syndrome coronavirus 2–positive hospitalized patients were related to a typical or atypical presentation of coronavirus disease 2019 disease.
From Critical Care Explorations. In this commentary, the authors note that low-quality care has become a greater determinant of mortality than lack of access. To address this, they suggest a systems-wide approach to improving the quality of mechanical ventilation in resource-limited settings, which includes consideration of the interdependent ventilator design constraints such as cost and complexity, hospital infrastructure, availability of medications, and trained personnel.
From Critical Care Explorations. The authors sought to determine how several existing crisis standards of care triage protocols would have distinguished between patients with coronavirus disease 2019 requiring intensive care.
This infographic details health care worker burnout. This is SCCM curated COVID-19 microlearning content.
This resource is an infographic detailing pressure injuries. This is SCCM curated COVID-19 microlearning content.
This resource details Post-Acute COVID-19 Syndrome (PASC). This is SCCM curated COVID-19 microlearning content.
From Critical Care Medicine. In this Editorial, the wonder if the use of convalescent plasma needs to be further whittled to an even smaller subset of patients and ultimately whether there is even a practical role for this therapy in the treatment of COVID-19 particularly in hospitalized patients.
From Critical Care Medicine. In this Online Letter to the Editor, the authors write in response to an article by Frontera et al. in Critical Care Medicine about etiology of hyponatremia in coronavirus disease 2019 (COVID-19) patients.
From Critical Care Medicine. In this review article, the authors compared the rates of cardiac injury by angiotensin converting enzyme-2–binding viruses from viruses that do not bind to angiotensin-converting enzyme-2.
From Critical Care Medicine. In this study, the authors found that administration of convalescent plasma to hospitalized patients with coronavirus disease 2019 infection increased antibodies to severe acute respiratory syndrome coronavirus disease 2 but was not associated with improved outcome.
From Critical Care Medicine. This letter to the editor was written in response to "Early Percutaneous Tracheostomy in Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients."
From Critical Care Medicine. The authors compared APACHE-IV–adjusted mortality and length of stay outcomes of adult ICU patients who tested positive for coronavirus disease 2019 with patients admitted to ICU with other viral pneumonias.
From Critical Care Medicine. The authors investigate if a restrictive visitor policy inadvertently lengthened the decision making process for dying inpatients without coronavirus disease 2019.
From Critical Care Medicine. In this editorials, the authors discuss hospital preparedness in the article "Variation in Initial U.S. Hospital Responses to the Coronavirus Disease 2019 Pandemic."
From Critical Care Medicine. The authors tested the hypothesis that patients with coronavirus disease 2019–associated acute respiratory distress syndrome are at higher risk of in-hospital mortality due to prolonged coma compared with other patients with acute respiratory distress syndrome matched for disease severity.
From Critical Care Medicine. The authors evaluate the impact of ICU surge on mortality and to explore clinical and sociodemographic predictors of mortality.
This resource details an update on MIS-C during the COVID-19 pandemic. This is SCCM curated COVID-19 microlearning content.
Questions from social media, blogs and the various discussion forums, including the new SCCM COVID-19 Discussion Group, were answered. This microlearning content was taken from the COVID-19 Critical Care for Non-ICU Clinicians: Expert Panel Series held on March 10, 2021
From Critical Care Medicine. The authors characterize emergency responses across hospitals in the United States over time and in the context of local case rates early in the coronavirus disease 2019 pandemic.
From Critical Care Medicine. The authors assess the impact of percutaneous dilational tracheostomy in coronavirus disease 2019 patients requiring mechanical ventilation and the risk for healthcare providers.
From Critical Care Medicine. The authors evaluate the efficacy of anticoagulation in coronavirus disease 2019 hospitalized patients and its impact on survival.
From Critical Care Medicine. The authors describe and compare rates of venous thromboembolism and hemorrhage in patients with coronavirus disease 2019 against a historic population of patients with influenza pneumonia who required extracorporeal membrane oxygenation.
From Critical Care Explorations. In this brief report, the authors conclude there are indications that registered nurses providing care for coronavirus disease 2019 in the ICU reported increased thermal discomfort coinciding with elevated energy expenditure and a more pronounced self-perception of effort, stress, and mental demand.
From Critical Care Explorations. While the collaborative model can help promote ICU family engagement initiatives, the authors found that coronavirus disease 2019 has impeded implementation of these initiatives even among motivated units.
From Critical Care Explorations. The authors evaluated the in vitro effects of dexamethasone phosphate on T cell function in peripheral blood mononuclear cells derived from patients with acute, severe, and moderate coronavirus disease 2019.
From Critical Care Medicine. In this editorial, the authors discuss hospital staff safety in the article "Transmission of Severe Acute Respiratory Syndrome Coronavirus 1 and Severe Acute Respiratory Syndrome Coronavirus 2 During Aerosol-Generating Procedures in Critical Care: A Systematic Review and Meta-Analysis of Observational Studies" by Chan et al.
From Critical Care Medicine. This online letter to the editor was written in response to Early Percutaneous Tracheostomy In Coronavirus Disease 2019: Association With Hospital Mortality and Factors Associated With Removal of Tracheostomy Tube at ICU Discharge. A Cohort Study on 121 Patients" by Rosano et al.
From Critical Care Medicine. This online letter to the editor was written in response to " Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest?" by Shah et al.
From Critical Care Explorations. The authors identify the most efficacious timing for tocilizumab administration in critically ill patients infected with severe acute respiratory syndrome coronavirus-2.
From Critical Care Explorations. The authors describe the nationwide U.K. PICU experience of severe acute respiratory syndrome coronavirus-2 infection during the first wave of the pandemic and compare this with the critical care course of the 2019 influenza cohort.
From Critical Care Explorations. The authors investigated the differences in clinical course, ventilator mechanics, and outcomes of patients with coronavirus disease 2019 secondary to acute respiratory distress syndrome infection compared with a historical cohort of acute respiratory distress syndrome.
From Critical Care Explorations. In this Letter to the Editor, the authors report initial patient characteristics and outcomes from a large quaternary referral center in New York City between Spring, Summer, and Winter, including prevalence of renal failure, respiratory failure, and mortality; stratified across several key populations of interest including all patients, ICU patients, those requiring of noninvasive positive pressure ventilation and high-flow nasal cannula, and those intubated in each time period.
From Pediatric Critical Care Medicine. The authors analyzed the short-term biochemical improvements and clinical outcomes following treatment of children with postsevere acute respiratory syndrome coronavirus-2 inflammatory syndrome (multisystem inflammatory syndrome in children/pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus-2) admitted to U.K. PICUs and collated current treatment guidance from U.K. PICUs.
In the past few weeks more than 7 million doses of Johnson & Johnson’s Janssen COVID-19 vaccine have been administered to people in the United States. In clinical trials of approximately 40,000 people, the J&J vaccine given as a single shot was 66% effective at preventing the illness due to the SARS-CoV-2 virus known as COVID-19. Because the J&J vaccine is a single shot, it has been preferred in some circumstances.
This resource details maternal mortality during the COVID-19 pandemic. This is SCCM curated COVID-19 microlearning content.
This resource details COVID-19 and pregnancy management. This is SCCM curated COVID-19 microlearning content.
This resource details methods for awake self-proning for COVID-19 patients with ARDS. This is SCCM curated COVID-19 microlearning content.
The care of patients with COVID-19 requires careful steps for preventing infection of staff and other patients throughout the continuum care from the emergency department to the ICU. This webinar consisted of an expert panel discussion of questions and case studies that addressed burning questions. Participants also received an infographic with pearls from the panel experts to help in their practice. Webcast Recorded on Friday, March 26, 2021
This infographic resource details best practices to mitigate infection control from the ED to the ICU. This is SCCM curated COVID-19 microlearning content.
From Critical Care Medicine. This online letter to the editor was written in response to “Reversal of the Pathophysiological Responses to Gram-Negative Sepsis by Megadose Vitamin C” by Lankadeva et al
From Critical Care Medicine. This online letter to the editor was written in response to the article “Is Cardiopulmonary Resuscitation Futile in Coronavirus Disease 2019 Patients Experiencing In-Hospital Cardiac Arrest? By Shah et al.
From Critical Care Medicine. In this article, authors found that survivors of critical illness related to coronavirus disease 2019 are at high risk of developing postintensive care syndrome.
From Critical Care Medicine. This is an online Letter to the Editor in response to “De Novo Renal Failure and Clinical Outcomes of Patients With Critical Coronavirus Disease 2019” by Forest et al.
From Critical Care Medicine. This an online Letter to the Editor in response to the article by Sweeney et al. “Validation of Inflammopathic, Adaptive, and Coagulopathic Sepsis Endotypes in Coronavirus disease 2019."
From Critical Care Medicine. This is an online Letter to the Editor in response to the article by Fernandez et al. “Plasma Exchange: An Effective Rescue Therapy in Critically Ill Patients With Coronavirus Disease 2019 Infection.”
From Critical Care Explorations. The authors’ data, discussed in this article, did not support the use of thromboelastography to risk stratify critically ill adults with coronavirus disease 2019 for the development of venous thromboembolism or to guide decisions about anticoagulation.
From Critical Care Medicine. In this study, the authors found that stress, staffing, and, to a lesser degree, personal protective equipment shortages faced by U.S. critical care physicians remain high, with stress levels higher among women.
From Critical Care Medicine. The authors investigated the incidence, characteristics, and outcomes of in-hospital cardiac arrest in patients with coronavirus disease 2019 and describe the characteristics and outcomes for patients with in-hospital cardiac arrest within the ICU, compared with non-ICU patients with in-hospital cardiac arrest.
From Critical Care Explorations. In this review article, the authors summarize the current state of research in coronavirus disease 2019 pathophysiology within the context of potential organ-based disease mechanisms and opportunities for translational research.
From Critical Care Explorations. In this study, the authors share a new approach for rapidly developing a decision-support tool for prioritizing patients with coronavirus 2019 disease for admission to ICUs.
From Critical Care Explorations. The authors examined ICU census trends in relation to ICU bed capacity during the rapid increase in severe coronavirus disease 2019 cases early during the pandemic, and concluded they concluded tha ttheir findings demonstrate the short-term adaptability of U.S. healthcare institutions in redirecting limited resources to accommodate a public health emergency.
From Critical Care Explorations. The authors performed anticoronavirus immunoglobulin G profiling of critically ill coronavirus disease 2019 patients to better define their underlying humoral response.
From Critical Care Explorations. This point prevalence study showed low implementation of the ABCDEF bundle for patients with COVID-19.
From Critical Care Explorations. In this retrospective case series of 29 patients, the authors demonstrated efficacy of extracorporeal Co2 removal using the Hemolung Respiratory Assist System to improve respiratory acidosis in patients with severe hypercapnic respiratory failure due to coronavirus disease 2019.
From Critical Care Explorations. The authors describe implementing a connected network between two tele-ICU programs to support staffing and rounding during the first wave of the coronavirus disease 2019 pandemic in the United States.
From Critical Care Explorations. The authors describe sedative and analgesic drug utilization in a cohort of critically ill patients with coronavirus disease 2019 and compare standard sedation with an alternative approach using inhaled isoflurane.
From Pediatric Critical Care Medicine. In this article, the authors found that hybrid rounds employed during pandemic facilitated social distancing while retaining patient-centered multidisciplinary ICU rounds but compromised teaching during rounds.
From Critical Care Medicine. In this Online Letter to the Editor, the authors comment on an article by Rosano et al. in which it was demonstrated that early tracheostomy can be performed with acceptable safety in the midst of a pandemic and note that the study raises important questions related to the downsides of routinely performing tracheostomy, tailoring timing of tracheostomy and optimal protocols for decannulation.
From Pediatric Critical Care Medicine. The authors of this Editorial sought to assess the evolving discussion surrounding the naming of a novel pediatric hyperinflammatory syndrome – a condition that showed overlapping features of Kawasaki disease and toxic shock syndrome -- through the analysis of its evolution around the Twitter hashtag #PedsICU.