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Discover IHCA Project

Investigate in-hospital cardiac arrests and post-resuscitation care.

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The Discover In-Hospital Cardiac Arrest (IHCA) study is a multicenter, prospective observational study aimed at better understanding variations in practice for the post-cardiac arrest patient. There is considerable debate among experts concerning many components of intra- and post-arrest care. This study aims to increase the evidence base of these components, particularly temperature control and neuroprognistication in post-arrest patients. In addition to providing insights regarding immediate and long-term post-arrest care, data collected will also be useful in studying variation in cardiopulmonary resuscitation practices.

This project is endorsed by the Society of Critical Care Medicine’s (SCCM) Discovery, the Critical Care Research Network.


Frequently Asked Questions


Why focus on IHCA?
​IHCA is a major public health issue, with nearly 300,000 IHCAs occurring each year in the United States. Most available evidence supporting cardiac arrest management is from the study of out-of-hospital cardiac arrest. Guidelines for IHCA management are generally based on these data, without considering the unique circumstances surrounding IHCA.

While morbidity and mortality of IHCA have improved in recent years, survival remains low among those who achieve return of spontaneous circulation, and rates of long-term physical and cognitive recovery remain low. In this study, we aim to increase data available specifically relating to IHCA. 


Can additional hospitals participate? 

Additional hospitals are encouraged to participate. The investigators would like to include a variety of hospitals and patients. Currently, we are particularly interested in adding rural and community hospitals to the study. If your hospital is interested in participating in the study, please contact the principal investigator. 

How will data collection occur? 

Data regarding hospital and patient characteristics, intra-arrest events, and post-arrest practices will be abstracted from medical records by each participating site and entered into a research electronic data capture cloud database (REDCap) hosted by SCCM. 

What is the timeline for the project? 

Data will be collected over a six-month period estimated to begin in the fall of 2023, with initial data analysis occurring shortly thereafter. 


Ari Moskowitz, MD
Principal Investigator
Ari Moskowitz, MD

Assistant Professor, Department of Medicine (Critical Care)
Montefiore Medical Center
Bronx, New York, USA

SCCM Staff Contact: Tamara Al-Hakim

  • George L. Anesi, MD, MSCE, MBE, University of Pennsylvania
  • Pavan Bhatraju, MD, MSc, University of Washington
  • J. Perren Cobb, MD, FCCM, University of Southern California
  • Chris Kratochvil, MD, University of Nebraska
  • Douglas Landsittel, PhD, University of Pittsburgh
  • Richard Lee, MD, University of California, Irvine
  • Janice Lieber, MD, University of Southern California
  • Karen Lutrick, PhD, University of Arizona
  • David Brett-Major, MD, MPH, University of Nebraska
  • Vikramjit Mukherjee, MD, NYU Langone
  • Radu Postelnicu, MD, NYU Langone
  • Leopoldo N. Segal, MD, NYU Langone
  • Jonathan E. Sevransky, MD, FCCM, Emory University
  • Timothy Uyeki, MD, Centers for Disease Control and Prevention
  • Mark M. Wurfel, MD, PhD, University of Washington
  • David Wyles, MD, Denver Health
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SARI-PREP in the News

SARI-PREP in the News

Press releases and news articles highlighting SARI-PREP activities.

Recent Publications

Perceived Hospital Stress, Severe Acute Respiratory Syndrome Coronavirus 2 Activity, and Care Process Temporal Variance During the COVID-19 Pandemic
Anesi GL, Andrews A, Bai H, et al; for the Severe Acute Respiratory Infection-Preparedness (SARI-PREP) Study Group. Perceived hospital stress, severe acute respiratory syndrome coronavirus 2 activity, and care process temporal variance during the COVID-19 pandemic. Crit Care Med. 2023 Feb 15. doi: 10.1097/CCM.0000000000005802. Online ahead of print.

Severe Acute Respiratory Infection—Preparedness: Protocol for a Multicenter Prospective Cohort Study of Viral Respiratory Infections
Postelnicu R, Srivastava A, Bhatraju PK, et al; Society of Critical Care Medicine Discovery Network Investigators. Severe Acute Respiratory Infection—Preparedness: protocol for a multicenter prospective cohort study of viral respiratory infections. Crit Care Explor: 2022 Oct 20;4(10):e0773. doi: 10.1097/CCE.0000000000000773

Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events
Anesi G, Sevransky J, Cobb J, Evans L. Hospital Stress, Adaptation, and Resiliency During Respiratory Viral Acute Surge Events. 2021 Jun.

Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study
Bhatraju PK, Morrell ED, Zelnick L, Sathe NA, Chai XY, Sakr SS, Sahi SK, Sader A, Lum DM, Liu T, Koetje N, Garay A, Barnes E, Lawson J, Cromer G, Bray MK, Pipavath S, Kestenbaum BR, Liles WC, Fink SL, West TE, Evans L, Mikacenic C, Wurfel MM. Comparison of host endothelial, epithelial and inflammatory response in ICU patients with and without COVID-19: a prospective observational cohort study. Crit Care. 2021 Apr 19;25(1):148.

Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome
Sulaiman I, Chung M, Angel L, et al. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258.

Hospital Stress and SARI-PREP

George L. Anesi, MD, MSCE, MBE, discusses how SARI-PREP is gathering qualitative data from study sites to answer questions on how hospital strain has influenced usual operations and staffing.

SARI-PREP and Microbes in COVID-19

Leopoldo Segal, MD, shares how his research lab developed novel ways to investigate what COVID-19 does in the body, especially the lungs.